OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections. [PDF]
XenotransplantationABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Denner J.
europepmc +2 more sources
Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights. [PDF]
J Med VirolABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Guimarães ACS +9 more
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No Evidence for a Major Risk of Roseolovirus Vertical Transmission During Pregnancy [PDF]
Clinical Infectious Diseases, 2003 David Boutolleau +6 more
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Interactions of U24 from Roseolovirus with WW domains: canonical vs noncanonical
Biochemistry and Cell Biology, 2017 U24 is a C-terminal membrane-anchored protein found in both human herpes virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminal segment that is rich in prolines (PPxY motif in both HHV-6A and 7; PxxP motif in HHV-6A). Previous work has shown that U24 interacts strongly with Nedd4 WW domains, in particular, hNedd4L-WW3*.
Yurou Sang +4 more
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Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju [PDF]
Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., 2016 Abstract Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses ...
Svetlana Čapenko +6 more
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Differential Impacts of HHV-6A versus HHV-6B Infection in Differentiated Human Neural Stem Cells
Frontiers in Immunology, 2022 Within the family Herpesviridae, sub-family β-herpesvirinae, and genus Roseolovirus, there are only three human herpesviruses that have been described: HHV-6A, HHV-6B, and HHV-7.
Elham Bahramian +7 more
doaj +1 more source
Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown pathogenic in the context of xenotransplantation. Transmission of PCMV/PRV to non-human primates receiving hearts or kidneys from virus-positive pigs significantly reduced the survival time of the recipients.
Hina Jhelum +3 more
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Protein interactions of membrane protein U24 from Roseolovirus and implications for its function
, 2016 This dissertation describes the investigation of the interactions between the tail-anchored membrane protein U24 from Human Herpesvirus type 6A (HHV-6A) and type 7 (HHV-7) and its potential binding partners. The roles that these interactions play in U24s’ function will be presented.
Yurou Sang
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Genomic Validation of PERV-C-Free Pigs to Support Xenotransplantation. [PDF]
XenotransplantationABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Benjamin NR +6 more
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Roseolovirus role in the development of infectious and inflammatory diseases affecting the upper respiratory tract in children [PDF]
Russian Medical InquiryBackground: roseoloviruses, including human herpesvirus (HHV) 6A/B and HHV-7, are implicated in several diseases but remain underexplored among clinically healthy individuals. Aim: this study aims to assess the role of HHV-6A, HHV-6B, and HHV-7 in the onset of infectious and inflammatory diseases affecting the upper respiratory tract in children ...
P.V. Vlasov +6 more
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