Results 51 to 60 of about 1,435 (139)
Pig-to-human kidney xenotransplants using genetically modified minipigs
Cell Reports MedicineSummary: This study develops an observational model to assess kidney function recovery and xenogeneic immune responses in kidney xenotransplants, focusing on gene editing and immunosuppression.
Yi Wang +28 more
doaj +1 more source
Viruses, 2017 Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry ...
Joshua G. Tweedy +3 more
doaj +1 more source
, 2023 Microbiome-host data integration. Unsupervised Spearman rank correlation was performed between appropriately transformed host gene and microbial genus counts. Significant correlations were defined as those with absolute correlation coefficient (rs) ≥ 0.6
Fadhl Alakwaa (15313640) +9 more
core +1 more source
Humanized Mouse Models of Epstein Barr Virus Infection
Current Protocols, Volume 5, Issue 11, November 2025.Abstract The oncogenic Epstein Barr virus (EBV) is an exclusively human pathogen with related lymphocryptoviruses (γ1‐herpesviruses) only present in monkeys. Therefore, experimentation with EBV infection in a small animal model requires reconstitution or adoptive transfer of human lymphocyte populations, primarily EBV's main host cell, the human B cell.
Saskia Gertrud von Boxberg +5 more
wiley +1 more source
Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders
Frontiers in Microbiology, 2018 Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Bhupesh K. Prusty +11 more
doaj +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley +1 more source
Xenotransplantation, Volume 32, Issue 1, January/February 2025.ABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Joachim Denner +4 more
wiley +1 more source
Working with Miraculous Mice: Mus musculus as a Model Organism
Current Protocols, Volume 4, Issue 10, October 2024.Abstract The laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research.
Anick Standley +4 more
wiley +1 more source
A murine herpesvirus closely related to ubiquitous human herpesviruses causes T-cell depletion
, 2017 The human roseoloviruses human herpesvirus 6A (HHV-6A), HHV-6B, and HHV-7 comprise the Roseolovirus genus of the human Betaherpesvirinae subfamily. Infections with these viruses have been implicated in many
Guoyan Zhao +22 more
core +1 more source