Results 201 to 210 of about 561,328 (285)

Discovery of murayaquinone from an endophytic bacterium Streptomyces sp. AN140557 as a potent inhibitor of the pine wood nematode, Bursaphelenchus xylophilus

Pest Management Science, Volume 82, Issue 2, Page 1765-1775, February 2026.
Murayaquinone isolated from the pine endophyte Streptomyces sp. AN140557 exhibits potent, dose‐dependent nematicidal activity and egg‐hatching inhibition against the pine wood nematode. It effectively inhibited pine wilt disease in greenhouse tests, suggesting potential as a promising biocontrol agent.
Min‐Kyoung Kang, Hyeon‐Ji Kim, Jong‐Hoon Kim   +2 more
wiley   +1 more source

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Marine polyhydroxylated macrolides’ drug discovery potential is limited by structural complexity and scarce material supply, hindering structure assignment, synthesis, and biological studies. Here, we present an integrated workflow that combines chemogenomic profiling, ultra‐high‐resolution NMR‐guided structural revision and stereochemical assignment ...
Malcolm R. P. George, Lobna A. Elsadek, Max Deering, Larissa Costa de Almeida, Jasper L. Tyler, Adam Noble, Valerie J. Paul, Hendrik Luesch, Craig P. Butts, Varinder K. Aggarwal   +9 more
wiley   +2 more sources

Quality-by-Design-Driven RP-HPLC Method Development and Validation for Impurity Analysis of Elexacaftor, a Cystic Fibrosis Drug, with LC-MS/MS-Based Degradant Identification. [PDF]

ACS Omega
Raghupathi JK, Vemuri DK, Ali SM, Polisetti VK, Gundla R, Kowtharapu LP, Ramachandran D, Katari NK.   +7 more
europepmc   +1 more source

On‐Resin Pictet–Spengler Cyclization for 1,2,3,4‐Tetrahydro‐β‐carboline‐3‐carboxylate (Tcc) Peptide Synthesis With Acid‐Labile Functional Tolerance

Journal of Peptide Science, Volume 32, Issue 2, February 2026.
The constrained tryptophan (Trp) analog 1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid (Tcc) is used to restrict peptide conformation in structure–activity relationship studies. Although Pictet–Spengler cyclization of Trp and aldehydes with mineral acid gives Tcc analogs, such harsh conditions do not tolerate acid‐labile functionality.
Omer S. L. N'dri, Charity D. Yongo‐Luwawa, Xiaozheng Wei, Kajumee Bora Bhowal, Chitra P. Sadanandhan, Darince Truong, Ida Boccino, Will Maclean, Lylia Dif‐Yaiche, Zoé Villeneuve, William D. Lubell   +10 more
wiley   +1 more source

Green and white analytical approach for parallel quantification of gabapentin and methylcobalamin in medicinal products using inventive RP-HPLC technique. [PDF]

Sci Rep
Mahgoub SM, Alminderej FM, Binsaleh AY, Alsehli BR, Saleh SM, Mohamed MA.   +5 more
europepmc   +1 more source

Drug‐releasing intravesical floating technology for sequential gemcitabine and docetaxel in non‐muscle‐invasive bladder cancer

BJU International, Volume 137, Issue 2, Page 360-367, February 2026.
Objectives To develop a drug‐releasing intravesical floating technology (DRIFT) device for controlled sequential delivery of gemcitabine and docetaxel (Gem/Doce) to optimise the treatment of non‐muscle‐invasive bladder cancer (NMIBC) while enabling patient mobility and self‐removal, as sequential intravesical Gem/Doce has been increasingly utilised but
Ashley C. Rhodes, Kaitlyn A. McClintic, Emily Witt, Ikenna Nwosu, Kyle R. Balk, Colin Reis, Ian C. Sutton, Jianling Bi, Melinda Z. Fu, Michael A. O’Donnell, Vignesh T. Packiam, James D. Byrne   +11 more
wiley   +1 more source

RP-HPLC Method for Rhein Quantification in Cassia fistula L. (Fabaceae) Leaves. [PDF]

Acta Med Philipp
Rodriguez JP.
europepmc   +1 more source

Development of a Robust RP-HPLC Method for the Analysis of Ofloxacin and Nitazoxanide in Fixed-Dose Combination Products

J Chiranjeevi, Malleswarapu Mahesh
openalex   +2 more sources

Separation, Characterization and quantification of Impurities and Identification of stress degradants of Cabazitaxel by RP-HPLC and LC-ESI-MS techniques

, 2018
S. Hemchand, R. Ravi Chandra Babu, Mukthinuthalapati Mathrusri Annapurna   +2 more
openalex   +1 more source

The Content of Dietary Melatonin in 119 Food Items and Its Relationship With Chronic Diseases: Results of the CUME+ Study

Journal of Human Nutrition and Dietetics, Volume 39, Issue 1, February 2026.
ABSTRACT Background Dietary melatonin, naturally occurring in plant‐ and animal‐based foods, has been linked to beneficial effects on sleep, mood and metabolic health. Although evidence suggests that food‐derived melatonin may elevate circulating levels, few studies have assessed its intake through habitual diets or explored associations with chronic ...
Gilmara Alves Zanirate, Josefina Bressan, Arieta Carla Gualandi Leal, Adriano Marçal Pimenta, Helen Hermana Miranda Hermsdorff   +4 more
wiley   +1 more source