Results 61 to 70 of about 84,372 (264)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimal Design of a High-Speed Single-Phase Flux Reversal Motor for Vacuum Cleaners

open access: yesEnergies, 2018
This paper describes the design of a single-phase high-speed flux reversal motor (FRM) for use in a domestic application (vacuum cleaner). This machine has a simple and reliable rotor structure, which is a significant advantage for high-speed ...
Vladimir Dmitrievskii   +3 more
doaj   +1 more source

ROUND-OFF ERRORS IN FLOATING-POINT ADDITIONS

open access: yesMemoirs of the Faculty of Science, Kyushu University. Series A, Mathematics, 1985
Models of algorithms of floating-point addition are designed for chopping, correctly rounding and augmentation rounding arithmetics with finite-length accumulators. The chopping arithmetic is shown to match with the simplest software, which calculates round-off errors.
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Analytical approximate solutions for nonplanar Burgers equations by weighted residual method

open access: yesResults in Physics, 2020
In this work, analytical approximate progressive wave solutions for the generalized form of the nonplanar KdV-Burgers (KdV-B) and mKdV-Burgers (mKdV-B) equations are presented and the results are discussed.
H. Demiray, E.R. El-Zahar
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

An Objective and Efficient Method for Assessing the Impact of Reduced‐Precision Calculations On Solution Correctness

open access: yesJournal of Advances in Modeling Earth Systems, 2019
Recent studies have shown that reducing the precision of floating‐point calculations in an atmospheric model can improve the model's computational performance without affecting model fidelity, but code changes are needed to accommodate lower precision or
Shixuan Zhang   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

OrbitN: A Symplectic Integrator for Planetary Systems Dominated by a Central Mass—Insight into Long-term Solar System Chaos

open access: yesThe Astronomical Journal, 2023
Reliable studies of the long-term dynamics of planetary systems require numerical integrators that are accurate and fast. The challenge is often formidable because the chaotic nature of many systems requires relative numerical error bounds at or close to
Richard E. Zeebe
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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