Genomic Validation of PERV-C-Free Pigs to Support Xenotransplantation. [PDF]
XenotransplantationABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Benjamin NR +6 more
europepmc +2 more sources
Analyses of tissue culture adaptation of human Herpesvirus-6A by whole genome deep sequencing redefines the reference sequence and identifies virus entry complex changes [PDF]
, 2017 Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry ...
Escriva, E. +3 more
core +2 more sources
HHV-6 in liver transplantation : A literature review [PDF]
, 2017 Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis and higher rates of graft ...
Lautenschlager, Irmeli +3 more
core +1 more source
A transcriptomic insight into the human sperm microbiome through next-generation sequencing [PDF]
, 2023 Altres ajuts: Universitat Autònoma de Barcelona (UAB CF-180034, UAB/PIF2015)The purpose of this study is to provide novel information through Next Generation Sequencing (NGS) for the characterization of viral and bacterial RNA cargo of human sperm cells ...
Aiese Cigliano, Riccardo +5 more
core +1 more source
Detection of porcine cytomegalovirus, a roseolovirus, in pig ovaries and follicular fluid: implications for somatic cells nuclear transfer, cloning and xenotransplantation [PDF]
, 2023 Background Porcine cytomegalovirus (PCMV) is a porcine roseolovirus (PCMV/PRV) which is widely distributed in pigs. Transmission of PCMV/PRV in preclinical xenotransplantations was shown to significantly reduce the survival time of the pig transplants
Denner, Joachim +7 more
core +1 more source
Herpes Viral Origin of the Parsonage-Turner Syndrome: Highlighting of Serological Immune Anti-Herpes Deficiency Cured by Anti-Herpes Therapy. [PDF]
, 2015 International audienceIn 2012, a 50 year-old athletic male presented with weakness, pain and unilateral phrenic paralysis, followed by bilateral phrenic paralysis with deep dyspnea. In 2013, the Parsonage-Turner syndrome was diagnosed.
Bourée, Patrice +5 more
core +6 more sources
An Approach to Controlling Inflammation and Coagulation in Pig-to-Baboon Cardiac Xenotransplantation. [PDF]
XenotransplantationABSTRACT Introduction Inflammatory responses and coagulation disorders are a relevant challenge for successful cardiac xenotransplantation on its way to the clinic. To cope with this, an effective and clinically practicable anti‐inflammatory and anti‐coagulatory regimen is needed.
Bender M +30 more
europepmc +2 more sources
Safety of Xenotransplantation: Development of screening methods and testing for porcine viruses [PDF]
, 2018 Xenotransplantation using pig cells, tissues or organs might be a promising solution to overcome the shortage for organs suitable for allotransplantation. Because of several reasons, the pig is currently the favoured donor species.
Janich geb. Plotzki, Elena
core +1 more source
Microchimerism, PERV and Xenotransplantation [PDF]
, 2023 Microchimerism is the presence of cells in an individual that have originated from a genetically distinct individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish ...
Denner, Joachim
core +1 more source
Comparative analysis of Roseoloviruses in humans, pigs, mice, and other species [PDF]
, 2019 Viruses of the ...
Bigley, Tarin M +5 more
core +2 more sources