Results 51 to 60 of about 909 (104)

Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution. [PDF]

PLoS ONE, 2016
A thorough search for bat herpesviruses was carried out in oropharyngeal samples taken from most of the bat species present in the Iberian Peninsula from the Vespertilionidae, Miniopteridae, Molossidae and Rhinolophidae families, in addition to a colony ...
Francisco Pozo, Javier Juste, Sonia Vázquez-Morón, Carolina Aznar-López, Carlos Ibáñez, Inazio Garin, Joxerra Aihartza, Inmaculada Casas, Antonio Tenorio, Juan Emilio Echevarría   +9 more
doaj   +1 more source

Virus Safety of Xenotransplantation

Viruses, 2022
The practice of xenotransplantation using pig islet cells or organs is under development to alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or organ failure.
Joachim Denner
doaj   +1 more source

The first endogenous herpesvirus, identified in the tarsier genome, and novel sequences from primate rhadinoviruses and lymphocryptoviruses. [PDF]

PLoS Genetics, 2014
Herpesviridae is a diverse family of large and complex pathogens whose genomes are extremely difficult to sequence. This is particularly true for clinical samples, and if the virus, host, or both genomes are being sequenced for the first time.
Amr Aswad, Aris Katzourakis
doaj   +1 more source

Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes

Viruses, 2017
Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry ...
Joshua G. Tweedy, Eric Escriva, Maya Topf, Ursula A. Gompels   +3 more
doaj   +1 more source

Zoonosis and xenozoonosis in xenotransplantation: A proposal for a new classification

Zoonoses and Public Health, 2023
Xenotransplantation is under development in order to alleviate the shortage of human organs for the treatment of organ failure. For many reasons, including the ability to be easily cloned and genetically modified, pigs are used as donor animals. Numerous
J. Denner
semanticscholar   +1 more source

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

Frontiers in Microbiology, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Bhupesh K. Prusty, Bhupesh K. Prusty, Nitish Gulve, Sheila Govind, Gerhard R. F. Krueger, Julia Feichtinger, Julia Feichtinger, Lee Larcombe, Richard Aspinall, Dharam V. Ablashi, Carla T. Toro, Carla T. Toro   +11 more
doaj   +1 more source

Additional file 1 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

, 2022
Additional file 1: Supplementary Fig. 1. Peripheral, neonatal MRV infection in 5XFAD mice does not accelerate Aβ plaque burden. A, Schematic of experimental paradigm (6 mpi). B, C, Percent of CD4+ and CD8+ T cells in plasma 10 dpi (B) or 6 mpi (C). D, E, HJ3.4B+ immunostaining for Aβ plaque load in the cortex. F–I, Staining and quantification for Tau5+
Bigley, Tarin M., Xiong, Monica, Ali, Muhammad, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Eteleeb, Abdallah, Harari, Oscar, Yang, Liping, Patel, Swapneel J., Cruchaga, Carlos, Yokoyama, Wayne M., Holtzman, David M.   +12 more
openaire   +1 more source

Additional file 3 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

, 2022
Additional file 3: Supplementary Fig. 3. Effects of acute, intrahippocampal MRV infection on tau pathology. A, Schematic of experimental paradigm. B – G, Staining and quantification for Tau5+ total tau (B, C, D) and AT8+ phosphorylated tau in the cortex (E, F, G). p-tau: phosphorylated tau. Scale bar: 500 μm.
Bigley, Tarin M., Xiong, Monica, Ali, Muhammad, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Eteleeb, Abdallah, Harari, Oscar, Yang, Liping, Patel, Swapneel J., Cruchaga, Carlos, Yokoyama, Wayne M., Holtzman, David M.   +12 more
openaire   +1 more source

Additional file 2 of Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains

, 2022
Additional file 2: Supplementary Fig. 2. Comparisons between MRV purified and unpurified stocks. A – C, Stocks were created from in vivo passage and collection of 7 day post neonatal infection thymi and were used directly (MRV Stock) or semi-purified (MRV Purified).
Bigley, Tarin M., Xiong, Monica, Ali, Muhammad, Chen, Yun, Wang, Chao, Serrano, Javier Remolina, Eteleeb, Abdallah, Harari, Oscar, Yang, Liping, Patel, Swapneel J., Cruchaga, Carlos, Yokoyama, Wayne M., Holtzman, David M.   +12 more
openaire   +1 more source

Limited availability of methods for the detection of xenotransplantation‐relevant viruses in veterinary laboratories

Xenotransplantation
The German Xenotransplantation Consortium is in the process to prepare a clinical trial application (CTA) on xenotransplantation of genetically modified pig hearts.
Joachim Denner
semanticscholar   +1 more source