Results 171 to 180 of about 59,227 (260)

RP-HPLC for simultaneous determination of water-soluble vitamins in leafy vegetables using ultrasonicated acid hydrolysis. [PDF]

RSC Adv
Tikeshwari, Shrivas K, Tandey K, Tejwani A, Patel AK, Sharma A.   +5 more
europepmc   +1 more source

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
A flow cytometry technique was developed to measure the binding of vancomycin‐formyl peptide conjugates to the surface of resistant Staphylococcus aureus. Binding results indicate that the labelling site of the vancomycin targeting element has a major effect on binding to the bacterial cell wall, which correlates with reduced antibiotic activity ...
Winfrey P. Y. Hoo, Jemma Gullick, Ryan F. Leung, Alex J. Fulcher, Rachel W. Cass, Julien Tailhades, Anton Y. Peleg, Jennifer A. E. Payne, Meredith O’Keeffe, Max J. Cryle   +9 more
wiley   +1 more source

Structural and Functional Insights Into (S)‐5′‐C‐Guanidinopropyl Uridine‐Modified Oligonucleotides With 2′‐O‐Methyl and 2′‐Fluoro Substitutions for RNAi Therapeutics

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Novel (S)‐5′‐guanidinopropyl uridine analogs bearing 2′‐O‐methyl or 2′‐fluoro substitutions enhance nuclease resistance and mismatch discrimination while preserving A‐form RNA structure and potent RNAi activity. These modifications provide a promising strategy for improving the stability, specificity, and therapeutic potential of siRNA‐based medicines.
Sugahara Masaki, Elsayed M. Mahmoud, Shuichi Sakamoto, Yoshihito Ueno   +3 more
wiley   +1 more source

A stability-indicating RP-HPLC method for the simultaneous quantification of brimonidine tartrate and timolol maleate in bulk drug substances and pharmaceutical dosage forms. [PDF]

Sci Rep
Mestareehi A.
europepmc   +1 more source

Improved Incorporation of Arylglycines Into Ramoplanin Sequences via Solid‐Phase Peptide Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
The incorporation of arylglycines using solid‐phase peptide synthesis remains challenging due to the sensitivity of these residues for epimerization. Here, exploring multiple conditions for the incorporation of arylglycine residues into peptides using SPPS demonstrates how small changes to current synthesis protocols can lead to significant ...
Edward Marschall, Sam Tucker, Max J. Cryle, Julien Tailhades   +3 more
wiley   +1 more source

Developing and Validating a Robust RP-HPLC Method for Metoclopramide and Camylofin Simultaneous Analysis Using Response Surface Methodology. [PDF]

Int J Anal Chem
Jawhari AH, Mohamed ZH.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, Volume 16, Issue 8, Page 1550-1562, August 2026.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

A Validated RP-HPLC Method for Monitoring Pollutants Removal during Microalgae Bioremediation of Polluted Waters. [PDF]

Bull Environ Contam Toxicol
Santos B, Araújo J, Freitas F, Sobral AJFN, Encarnação T.   +4 more
europepmc   +1 more source

Synergistic Mechanism Between Ir–Phosphinito Catalyst and HFIP Enables Asymmetric Hydrogenation of Ketones Under Acidic Conditions

Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
A cooperative mechanism between a phosphinito Ir complex and HFIP provides a low‐energy pathway for hydrogen activation. This allowed the development of a highly efficient catalytic system for the hydrogenation of ketones that operates under acidic conditions, enabling the reduction of substrates containing phenols and carboxylic acids with no added ...
Martí Sidro, Agustí Lledós, María Vicent‐Morales, Jordi Benet‐Buchholz, Giuseppe Sciortino, Antoni Riera, Xavier Verdaguer   +6 more
wiley   +1 more source

Quality-by-design based RP-HPLC analytical method for the estimation of quercetin in silver-metal organic frameworks (AgMOF): a Box-Behnken optimization approach. [PDF]

Sci Rep
Mukharya A, Mutalik S.
europepmc   +1 more source