Results 71 to 80 of about 1,342 (122)

Limited availability of methods for the detection of xenotransplantation‐relevant viruses in veterinary laboratories

Xenotransplantation, Volume 31, Issue 3, May/June 2024.
Abstract Background The German Xenotransplantation Consortium is in the process to prepare a clinical trial application (CTA) on xenotransplantation of genetically modified pig hearts. In the CTA documents to the central and national regulatory authorities, that is, the European Medicines Agency (EMA) and the Paul Ehrlich Institute (PEI), respectively,
Joachim Denner
wiley   +1 more source

Roseolovirus role in the development of infectious and inflammatory diseases affecting the upper respiratory tract in children

Russian Medical Inquiry
Background: roseoloviruses, including human herpesvirus (HHV) 6A/B and HHV-7, are implicated in several diseases but remain underexplored among clinically healthy individuals. Aim: this study aims to assess the role of HHV-6A, HHV-6B, and HHV-7 in the onset of infectious and inflammatory diseases affecting the upper respiratory tract in children ...
P.V. Vlasov, T.S. Sabinina, A.D. Musyka, E.Yu. Soldatova, E.A. Domonova, O.Yu. Silveistrova, E.V. Melekhina   +6 more
openaire   +1 more source

Improving the safety of CAR‐T‐cell therapy: The risk and prevention of viral infection for patients with relapsed or refractory B‐cell lymphoma undergoing CAR‐T‐cell therapy

American Journal of Hematology, Volume 99, Issue 4, Page 662-678, April 2024.
Risk factors and prevention recommendations for viral infections in CAR T‐cell therapy. Abstract Chimeric antigen receptor (CAR) T‐cell therapy, an innovative immunotherapeutic against relapsed/refractory B‐cell lymphoma, faces challenges due to frequent viral infections.
Hu Qian, Xingcheng Yang, Tingting Zhang, Ping Zou, Yicheng Zhang, Weiwei Tian, Zekai Mao, Jia Wei   +7 more
wiley   +1 more source

A Step‐by‐Step Guide for the Production of Recombinant Fluorescent TAT‐HA‐Tagged Proteins and their Transduction into Mammalian Cells

Current Protocols, Volume 4, Issue 3, March 2024.
Abstract Investigating the function of target proteins for functional prospection or therapeutic applications typically requires the production and purification of recombinant proteins. The fusion of these proteins with tag peptides and fluorescently derived proteins allows the monitoring of candidate proteins using SDS‐PAGE coupled with western ...
Christer Abou Anny, Sébastien Nouaille, Régis Fauré, Céline Schulz, Corentin Spriet, Isabelle Huvent, Christophe Biot, Tony Lefebvre   +7 more
wiley   +1 more source

A broad wastewater screening and clinical data surveillance for virus-related diseases in the metropolitan Detroit area in Michigan

Human Genomics
Background Periodic bioinformatics-based screening of wastewater for assessing the diversity of potential human viral pathogens circulating in a given community may help to identify novel or potentially emerging infectious diseases.
Yabing Li, Brijen Miyani, Russell A. Faust, Randy E. David, Irene Xagoraraki   +4 more
doaj   +1 more source

Screening for Viruses in Indigenous Greek Black Pigs

Microorganisms
The successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum, Vasileios Papatsiros, Georgios Papakonstantinou, Ludwig Krabben, Benedikt Kaufer, Joachim Denner   +5 more
doaj   +1 more source

Protein interactions of membrane protein U24 from Roseolovirus and implications for its function

, 2016
This dissertation describes the investigation of the interactions between the tail-anchored membrane protein U24 from Human Herpesvirus type 6A (HHV-6A) and type 7 (HHV-7) and its potential binding partners. The roles that these interactions play in U24s’ function will be presented.
openaire   +1 more source

Bioinformatics-based screening tool identifies a wide variety of human and zoonotic viruses in Trujillo-Peru wastewater

One Health
Peru was one of the most affected countries during the COVID-19 pandemic. Moreover, multiple other viral diseases (enteric, respiratory, bloodborne, and vector-borne) are endemic and rising.
Brijen Miyani, Yabing Li, Heidy Peidro Guzman, Ruben Kenny Briceno, Sabrina Vieyra, Rene Hinojosa, Irene Xagoraraki   +6 more
doaj   +1 more source

Reply to “Murine Roseolovirus, Historically Known as Murine Thymic Lymphotropic Virus” [PDF]

Journal of Virology, 2017
Swapneel J. Patel, Wayne M. Yokoyama
openaire   +2 more sources

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human and Mouse Cells

Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown pathogenic in the context of xenotransplantation. Transmission of PCMV/PRV to non-human primates receiving hearts or kidneys from virus-positive pigs significantly reduced the survival time of the recipients.
Hina Jhelum, Reinhold Schäfer, Benedikt Kaufer, Joachim Denner   +3 more
openaire   +1 more source