U24 from Roseolovirus interacts strongly with Nedd4 WW Domains [PDF]
Scientific Reports, 2017 AbstractU24 is a protein found in both roseoloviruses Human Herpes Virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminus that is rich in prolines (PY motif in both HHV-6A and 7; PxxP motif in HHV-6A). Previous work has shown that the interaction between U24 and WW domains is important for endocytic recycling of T-cell receptors, but a cognate ligand
Yurou Sang +5 more
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Potential Infectious Complications in Pig Xenograft Donors and Recipients [PDF]
Transplant InternationalPreclinical and clinical xenotransplantation trials have shown that successful outcomes depend on a number of factors including the prevention of xenozoonoses.
Nicolas J. Mueller, Linda Scobie
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The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights [PDF]
BiomedicinesCardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Martin Bender +23 more
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Comparison of methods for the detection of porcine cytomegalovirus/roseolovirus in relation to biosafety monitoring of xenotransplantation products [PDF]
Xenotransplantation, 2023 AbstractBackgroundThe porcine cytomegalovirus, a porcine roseolovirus (PCMV/PRV), is widely distributed in pig populations. It has been shown that PCMV/PRV was transmitted by pig xenotransplants to non‐human primates, and significantly reduced the survival time of the recipient.
Joachim Denner +3 more
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Past, present, and future perspectives on the diagnosis of Roseolovirus infections [PDF]
Current Opinion in Virology, 2014 Diagnosis of Roseolovirus infections mandates careful selection of patients, samples, and testing methods. We review advances in the field and highlight research priorities. Quantitative (q)PCR can accurately identify and distinguish between human herpesvirus 6 (HHV-6) species A and B.
Joshua A. Hill +2 more
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Murine Roseolovirus, Historically Known as Murine Thymic Lymphotropic Virus [PDF]
Journal of Virology, 2017 Chuanwu Wang +2 more
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Prevalence of the porcine cytomegalovirus virus (PCMV), a porcine roseolovirus, in wild boars in Italy and Germany [PDF]
, 2022 Abstract Porcine cytomegalovirus (PCMV), which is a porcine roseolovirus (PRV), closely related to the human herpesviruses 6 and 7, is common among commercial pigs. PCMV/PRV was shown to be important in xenotransplantation because transmission of PCMV/PRV in preclinical trials transplanting pig organs into non-human primates was associated with
Sabrina Hansen +6 more
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Roseolovirus molecular biology: recent advances [PDF]
Current Opinion in Virology, 2014 Human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, and HHV-7) are classified within the roseolovirus genus of the betaherpesvirus subfamily. Most humans likely harbor at least two of these large DNA viruses, and 1% of humans harbor germline chromosomally integrated (ci) HHV-6A or HHV-6B genomes.
Laurie T. Krug, Philip E. Pellett
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CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection [PDF]
The Journal of Immunology, 2017 Abstract A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4+ cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with ...
Swapneel J. Patel, Wayne M. Yokoyama
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Role of a Porcine Herpesvirus, PCMV/PRV, in Xenotransplantation [PDF]
Transplant InternationalJoachim Denner
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