Results 11 to 20 of about 807,436 (126)

Is There an Ethical Dilemma in Xenotransplantation? [PDF]

Xenotransplantation
ABSTRACT As clinical trials in xenotransplantation commence, the question of whether participants may withdraw from research is being intensely debated. Some authors argue that xenotransplant recipients should be subject to lifelong monitoring because of the potential risk of zoonotic or xenozoonotic infections affecting third parties.
Denner J.
europepmc   +2 more sources

Comprehensive Viral Detection and Profiling of Plasma Cell-Free RNA in Patients With Suspected Hemophagocytic Lymphohistiocytosis. [PDF]

J Med Virol
ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a severe, rapidly progressive disease. While viral infection is considered a common etiology of pediatric HLH, specific causative viruses other than the Epstein‐Barr virus (EBV) have been rarely identified.
Fukuda Y, Horiba K, Hashino M, Kawabe S, Miura H, Kawamura Y, Tanaka M, Suzuki T, Torii Y, Muramatsu H, Takahashi Y, Yoshikawa T, Kawada JI.   +12 more
europepmc   +2 more sources

OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections. [PDF]

Xenotransplantation
ABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Denner J.
europepmc   +2 more sources

Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights. [PDF]

J Med Virol
ABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Guimarães ACS, Gonçalves JP, Pereira NS, Bonfim FFO, Martinelli KG, Amarante MK, Yamada-Ogatta SF, Franco LC, Galhardi LCF, de Paula VS.   +9 more
europepmc   +2 more sources

Xenoperfusion-The Transformative Role of Machine Perfusion in Xenotransplantation. [PDF]

Xenotransplantation
ABSTRACT Recent advances in xenotransplantation have gained substantial public and clinical attention as genetically modified porcine organs are now being transplanted into living human recipients. While only case reports have been published to date, the first clinical trials for kidney xenotransplantation are now ongoing.
Huwyler F, Stoerzer S, Clavien PA, Tibbitt MW.   +3 more
europepmc   +2 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Detection of human herpesvirus 6 and 7 DNA in saliva from healthy adults from Rio de Janeiro, Brazil

Memorias do Instituto Oswaldo Cruz, 2010
In this study, we aimed to evaluate virus shedding in the saliva of healthy adults from the metropolitan region of the city of Rio de Janeiro, Brazil, in order to verify the prevalence of both human herpesviruses 6 and 7 (HHV-6, HHV-7). The studied group
Ivna M Magalhães, Rebeca VN Martins, João J Cossatis, Renata M Cavaliere, Larissa A Afonso, Natalia Moysés, Solange A Oliveira, Silvia MB Cavalcanti   +7 more
doaj   +1 more source

Differences in DNA Binding Specificity among Roseolovirus Origin Binding Proteins [PDF]

, 2001
The Roseolovirus genus of the Betaherpesvirinae consists of the very closely related viruses, human herpesvirus 6 variants A and B (HHV-6A and HHV-6B) plus the somewhat more distantly related human herpesvirus 7 (HHV-7).
Krug, Laurie T., Pellett, Philip E., Inoue, Naoki   +2 more
core   +1 more source

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

Frontiers in Microbiology, 2018
Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can ...
Bhupesh K. Prusty, Bhupesh K. Prusty, Nitish Gulve, Sheila Govind, Gerhard R. F. Krueger, Julia Feichtinger, Julia Feichtinger, Lee Larcombe, Richard Aspinall, Dharam V. Ablashi, Carla T. Toro, Carla T. Toro   +11 more
doaj   +1 more source

Other title: Healthcare Associated Infections annual report; Other title: Report to the legislature concerning the status of the Healthcare Associated Infections Initiative

, 2017
Annual; Began with Oct. 1, 2008.; "An Act Concerning Hospital Acquired Infections."; At head of title: State of Connecticut.; Volume for Oct.
Healthcare Associated Infections Program (Conn.)
core   +3 more sources