Results 81 to 90 of about 561,328 (285)

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source

Evaluation of l-dopa, proximate composition with in vitro anti-inflammatory and antioxidant activity of Mucuna macrocarpa beans: A future drug for Parkinson treatment

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To investigate L-3, 4-dihydroxyphenylalanine (l-dopa, anti-Parkinson drug), anti-inflammatory activity, proximate nutritional composition and antioxidant potential of Mucuna macrocarpa (M. macrocarpa) beans.
Chetan Aware, Ravishankar Patil, Swaroopsingh Gaikwad, Shrirang Yadav, Vishwas Bapat, Jyoti Jadhav   +5 more
doaj   +1 more source

Mapping of Complete Set of Ribose and Base Modifications of Yeast rRNA by RP-HPLC and Mung Bean Nuclease Assay

PLoS ONE, 2016
Ribosomes are large ribonucleoprotein complexes that are fundamental for protein synthesis. Ribosomes are ribozymes because their catalytic functions such as peptidyl transferase and peptidyl-tRNA hydrolysis depend on the rRNA.
Jun Yang, Sunny Sharma, Peter Watzinger, Johannes David Hartmann, P. Kötter, K. Entian   +5 more
semanticscholar   +1 more source

Understanding the Interplay Between Thermal Activation, Diffusion, and Phase Segregation of Molecular Dopants Blended with Polymeric Semiconductors

Advanced Electronic Materials, EarlyView.
The use of air stable but thermally labile molecules provides an efficient strategy for the N‐type doping of organic semiconductors with relatively low electron affinities. Design criteria for efficient dopants should also take into account diffusion and phase segregation that cannot be decoupled from thermally activated doping.
Francesca Pallini, Sara Mattiello, Mauro Sassi, Gabriele Paoli, Giuseppe Mattioli, Pietro Rossi, Giulia Coco, Alberto D. Scaccabarozzi, Brian Minki Kim, Pietro Mariani, Hiba Wakidi, Sadie M. Flagg, Massimiliano D'Arienzo, Mario Caironi, Thuc‐Quyen Nguyen, Luca Beverina   +15 more
wiley   +1 more source

N-linked oligosaccharides obtained from glycoproteins of the lichens Sticta tomentosa and Sticta damaecornis

Eclética Química, 2018
The lichens Sticta tomentosa and Sticta damaecornis were extracted to obtain glycoproteins. The extracts were fractionated with 30-80% saturation (NH4)2SO4. The fractions were reduced, alkylated and after dialysis the material were digested with trypsin.
Patrícia Fidelis de Oliveira, Flávia Doná, Marcelo Marcelli, Marilsa Cardoso, Maria de Lourdes Corradi da Silva   +4 more
doaj   +1 more source

A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies

Journal of Pharmaceutical and Biomedical Analysis, 2022
T. Reçber, S. Timur, Sevilay Erdoğan Kablan, F. Yalçın, T. C. Karabulut, R. Neslihan Gürsoy, H. Eroğlu, S. Kır, E. Nemutlu   +8 more
semanticscholar   +1 more source

Method development, validation, and stability studies of teneligliptin by RP-HPLC and identification of degradation products by UPLC tandem mass spectroscopy

Journal of Analytical Science and Technology, 2016
BackgroundTeneligliptin is a new FDA approved drug for treating Diabetes Mellitus. There are no reported evidences for its degradation products during stability studies and their effects on humans.MethodsA simple and new stability indicating RP-HPLC ...
T. N. V. G. Kumar, S. Vidyadhara, N. Narkhede, Y. S. Silpa, M. Lakshmi   +4 more
semanticscholar   +1 more source

SIMPLE QUANTIFIED AND VALIDATED STABILITY INDICATING STRESS DEGRADATION STUDIES OF ORAL ANTI-DIABETIC AGENT DAPAGLIFLOZIN BY RP-HPLC METHOD

, 2022
Arulselvan Murugesan, Mukthinuthalapati Mathrusri Annapurna   +1 more
openalex   +2 more sources

Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase (SMS) gene, resulting in decreased or ...
Elizabeth A. VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell, Luigi Boccuto, Charles Schwartz, Anthony E. Pegg, Angela Peron, Victor Faundes, Mythily Ganapathi, Wendy K. Chung, Alban Ziegler, Floris Hofstede, Clément Prouteau, Katharina Steindl, Colleen Olson, Orrin Devinsky, Teresa L. Mastracci, Robert A. Casero Jr., Tracy Murray Stewart, Susan Gilmour, Teri Koerner, Mary Jo Kutler, Surender Rajasekaran, Julianne Michael, André S. Bachmann, Caleb P. Bupp   +26 more
wiley   +1 more source

RP-HPLC Determination of Raloxifene in Pharmaceuticl Tablets

E-Journal of Chemistry, 2006
A reverse phase HPLC method is developed for the determination of Raloxifene in pharmaceutical dosage forms. Chromatography was carried out on an inertsil C18 column using a mixture of acetonitrile and phosphate buffer (30:70 v/v) as the mobile phase at ...
P. Venkata Reddy, B. Sudha Rani, G. Srinu Babu, J. V. L. N. Seshagiri Rao   +3 more
doaj   +1 more source