Results 61 to 70 of about 33,025 (207)

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

The Landscape of Biomarkers in ICU‐Associated AKI: From Protein Markers to Cell‐Free Nucleic Acids

Journal of Clinical Laboratory Analysis, EarlyView.
Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Qi Zhu, Feng Yang, Hua Zheng, Xinxin Guo, Zhijin Chen, Limin Chen, Daoli Wang, Jiaqi Wang, Xinmeng Wang, Zhiyuan Huang, Zhenhua Ji   +10 more
wiley   +1 more source

Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High‐MELD Recipients: A Single‐Center Retrospective Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background and Purpose While normothermic machine perfusion (NMP) has benefits over static cold storage (SCS), its efficacy in high‐acuity recipients with high Model for End‐Stage Liver Disease (MELD) scores, particularly using a back‐to‐base application model, is not well established.
Yuzuru Sambommatsu, Daisuke Imai, Kush Savsani, Mallika Datta, Junpei Tarashi, Jacob Hallesy, Samuel Wolfe, Isao Yokota, Seung Duk Lee, David A. Bruno   +9 more
wiley   +1 more source

The impact of a vancomycin intervention on vancomycin‐associated nephrotoxicity in children: a quality improvement initiative

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Vancomycin is first‐line treatment for methicillin‐resistant Staphylococcus aureus (MRSA) infections. However, despite guideline recommendations, there is no evidence that targeting vancomycin trough concentrations of ≥15 mg/L in children confers clinical benefit and is associated with vancomycin‐associated nephrotoxicity (VAN ...
Megan R. Nettleton, Hwi‐Eun Mary Shim, Joanne Abbotsford, Zoy Goff, Briony Hazelton, Matthew O'Brien, Tenielle Porter, Thomas Snelling, Daniel K. Yeoh, Asha C. Bowen, Christopher C. Blyth, Anita J. Campbell   +11 more
wiley   +1 more source

In-Hospital Survival and Neurological Recovery Among Patients Requiring Renal Replacement Therapy in Post–Cardiac Arrest Period

Kidney International Reports, 2019
Objectives: Acute kidney injury (AKI) is common after cardiac arrest (CA). Few data exist on survival and neurological outcomes measured at hospital discharge of patients with severe AKI requiring renal replacement therapy (RRT) within the first 72 hours
Shivani Ghoshal, Vivian Yang, Daniel Brodie, Jai Radhakrishnan, David J. Roh, Soojin Park, Jan Claassen, Sachin Agarwal   +7 more
doaj   +1 more source

Dosing vitamin C in critically ill patients with special attention to renal replacement therapy: a narrative review

Annals of Intensive Care, 2020
Rationale/methods The primary aim of the present contribution is to find a literature-based agreement on dose adjustments of vitamin C in critically ill patients undergoing renal replacement therapy (RRT). Available data/study results Critical illness is
Patrick M. Honore, Herbert D. Spapen, Paul Marik, Willem Boer, Heleen Oudemans-van Straaten   +4 more
doaj   +1 more source

Effect of Case Variation on Mastoidectomy Training Using 3D‐Printed Temporal Bones Models—A Prospective, Randomized Trial

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate effects of repeated training with anatomically varied versus identical 3D‐printed models on skill acquisition, cognitive load, and skill retention in novice mastoidectomy trainees. Study Design A prospective, randomized, controlled, educational trial conducted April to September 2024 including a 3‐month retention test.
Adam Omari, Andreas Frithioff, Anders Nøhr, Mads S. Sørensen, Steven A. W. Andersen   +4 more
wiley   +1 more source

HAS-RRT: RRT-Based Motion Planning Using Topological Guidance

IEEE Robotics and Automation Letters
8 pages; Accepted at RA-L, April ...
Diane Uwacu, Ananya Yammanuru, Keerthana Nallamotu, Vasu Chalasani, Marco Morales 0001, Nancy M. Amato   +5 more
openaire   +2 more sources

Automated Lawn Maintenance: An Agronomic and Operational Review of Turf Health, Biodiversity, and Field Performance

Journal of Field Robotics, EarlyView.
ABSTRACT Grass mowing is one of the most resource‐consuming activities in green maintenance, whether in private areas such as home gardens or in public spaces like urban parks. In recent years, concerns related to climate change, human health, and sustainability have become increasingly prominent in green maintenance, leading manufacturers and industry
Andrea Palladini, Lorenzo Guerrini, Marco Fontanelli, Lucia Bortolini   +3 more
wiley   +1 more source

Uplift modeling to predict individual treatment effects of renal replacement therapy in sepsis-associated acute kidney injury patients

Scientific Reports
Renal replacement therapy (RRT) is a crucial treatment for sepsis-associated acute kidney injury (S-AKI), but it is uncertain which S-AKI patients should receive immediate RRT. Identifying the characteristics of patients who may benefit the most from RRT
Guanggang Li, Bo Li, Bin Song, Dandan Liu, Yue Sun, Hongyan Ju, Xiuping Xu, Jingkun Mao, Feihu Zhou   +8 more
doaj   +1 more source