Results 121 to 130 of about 3,138,640 (295)

Pre-rRNA processing pathways in budding yeast.

, 2014
(A) Structure of the 35S pre-rRNA, showing the location of cleavage site A2. (B) Pre-rRNA processing pathways via nascent transcript cleavage (NTC) and released transcript cleavage (RTC).
Sarah L. French (379931), Konstantin Axt (519241), Ann L. Beyer (379937), David Tollervey (25374)   +3 more
core   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

eLife
We investigated the role of the nucleolar protein Treacle in organizing and regulating the nucleolus in human cells. Our results support Treacle’s ability to form liquid-like phase condensates through electrostatic interactions among molecules.
Artem K Velichko, Nadezhda V Petrova, Dmitry A Deriglazov, Anastasia P Kovina, Artem V Luzhin, Eugene P Kazakov, Igor I Kireev, Sergey Razin, Omar L Kantidze   +8 more
doaj   +1 more source

Tetrahymena ribozyme disrupts rRNA processing in yeast.

Journal of Biological Chemistry, 1994
The intervening sequence (IVS) of Tetrahymena thermophila nucleolar DNA interrupts a highly conserved sequence in the RNA core structure of the large ribosomal subunit. This location in nuclear DNA is unusual as most group I introns are in mitochondrial and chloroplast DNA.
L, Good, S A, Elela, R N, Nazar
openaire   +2 more sources

Processing of rRNA is altered in L166P overexpressing cells.

, 2012
(A) Schematic diagram showing pre-rRNA structure and processing steps. Positioning of A0, 1 and 4 cleavage sites on rRNA processing intermediates is shown. ETS, external transcribed spacer; ITS, internal transcribed spacer.
Milena Pinto (169682), Marco Dal Ferro (169679), Silvia Zucchelli (169692), Sandra Vilotti (103724), Stefano Gustincich (169690), Marta Codrich (169674), Licio Collavin (169687), Isidro Ferrer (169684)   +7 more
core   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells

Nature Communications
Ribosome biogenesis plays a pivotal role in maintaining stem cell homeostasis, yet the precise regulatory mechanisms governing this process in mouse embryonic stem cells (mESCs) remain largely unknown.
Xiuqin Wang, Gongcheng Hu, Lisha Wang, Yuli Lu, Yanjiang Liu, Shengxiong Yang, Junzhi Liao, Qian Zhao, Qiuling Huang, Wentao Wang, Wenjing Guo, Heying Li, Yu Fu, Yawei Song, Qingqing Cai, Xiaofei Zhang, Xiangting Wang, Yue-Qin Chen, Xiaorong Zhang, Hongjie Yao   +19 more
doaj   +1 more source

HIV-1 infection affects pre-rRNA processing.

, 2014
(A) Schematic representation of the pre-rRNA processing in mammals [50]. (B) Northern Blot analysis of total RNA isolated from infected Jurkat cells and mock cells using an ITS1 rRNA specific probe. (C) Quantitation of the signals of Northern experiments
Elisa Orecchini (668369), Nicolas De Jay (668372), Claudia L. Kleinman (120196), Alessandro Michienzi (668373), Margherita Doria (668368), Silvia Galardi (668371), Erica Giuliani (668370)   +6 more
core   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

RNA polymerase I mutant affects ribosomal RNA processing and ribosomal DNA stability

RNA Biology
Transcription is a major contributor to genomic instability. The ribosomal RNA (rDNA) gene locus consists of a head-to-tail repeat of the most actively transcribed genes in the genome.
Christophe Normand, Christophe Dez, Lise Dauban, Sophie Queille, Sarah Danché, Sarra Abderrahmane, Frederic Beckouet, Olivier Gadal   +7 more
doaj   +1 more source