Is There an Ethical Dilemma in Xenotransplantation? [PDF]
XenotransplantationABSTRACT As clinical trials in xenotransplantation commence, the question of whether participants may withdraw from research is being intensely debated. Some authors argue that xenotransplant recipients should be subject to lifelong monitoring because of the potential risk of zoonotic or xenozoonotic infections affecting third parties.
Denner J.
europepmc +2 more sources
OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections. [PDF]
XenotransplantationABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Denner J.
europepmc +2 more sources
Commentary: Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]
Frontiers in Veterinary ScienceJoachim Denner, Denner Joachim
exaly +2 more sources
Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights. [PDF]
J Med VirolABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Guimarães ACS +9 more
europepmc +2 more sources
Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation. [PDF]
XenotransplantationABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Huwyler F +3 more
europepmc +2 more sources
Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status [PDF]
Frontiers in Veterinary ScienceMelissa S Samuel +2 more
exaly +2 more sources
CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection [PDF]
The Journal of Immunology, 2017 Abstract A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4+ cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with ...
Swapneel J Patel, Wayne M Yokoyama
openaire +2 more sources
Possible Relation of Roseolovirus Infection with Fibromyalgia / Iespējamā Roseolovīrusu Infekcijas Saistība Ar Fibromialīiju [PDF]
Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., 2016 Abstract Fibromyalgia (FM) is a chronic widespread pain disorder that impacts 0.5%-7% of the general population worldwide. The aetiology and pathogenesis of the disease are still unknown. Human herpesvirus-6 and -7 belong to the family Herpesviridae, subfamily Betaherpesvirinae, and genus Roseolovirus and are immunomodulating viruses ...
Svetlana Čapenko +6 more
openaire +1 more source
The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses
Current Protocols, Volume 3, Issue 11, November 2023., 2023 Abstract Epitopes recognized by T cells are a collection of short peptide fragments derived from specific antigens or proteins. Immunological research to study T cell responses is hindered by the extreme degree of heterogeneity of epitope targets, which are usually derived from multiple antigens; within a given antigen, hundreds of different T cell ...
Ricardo da Silva Antunes +7 more
wiley +1 more source
How to Detect Porcine Endogenous Retrovirus (PERV) Infections in Patients After Transplantation of Pig Organs. [PDF]
XenotransplantationABSTRACT Porcine endogenous retroviruses (PERVs) are integrated into the genome of all pigs and can infect human cells in culture. However, no PERV infections have been reported in recipients following preclinical or clinical xenotransplantation or deliberate infection experiments.
Denner J +4 more
europepmc +2 more sources