Results 151 to 160 of about 3,138,640 (295)

Analysis of rRNA processing and degradation.

, 2013
(A) Diagram illustrating the 5.8S rRNA processing intermediates and the rRNA maturation by-product generated from the 5ʹ ETS (P-Pʹ) compared with the 35S precursor [27]. Horizontal red arrows represent the positions of oligonucleotide probes used in this
Naoyoshi Kumakura (481400), Yuichiro Watanabe (245364), Masayuki Tsuzuki (481402), Atsushi Takeda (18203), Hiroka Otsuki (481401)   +4 more
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2. [PDF]

Mov Disord, 2021
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD.   +13 more
europepmc   +1 more source

Defining the impact of rRNA processing on nucleolar organization and function

SUMMARY The eukaryotic nucleolus is a highly organized, multilayered structure essential for ribosomal RNA (rRNA) processing and ribosome assembly. However, how the sequential steps of rRNA maturation, particularly the series of endonucleolytic cleavages, contribute to maintaining nucleolar architecture remains poorly understood.
Maria Saraí Mendoza-Figueroa, Ellen Lavorando, Yulia Gonskikh, Charles Antony, Heidi Elashal, Anthony Yulin Chen, Hsin-Yao Tang, Dawn Carone, Vikram R. Paralkar, Kathy Fange Liu   +9 more
openaire   +3 more sources

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

White and green striate leaves 1, predicted to encode a 16S rRNA processing protein, plays a critical role in the processing of chloroplast ribosomes in maize (Zea mays L.). [PDF]

Mol Breed, 2023
Li Q, Du J, Qiao Z, Pan C, He W, Zhang L, Li X, Nie Y, Li X, Pan G, Zhang Z, Li G, Ding H.   +12 more
europepmc   +1 more source

RNA gel blot analysis of pre-rRNA processing.

, 2016
(A) The structure of primary rRNA transcript in Arabidopsis. p1 and p2 probes, which specifically bind to 5’ETS and ITS1, respectively, were used for RNA blots. (B), (C) RNA gel blot analysis of 35S pre-rRNA processing.
Yuelin Liu (3172434), Daisuke Tabata (3172437), Ryozo Imai (176667)   +2 more
core   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity. [PDF]

Nucleic Acids Res, 2022
Szaflarski W, Leśniczak-Staszak M, Sowiński M, Ojha S, Aulas A, Dave D, Malla S, Anderson P, Ivanov P, Lyons SM.   +9 more
europepmc   +1 more source