Results 81 to 90 of about 117,411 (298)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Round-off error and exceptional behavior analysis of explicit Runge-Kutta methods

open access: yes, 2019
International audienceNumerical integration schemes are mandatory to understand complex behaviors of dynamical systems described by ordinary differential equations.
Boldo, Sylvie   +2 more
core   +1 more source

Balancing truncation and round-off errors in FEM: One-dimensional analysis

open access: yes, 2021
In finite element methods, the accuracy of the solution cannot increase indefinitely since the round-off error related to limited computer precision increases when the number of degrees of freedom (DoFs) is large enough.
Liu, J. (author)   +5 more
core   +1 more source

An Objective and Efficient Method for Assessing the Impact of Reduced‐Precision Calculations On Solution Correctness

open access: yesJournal of Advances in Modeling Earth Systems, 2019
Recent studies have shown that reducing the precision of floating‐point calculations in an atmospheric model can improve the model's computational performance without affecting model fidelity, but code changes are needed to accommodate lower precision or
Shixuan Zhang   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

OrbitN: A Symplectic Integrator for Planetary Systems Dominated by a Central Mass—Insight into Long-term Solar System Chaos

open access: yesThe Astronomical Journal, 2023
Reliable studies of the long-term dynamics of planetary systems require numerical integrators that are accurate and fast. The challenge is often formidable because the chaotic nature of many systems requires relative numerical error bounds at or close to
Richard E. Zeebe
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The float round-off error analysis for linear minimum variance adaptive beamforming

open access: yes, 2018
Click on the DOI link to access the article (may not be free).The phase array radar has been widely used in military due to the dramatic advance in computer technique and signal processing technology.
Wang, Dan   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

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