Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]
, 2012 The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
core +1 more source
Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers
Advanced Science, EarlyView.MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao +7 more
wiley +1 more source
Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson’s disease in rats
Bulletin of Faculty of Pharmacy Cairo University, 2017 Pyrrolidine dithiocarbamate (PDTC), a low-molecular-weight thiol antioxidant, possesses neuroprotection; however, its possible modulatory effect in Parkinson’s disease (PD) has not been tested.
Noha F. Abdelkader +4 more
doaj +1 more source
Cell cycle regulation of DNA polymerase beta in rotenone-based Parkinson's disease models. [PDF]
PLoS ONE, 2014 In Parkinson's disease (PD), neuronal cells undergo mitotic catastrophe and endoreduplication prior to cell death; however, the regulatory mechanisms remain to be defined.
Hongcai Wang +7 more
doaj +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Preimpoundment Ichthyofaunal Survey of the Piney Creek Watershed, Izard County, Arkansas [PDF]
, 1974 Piney Creek is a clear medium-size tributary of White River in a region of the Ozarks that is undergoing rapid environmental change. Piney Creek is characterized by a very diverse ichthyofauna, although increased sedimentation due to poor agricultural ...
Harp, George L., Matthews, William J.
core +2 more sources
Neuroprotective Effects of Metallothionein Against Rotenone-Induced Myenteric Neurodegeneration in Parkinsonian Mice [PDF]
, 2014 Parkinson's disease (PD) is a neurodegenerative disease with motor symptoms as well as non-motor symptoms that precede the onset of motor symptoms. Mitochondrial complex I inhibitor, rotenone, has been widely used to reproduce PD pathology in the central
Asanuma, Masato +4 more
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Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis
Advanced Science, EarlyView.DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li +16 more
wiley +1 more source
Ginseng extract G115 improves locomotor function in rotenone-induced parkinsonism rats via an antioxidant effect [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2015 Exposure to certain pesticides including rotenone, a mitochondrial complex I inhibitors, may cause the oxidative damage to the dopaminergic neurons and contribute to Parkinson’s disease.
Pailin Euaruksakul +2 more
doaj
Role of PARP-1 in mitochondroal DNA damage induced by rotenone in PC12 cells
Di-san junyi daxue xuebao, 2019 Objective To explore the effect of poly (ADP-ribose) polymerase-1 (PARP-1) on mitochondrial DNA (mtDNA) damage induced by rotenone in rat adrenal medulla pheochromocytoma PC12 cells. Methods PC12 cells were treated with various dose of rotenone.
XIAO Jingsong, HOU Guizhong, SAI Yan
doaj +1 more source