Chemical inducer of regucalcin attenuates lipopolysaccharide‐induced inflammatory responses in pancreatic MIN6 β‐cells and RAW264.7 macrophages [PDF]
FEBS Open Bio, 2022 We previously isolated derrisfolin A, a novel rotenoid derivative, from the stems of Derris trifoliata Lour. (Leguminosae). Here, we report that derrisfolin A induces the expression of endogenous regucalcin (RGN) protein in both pancreatic MIN6 β‐cells ...
Tomiyasu Murata +9 more
doaj +3 more sources
Boeravinone B, a natural rotenoid, inhibits osteoclast differentiation through modulating NF-κB, MAPK and PI3K/Akt signaling pathways. [PDF]
BMB Rep, 2023 Osteoporosis is a major public health concern, which requires novel therapeutic strategies to prevent or mitigate bone loss. Natural compounds have attracted attention as potential therapeutic agents due to their safety and efficacy.
Piao X +9 more
europepmc +2 more sources
Tephrosin Suppresses the Chemoresistance of Paclitaxel-Resistant Ovarian Cancer via Inhibition of FGFR1 Signaling Pathway [PDF]
Biomedicines, 2023 Ovarian cancer is the leading cause of death among gynecologic cancers. Paclitaxel is used as a standard first-line therapeutic agent for ovarian cancer.
Hee Su Kim +6 more
doaj +2 more sources
Efficient constitution of a library of rotenoid analogs active against <i>Trypanosoma cruzi</i> from a digitalized plant extract collection. [PDF]
RSC AdvNatural products (NP) have proven to be a rich source of potentially bioactive compounds, and metabolomics is the current method of choice for characterizing natural extracts.
Gaudry A +10 more
europepmc +2 more sources
UHPLC-MS/MS-GNPS based phytochemical investigation of Dryopteris ramosa (Hope) C. Chr. and evaluation of cytotoxicity against liver and prostate cancer cell lines [PDF]
Heliyon, 2022 Dryopteris ramosa (family; Dryopteridaceae) has been reported for its medicinal importance in cancer, gastrointestinal disorders, and infections. The present study aimed to investigate the detailed phytochemical profile of D.
Zia-ur-Rehman +7 more
doaj +2 more sources
Research on the Hormonomics of Three Lilium Species and Their Flavonoid Diversification and Specificity [PDF]
AntioxidantsHormonomics represents an innovative approach to plant physiology and biochemistry. We utilized hormonomics to analyze the hormone profiles of three lily bulbs.
Xuanyu He +12 more
doaj +2 more sources
LC-MS/HRMS Analysis, Anti-Cancer, Anti-Enzymatic and Anti-Oxidant Effects of Boerhavia diffusa Extracts: A Potential Raw Material for Functional Applications [PDF]
Antioxidants, 2021 Boerhavia diffusa is a great tropical plant and is widely used for various traditional purposes. In the present study, we examined the influence of solvents (dichloromethane, ethyl acetate, methanol and infusion (water)) on chemical composition and ...
Kouadio Ibrahime Sinan +12 more
doaj +2 more sources
Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa. [PDF]
PLoS ONE, 2011 BACKGROUND AND AIMS: Free radicals are implicated in the aetiology of some gastrointestinal disorders such as gastric ulcer, colorectal cancer and inflammatory bowel disease.
Gabriella Aviello +8 more
doaj +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Deguelin is a natural rotenoid that shows anti-inflammatory and antimicrobial activities. Rotenoids prevent oxidative damage and potentiate natural antioxidant activity in diabetic conditions, suggesting utility in treating diabetes and ...
Ji Chen +5 more
doaj +2 more sources
Ethnomedicinal values of Boerhaavia diffusa L. as a panacea against multiple human ailments: a state of art review [PDF]
Frontiers in Chemistry, 2023 Ethnopharmacological relevance: Therapeutic botanicals (plants and derivatives) are in use since antiquity for various health ailments. The ethnic community is the repository of the information, the multifactorial therapeutic applications of which may ...
Sarita Das +7 more
doaj +2 more sources