Results 91 to 100 of about 3,578,337 (334)
Patient Preference and Adherence, 2022 Ibrahim M Gosadi,1 Raum A Ayoub,2 Hakemah T Albrahim,2 Manar S Alhakami,2 Eilaf H Ageely,2 Rawiyah S Alwadani,2 Halah M Shayani,2 Salma A Shteafi2 1Department of Family and Community Medicine, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia ...
Gosadi IM +7 more
doaj
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Modeling importance assessment processes in non-routine decision problems [PDF]
, 2003 Het afwegingsproces moet worden onderscheiden van de uiteindelijke afweging (het belangrijkheidsoordeel ofwel de aan attributen toegekende gewichten). Het afwegingsproces betreft de denkprocessen die leiden tot de gewichten.
Heerkens, Johannes Martinus Gerardus
core +2 more sources
PROFIT: a new alternative for emission-line PROfile FITting
, 2010 I briefly describe a simple routine for emission-line profiles fitting by Gaussian curves or Gauss-Hermite series. The PROFIT (line-PROfile FITting) routine represent a new alternative for use in fits data cubes, as those from Integral Field Spectroscopy
C.L. Barbosa +30 more
core +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born
Journal of Chemical Theory and Computation, 2012 We present an implementation of generalized Born implicit solvent all-atom classical molecular dynamics (MD) within the AMBER program package that runs entirely on CUDA enabled NVIDIA graphics processing units (GPUs).
A. Götz +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source