Results 51 to 60 of about 1,691 (122)

Clinical Xenotransplantation of Gene‐Edited Pig Organs: A Review of Experiments in Living Humans Since 2022

Medicine Bulletin, Volume 1, Issue 1, Page 77-85, June 2025.
Recent clinical trials transplanted gene‐edited pig hearts, kidneys, and a liver into eight human patients, demonstrating xenotransplantation's potential to address organ shortages. While showing promise, outcomes varied, highlighting key challenges including immune rejection and managing patient comorbidities, requiring further optimization.
Lisha Mou, Zuhui Pu, David K. C. Cooper
wiley   +1 more source

Herpesvirus – pathogens and lifelong companions of man [PDF]

, 2011
Herpesvirusi su grupa velikih DNA virusa s karakterističnom strukturom viriona. U porodicu Herpesviridae spadaju virusi koji inficiraju sisavce, gmazove i ptice te se dijele u 3 podporodice.
Gelemanović, Andrea
core   +2 more sources

Working with Miraculous Mice: Mus musculus as a Model Organism

Current Protocols, Volume 4, Issue 10, October 2024.
Abstract The laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research.
Anick Standley, Jinhan Xie, Angelica WY Lau, Lauren Grote, Andrew J. Gifford   +4 more
wiley   +1 more source

Pesquisa de herpesvírus 6 em amostras de tecido cerebral de pacientes submetidos à cirurgia como tratamento para epilepsia [PDF]

, 2011
Human herpesvirus 6 (HHV-6) is a Betaherpesvirus associated with Roseola Infantum (Exanthema Subitum) in primary infection. Due to its neurotropic characteristic and latency in the central nervous system, many reports associate HHV-6 with epilepsy ...
Andreatta, Rafaela Manfro Rorato
core  

Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses

Ecology and Evolution, Volume 14, Issue 6, June 2024.
We sampled 1086 bats from two, adjacent Puerto Rican caves and tested them for infection by herpesviruses, resulting in 3131 short, viral sequences. Using percent identity of nucleotides and a machine learning algorithm (affinity propagation), we categorized herpesviruses into 43 operational taxonomic units (OTUs).
Anna R. Sjodin, Michael R. Willig, Armando Rodríguez‐Durán, Simon J. Anthony   +3 more
wiley   +1 more source

Limited availability of methods for the detection of xenotransplantation‐relevant viruses in veterinary laboratories

Xenotransplantation, Volume 31, Issue 3, May/June 2024.
Abstract Background The German Xenotransplantation Consortium is in the process to prepare a clinical trial application (CTA) on xenotransplantation of genetically modified pig hearts. In the CTA documents to the central and national regulatory authorities, that is, the European Medicines Agency (EMA) and the Paul Ehrlich Institute (PEI), respectively,
Joachim Denner
wiley   +1 more source

Improving the safety of CAR‐T‐cell therapy: The risk and prevention of viral infection for patients with relapsed or refractory B‐cell lymphoma undergoing CAR‐T‐cell therapy

American Journal of Hematology, Volume 99, Issue 4, Page 662-678, April 2024.
Risk factors and prevention recommendations for viral infections in CAR T‐cell therapy. Abstract Chimeric antigen receptor (CAR) T‐cell therapy, an innovative immunotherapeutic against relapsed/refractory B‐cell lymphoma, faces challenges due to frequent viral infections.
Hu Qian, Xingcheng Yang, Tingting Zhang, Ping Zou, Yicheng Zhang, Weiwei Tian, Zekai Mao, Jia Wei   +7 more
wiley   +1 more source

High Torque teno virus load and outcome of patients undergoing allogeneic hematopoietic cell transplantation

Journal of Medical Virology, Volume 96, Issue 3, March 2024.
Abstract Quantification of Torque teno virus (TTV) load emerged as a marker of immunosuppression. Associations of TTV load with complications and survival after allogeneic hematopoietic cell transplantation (allo‐HCT) were controversial in published studies. In this prospective study, we aimed to identify factors influencing TTV load after allo‐HCT and
Micha Srour, Corentin Grenier, Leonardo Magro, Didier Hober, Ibrahim Yakoub‐Agha, Ilka Engelmann   +5 more
wiley   +1 more source

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does not Infect Human and Mouse Cells

Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown pathogenic in the context of xenotransplantation. Transmission of PCMV/PRV to non-human primates receiving hearts or kidneys from virus-positive pigs significantly reduced the survival time of the recipients.
Hina Jhelum, Reinhold Schäfer, Benedikt Kaufer, Joachim Denner   +3 more
openaire   +1 more source

Emergence of novel circoviruses in humans and pigs and their possible importance for xenotransplantation and blood transfusions

Xenotransplantation, Volume 31, Issue 2, March/April 2024.
Abstract Background As sequencing is becoming more broadly available, virus discovery continues. Small DNA viruses contribute to up to 60% of the overall virus load in pigs. Porcine circoviruses (PCVs) are small DNA viruses with a single‐stranded circular genome.
Tanja Opriessnig, Chao‐Ting Xiao, Nicolas J. Mueller, Joachim Denner   +3 more
wiley   +1 more source