Results 71 to 80 of about 64,618 (285)

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Mitochondrial Handling of Excess Ca\u3csup\u3e2+\u3c/sup\u3e is Substrate-dependent with Implications for Reactive Oxygen Species Generation [PDF]

, 2013
The mitochondrial electron transport chain is the major source of reactive oxygen species (ROS) during cardiac ischemia. Several mechanisms modulate ROS production; one is mitochondrial Ca2+ uptake.
Aldakkak, Mohammed, Camara, Amadou K.S., Dash, Ranjan K., Stowe, David F.   +3 more
core   +1 more source

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis [PDF]

, 2016
During late gestation, villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet.
Bonder, Edward M., Faller, William J., Gao, Nan, Gumucio, Deborah L., Joshi, Shilpy, Kumar, Namit, Perekatt, Ansu O., Sansom, Owen J., Srivillibhuthur, Manasa, Verzi, Michael P., Walton, Katherine D., White, Eileen, Xing, Jinchuan, Zhou, Anbo   +13 more
core   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells

Frontiers in Molecular Neuroscience, 2020
Parkinson’s disease (PD) is a neurodegenerative disorder, and the hallmarks of this disease include iron deposition and α-synuclein (α-syn) aggregation. Hepcidin could reduce iron in the central and peripheral nervous systems.
Meiqi Li, Jianan Hu, Xiaoyu Yuan, Lihua Shen, Li Zhu, Qianqian Luo   +5 more
doaj   +1 more source

PHOTOOXYGENATION OF ROTENONE [PDF]

Chemistry Letters, 1974
Abstract In the photooxygenation of rotenone(I) in pyridine solution, two isomers of rotenolones, 6aβ, 12aβ- and 6aβ, 12aα-rotenolones (II and III), were obtained besides dehydrorotenone(V) and rotenonone(VI). As one of acidic products, a keto-acid (IVa) was also isolated.
Mitsuo Chubachi, Masayuki Hamada
openaire   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein

Neural Regeneration Research, 2018
Genistein, a potent antioxidant compound, protects dopaminergic neurons in a mouse model of Parkinson's disease. However, the mechanism underlying this action remains unknown.
Huan-Cheng Wu, Qun-Liang Hu, Shi-Jun Zhang, Yan-Min Wang, Zhan-Kui Jin, Ling-Fu Lv, Sai Zhang, Zhen-Lin Liu, Hong-Lian Wu, Ou-Mei Cheng   +9 more
doaj   +1 more source

Tucumanin, a β-hydroxy-γ-lactone bistetrahydrofuranic acetogenin from Annona cherimolia, is a potent inhibitor of mitochondrial complex I [PDF]

, 2004
A new β-hydroxy-γ-methyl-γ-lactone bistetrahydrofuranic acetogenin, tucumanin, with the infrequent symmetrical threo/trans/threo/trans/ threo relative configuration at the tetrahydrofuran rings was isolated from Annona cherimolia (Annonaceae) seeds.
Alvarez, Olga, Bardon, Alicia del Valle, Barrachina, Isabel, Bermejo, Almudena, Chahboune, Nadia, El Aouad, Noureddine, Granell, Susana, Neske, Adriana, Zafra Polo, M. Carmen   +8 more
core   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source