Results 61 to 70 of about 1,505 (144)

Additional file 1 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

, 2022
Additional file 1: Supplementary Fig. 1. Peripheral, neonatal MRV infection in 5XFAD mice does not accelerate Aβ plaque burden. A, Schematic of experimental paradigm (6 mpi). B, C, Percent of CD4+ and CD8+ T cells in plasma 10 dpi (B) or 6 mpi (C). D, E, HJ3.4B+ immunostaining for Aβ plaque load in the cortex. F–I, Staining and quantification for Tau5+
Bigley, Tarin M., Xiong, Monica, Ali, Muhammad, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Eteleeb, Abdallah, Harari, Oscar, Yang, Liping, Patel, Swapneel J., Cruchaga, Carlos, Yokoyama, Wayne M., Holtzman, David M.   +12 more
openaire   +1 more source

Genomic Validation of PERV‐C‐Free Pigs to Support Xenotransplantation

Xenotransplantation, Volume 33, Issue 1, January/February 2026.
ABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Neal R. Benjamin, Giovanni Madrigal, Yasuko Ishida, Julian Catchen, Kari L. Allen, Brent Pepin, Alfred L. Roca   +6 more
wiley   +1 more source

Additional file 3 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

, 2022
Additional file 3: Supplementary Fig. 3. Effects of acute, intrahippocampal MRV infection on tau pathology. A, Schematic of experimental paradigm. B – G, Staining and quantification for Tau5+ total tau (B, C, D) and AT8+ phosphorylated tau in the cortex (E, F, G). p-tau: phosphorylated tau. Scale bar: 500 μm.
Bigley, Tarin M., Xiong, Monica, Ali, Muhammad, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Eteleeb, Abdallah, Harari, Oscar, Yang, Liping, Patel, Swapneel J., Cruchaga, Carlos, Yokoyama, Wayne M., Holtzman, David M.   +12 more
openaire   +1 more source

Humanized Mouse Models of Epstein Barr Virus Infection

Current Protocols, Volume 5, Issue 11, November 2025.
Abstract The oncogenic Epstein Barr virus (EBV) is an exclusively human pathogen with related lymphocryptoviruses (γ1‐herpesviruses) only present in monkeys. Therefore, experimentation with EBV infection in a small animal model requires reconstitution or adoptive transfer of human lymphocyte populations, primarily EBV's main host cell, the human B cell.
Saskia Gertrud von Boxberg, Kristin Gehrmann, Svenja Luisa Nopper, Lucas Romann, Svenja Kösegi, Christian Münz   +5 more
wiley   +1 more source

Roseomics: a blank slate [PDF]

, 2014
Recent technological advances have led to an explosion in the system-wide profiling of biological processes in the study of herpesvirus biology, herein referred to as “-omics”.
Murphy, Eain A, Moorman, Nathaniel J
core   +1 more source

FIGURE 6 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma

, 2023
Microbiome-host data integration. Unsupervised Spearman rank correlation was performed between appropriately transformed host gene and microbial genus counts. Significant correlations were defined as those with absolute correlation coefficient (rs) ≥ 0.6
Fadhl Alakwaa (15313640), Vinay Jain (15313628), Tsute Chen (15313637), Kathy Q. Cai (15313643), Kumaraswamy N. Chitrala (15425913), Nezar N. Al-Hebshi (15425916), Doaa E. El-Hadedy (15425907), Divyashri Baraniya (15313631), Michael Slifker (15425910), Christopher Fundakowski (15313649)   +9 more
core   +1 more source

Additional file 2 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

, 2022
Additional file 2: Supplementary Fig. 2. Comparisons between MRV purified and unpurified stocks. A – C, Stocks were created from in vivo passage and collection of 7 day post neonatal infection thymi and were used directly (MRV Stock) or semi-purified (MRV Purified).
Bigley, Tarin M., Xiong, Monica, Ali, Muhammad, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Eteleeb, Abdallah, Harari, Oscar, Yang, Liping, Patel, Swapneel J., Cruchaga, Carlos, Yokoyama, Wayne M., Holtzman, David M.   +12 more
openaire   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Additional file 1 of Detection of porcine cytomegalovirus, a roseolovirus, in pig ovaries and follicular fluid: implications for somatic cells nuclear transfer, cloning and xenotransplantation

, 2023
Additional file 1: Demonstration of real-time PCR testing of pig oocytes for PCMV/PRV. As positive control a gene block was used.
Hansen, Sabrina, Fischer, Konrad, Krabben, Ludwig, Rinke Carrapeiro, Alexander, Klinger, Bernhard, Schnieke, Angelika, Kaufer, Benedikt, Denner, Joachim   +7 more
openaire   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source