Results 41 to 50 of about 1,227 (104)

Image_1_Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.TIF

open access: yes, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Richard Aspinall (348825)   +8 more
core   +1 more source

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

open access: yesMedicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source

Data_Sheet_5_Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.PDF

open access: yes, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Richard Aspinall (348825)   +8 more
core   +1 more source

Data_Sheet_4_Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.PDF

open access: yes, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Richard Aspinall (348825)   +8 more
core   +1 more source

Working with Miraculous Mice: Mus musculus as a Model Organism

open access: yesCurrent Protocols, Volume 4, Issue 10, October 2024.
Abstract The laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research.
Anick Standley   +4 more
wiley   +1 more source

Image_3_Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.TIF

open access: yes, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Richard Aspinall (348825)   +8 more
core   +1 more source

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human and Mouse Cells

open access: yes
Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown pathogenic in the context of xenotransplantation. Transmission of PCMV/PRV to non-human primates receiving hearts or kidneys from virus-positive pigs significantly reduced the survival time of the recipients.
Hina Jhelum   +3 more
openaire   +1 more source

Data_Sheet_1_Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders.PDF

open access: yes, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Richard Aspinall (348825)   +8 more
core   +1 more source

Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses

open access: yesEcology and Evolution, Volume 14, Issue 6, June 2024.
We sampled 1086 bats from two, adjacent Puerto Rican caves and tested them for infection by herpesviruses, resulting in 3131 short, viral sequences. Using percent identity of nucleotides and a machine learning algorithm (affinity propagation), we categorized herpesviruses into 43 operational taxonomic units (OTUs).
Anna R. Sjodin   +3 more
wiley   +1 more source

Limited availability of methods for the detection of xenotransplantation‐relevant viruses in veterinary laboratories

open access: yesXenotransplantation, Volume 31, Issue 3, May/June 2024.
Abstract Background The German Xenotransplantation Consortium is in the process to prepare a clinical trial application (CTA) on xenotransplantation of genetically modified pig hearts. In the CTA documents to the central and national regulatory authorities, that is, the European Medicines Agency (EMA) and the Paul Ehrlich Institute (PEI), respectively,
Joachim Denner
wiley   +1 more source

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