Results 61 to 70 of about 1,335 (123)
Viruses, 2017 Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry ...
Joshua G. Tweedy +3 more
doaj +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley +1 more source
Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders
Frontiers in Microbiology, 2018 Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Bhupesh K. Prusty +11 more
doaj +1 more source
Xenotransplantation, Volume 32, Issue 1, January/February 2025.ABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Joachim Denner +4 more
wiley +1 more source
Working with Miraculous Mice: Mus musculus as a Model Organism
Current Protocols, Volume 4, Issue 10, October 2024.Abstract The laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research.
Anick Standley +4 more
wiley +1 more source
Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses
Ecology and Evolution, Volume 14, Issue 6, June 2024.We sampled 1086 bats from two, adjacent Puerto Rican caves and tested them for infection by herpesviruses, resulting in 3131 short, viral sequences. Using percent identity of nucleotides and a machine learning algorithm (affinity propagation), we categorized herpesviruses into 43 operational taxonomic units (OTUs).
Anna R. Sjodin +3 more
wiley +1 more source
Xenotransplantation, Volume 31, Issue 3, May/June 2024.Abstract Background The German Xenotransplantation Consortium is in the process to prepare a clinical trial application (CTA) on xenotransplantation of genetically modified pig hearts. In the CTA documents to the central and national regulatory authorities, that is, the European Medicines Agency (EMA) and the Paul Ehrlich Institute (PEI), respectively,
Joachim Denner
wiley +1 more source
American Journal of Hematology, Volume 99, Issue 4, Page 662-678, April 2024.Risk factors and prevention recommendations for viral infections in CAR T‐cell therapy. Abstract Chimeric antigen receptor (CAR) T‐cell therapy, an innovative immunotherapeutic against relapsed/refractory B‐cell lymphoma, faces challenges due to frequent viral infections.
Hu Qian +7 more
wiley +1 more source
Current Protocols, Volume 4, Issue 3, March 2024.Abstract Investigating the function of target proteins for functional prospection or therapeutic applications typically requires the production and purification of recombinant proteins. The fusion of these proteins with tag peptides and fluorescently derived proteins allows the monitoring of candidate proteins using SDS‐PAGE coupled with western ...
Christer Abou Anny +7 more
wiley +1 more source