How, where and when to screen for porcine cytomegalovirus (PCMV) in donor pigs for xenotransplantation [PDF]
Porcine cytomegalovirus (PCMV), that is actually a porcine roseolovirus (PRV), is a common herpesvirus in domestic pigs and wild boars. In xenotransplantation, PCMV/PRV has been shown to significantly reduce the survival time of pig kidneys and hearts in
Denner, Joachim +5 more
core +1 more source
Xenoperfusion—The Transformative Role of Machine Perfusion in Xenotransplantation
ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Florian Huwyler +3 more
wiley +1 more source
Is There an Ethical Dilemma in Xenotransplantation?
ABSTRACT As clinical trials in xenotransplantation commence, the question of whether participants may withdraw from research is being intensely debated. Some authors argue that xenotransplant recipients should be subject to lifelong monitoring because of the potential risk of zoonotic or xenozoonotic infections affecting third parties.
Joachim Denner
wiley +1 more source
Effect of HHV-6 and HHV-7 Infection on the Posttransplant Process and the Development of Complications in Patients after Autologous Stem Cell Transplantation [PDF]
Publisher Copyright: © 2016 by Ilze Trociukas.The relationship between HHV-6 and HHV-7 reactivation and development of post-autologous peripheral stem cell transplantation complications was examined.
Ablashi +98 more
core +2 more sources
Abstract The choice of cell source for generating induced pluripotent stem cells (iPSCs) is influenced by several factors, including accessibility, reprogramming efficiency, and the invasiveness of the cell collection procedure. Traditional sources such as skin fibroblasts or peripheral blood mononuclear cells often require invasive sampling, which can
Laurie Martineau +4 more
wiley +1 more source
Clinical chorioamnionitis at term X: Microbiology, clinical signs, placental pathology, and neonatal bacteremia - Implications for clinical care [PDF]
Objectives: Clinical chorioamnionitis at term is considered the most common infection-related diagnosis in labor and delivery units worldwide. The syndrome affects 5-12% of all term pregnancies and is a leading cause of maternal morbidity and mortality ...
Alhousseini, Ali +24 more
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Клінічно-епідеміологічні особливості інфекцій, викликаних вірусами герпесу 6-го та 7-го типів (огляд літератури) [PDF]
У статті висвітлено сучасні уявлення про герпесвірусні інфекції, спричинені вірусами герпесу людини 6-го та 7-го типів. Проаналізовано результати досліджень щодо поширеності цих інфекцій, шляхів зараження, варіантів клінічного перебігу та можливостей їх ...
Богачик, Нонна Анатоліївна +4 more
core
First virological and pathological study of Go¨ttingen Minipigs with Dippity Pig Syndrome (DPS) [PDF]
Dippity Pig Syndrome (DPS) is a well-known but rare complex of clinical signs affecting minipigs, which has not been thoroughly investigated yet. Clinically affected animals show acute appearance of red, exudating lesions across the spine.
Denner, Joachim +13 more
core +1 more source
Humanized Mouse Models of Epstein Barr Virus Infection
Abstract The oncogenic Epstein Barr virus (EBV) is an exclusively human pathogen with related lymphocryptoviruses (γ1‐herpesviruses) only present in monkeys. Therefore, experimentation with EBV infection in a small animal model requires reconstitution or adoptive transfer of human lymphocyte populations, primarily EBV's main host cell, the human B cell.
Saskia Gertrud von Boxberg +5 more
wiley +1 more source
The Antiviral Activity of Polyphenols
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source

