Results 131 to 140 of about 142,389 (277)

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

It is not just about the training: rethinking strategies to strengthen the global emergency response workforce

BMJ Global Health
Introduction Public health rapid response teams (RRTs) are critical to timely and effective emergency response. The US Centers for Disease Control and Prevention (CDC) has trained country-level public health emergency managers on RRT programme design ...
Mays Shamout, Ashley Lauren Greiner, Dante Bugli, Adela Hoffman, Sonya Panjwani, Mariama Tejan, Cassandra Boutelle, Claire Corkish, Tasha Stehling-Ariza, Hannah Lofgren, Coralie GIESE   +10 more
doaj   +1 more source

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Geriatric Residents' Perceptions of Training for Good Dying: A Qualitative Case Study in Colombia

The Clinical Teacher, Volume 23, Issue 3, June 2026.
ABSTRACT Introduction Death is a universal phenomenon influenced by cultural, social and religious factors. Despite its relevance to medical practice, geriatric residents often lack formal education on how to support patients in the dying process. Methods A qualitative case study design was conducted at a tertiary care hospital in Bogotá, Colombia ...
Cristian Camilo Llano Ceballos, Nelson Julian Quiroga Laverde, Martha Patricia Montoya Montoya, Karin Natalia Perdomo Nuñez   +3 more
wiley   +1 more source

Molecular Methods for Rare Hemoglobinopathy Cases: First Brazilian Report of Pediatric Siblings with Hb O‐Arab and Alpha‐Thalassemia

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk, Amanda Cristina Meneguetti Berti, Bárbara Braga Vieira Marques, Victoria Simões Bernardo, Flaviene Felix Torres, Ingrid Souza Dias, Vanessa da Silveira Ramos de Castro, Gabriela Alves Bernardino, Danilo Grünig Humberto da Silva, Edis Belini‐Júnior   +9 more
wiley   +1 more source

Quality by Design‐Based Development of a Robust LC Method for Simultaneous Estimation of Process‐ and Degradation‐Related Impurities in Rifapentine Drug Product for the Treatment of Active and Latent Tuberculosis

Biomedical Chromatography, Volume 40, Issue 5, May 2026.
ABSTRACT A precise, robust, and stability‐indicating liquid chromatographic (LC) method coupled with a photodiode array (PDA) detector was developed and validated for the quantitative estimation of rifapentine, an essential therapeutic agent for both active and latent tuberculosis (TB).
Siva Prasad Korikana, Sreenivasa Rao Battula, Naresh Konduru, Aravind Kurnool, Divya Kumar Vemuri, Venkata Lakshamana Sagar Dantinapalli   +5 more
wiley   +1 more source

Variable Sampling Area RRT Algorithm Based on Limiting Joint Angle for Robotic Arm Path Planning

IEEE Access
It is an important capacity to plan an optimal working path without collision for robotic arms. Rapid exploration random tree (RRT) is a popular algorithm in the field of path planning. However, the high computational cost caused by directly using RRT to
Zhi-Jie Ding, Xin-Jia Meng, Li-Xiang Zhang, Yi-Bin Guo, Meng-Qiu Chen, Shi-Hang Zhen   +5 more
doaj   +1 more source

From transporter to motor: Evolutionary and structural insights into the emergence of prestin's area‐motor activity in mammals

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Prestin, a member of the SLC26A family, is essential for the electromotility of mammalian outer hair cells, converting voltage changes into mechanical work. In contrast, nonmammalian orthologues function as anion transporters. To investigate the molecular and structural basis of this functional divergence, we performed ancestral sequence ...
Nicolás Fuentes‐Ugarte, Tiaren Ruiz‐Rojas, Felipe Garcia‐Olave, Alvaro Ruiz‐Fernandez, Jose Antonio Garate, Victor Castro‐Fernandez, Raul Araya‐Secchi   +6 more
wiley   +1 more source

Synthesis of Conjugated Linear and Cyclic Polyynes by Selective Alkyne Metathesis

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
The formation of polyynes with an odd number of conjugated triple bonds is challenging, particularly for complex architectures since most established methods rely on irreversible C–C bond‐forming reactions. To address this, we have developed the synthesis of triynes via alkyne metathesis.
Julien Escudero, Jonathan Long, Dylan Bouëtard, Jennifer Morvan, Mehdi Koohgard, Angelika Neitzel, Dirk Bockfeld, Shedrack Nwachukwu, Thierry Roisnel, Rik R. Tykwinski, Matthias Tamm, Marc Mauduit, Yann Trolez   +12 more
wiley   +2 more sources

RRT-connect: An efficient approach to single-query path planning

Proceedings 2000 ICRA. Millennium Conference. IEEE International Conference on Robotics and Automation. Symposia Proceedings (Cat. No.00CH37065), 2000
J. Kuffner, S. LaValle
semanticscholar   +1 more source