Results 71 to 80 of about 1,950 (144)

Microchimerism, PERV and Xenotransplantation [PDF]

, 2023
Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish ...
Denner, Joachim
core   +1 more source

An Optimized Protocol for the Generation of iPSC Lines from Lymphoblastoid Cell Lines Using the Non‐integrative Sendai Virus

Current Protocols, Volume 6, Issue 3, March 2026.
Abstract The choice of cell source for generating induced pluripotent stem cells (iPSCs) is influenced by several factors, including accessibility, reprogramming efficiency, and the invasiveness of the cell collection procedure. Traditional sources such as skin fibroblasts or peripheral blood mononuclear cells often require invasive sampling, which can
Laurie Martineau, Isabella Bienjonetti, Sabrina Bellenfant, Jack Puymirat, François Gros‐Louis   +4 more
wiley   +1 more source

Pig-to-human kidney xenotransplants using genetically modified minipigs

Cell Reports Medicine
Summary: This study develops an observational model to assess kidney function recovery and xenogeneic immune responses in kidney xenotransplants, focusing on gene editing and immunosuppression.
Yi Wang, Gang Chen, Dengke Pan, Hui Guo, Hongtao Jiang, Jianli Wang, Hao Feng, Songzhe He, Jiaxiang Du, Man Zhang, Tao Li, Yong Wang, Hang Yu, Huiling Gan, Quan Wen, Zhian Song, Desheng Li, Yifan Yu, Huanliang Wang, Bing Li, Yong You, Shen Zhou, Mingfa Wang, Lili Liu, Liang Xu, Meng Yang, Hua Pei, Kang Zhang, Zhonghua K. Chen   +28 more
doaj   +1 more source

Humanized Mouse Models of Epstein Barr Virus Infection

Current Protocols, Volume 5, Issue 11, November 2025.
Abstract The oncogenic Epstein Barr virus (EBV) is an exclusively human pathogen with related lymphocryptoviruses (γ1‐herpesviruses) only present in monkeys. Therefore, experimentation with EBV infection in a small animal model requires reconstitution or adoptive transfer of human lymphocyte populations, primarily EBV's main host cell, the human B cell.
Saskia Gertrud von Boxberg, Kristin Gehrmann, Svenja Luisa Nopper, Lucas Romann, Svenja Kösegi, Christian Münz   +5 more
wiley   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source

Клінічно-епідеміологічні особливості інфекцій, викликаних вірусами герпесу 6-го та 7-го типів (огляд літератури) [PDF]

, 2013
У статті висвітлено сучасні уявлення про герпесвірусні інфекції, спричинені вірусами герпесу людини 6-го та 7-го типів. Проаналізовано результати досліджень щодо поширеності цих інфекцій, шляхів зараження, варіантів клінічного перебігу та можливостей їх ...
Богачик, Нонна Анатоліївна, Венгловська, Ядвіга Вікентіївна, Меленко, Світлана Романівна, Рандюк, Юрій Олександрович, Тимощук, О.В.   +4 more
core  

How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs

Xenotransplantation, Volume 32, Issue 1, January/February 2025.
ABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Joachim Denner, Hina Jhelum, Jinzhao Ban, Ludwig Krabben, Benedikt B. Kaufer   +4 more
wiley   +1 more source

Working with Miraculous Mice: Mus musculus as a Model Organism

Current Protocols, Volume 4, Issue 10, October 2024.
Abstract The laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research.
Anick Standley, Jinhan Xie, Angelica WY Lau, Lauren Grote, Andrew J. Gifford   +4 more
wiley   +1 more source

Herpesvirus – pathogens and lifelong companions of man [PDF]

, 2011
Herpesvirusi su grupa velikih DNA virusa s karakterističnom strukturom viriona. U porodicu Herpesviridae spadaju virusi koji inficiraju sisavce, gmazove i ptice te se dijele u 3 podporodice.
Gelemanović, Andrea
core   +2 more sources