Results 71 to 80 of about 164,355 (372)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households [PDF]

, 2019
Respiratory syncytial virus is the leading cause of lower respiratory tract infection among infants. RSV is a priority for vaccine development. In this study, we investigate the potential effectiveness of a two-vaccine strategy aimed at mothers-to-be ...
Agoti, Anderson, Anderson, Atkins, Ball, Bhattacharyya, Brand, Chin, Cohen, Dempster, Diekmann, Domachowske, Geard, Glass, Glezen, Graham, Grimmett, Hall, Hall, Hall, Hall, Henderson, Hinch, Hogan, House, House, Keeling, Keeling, King, Kinyanjui, Kinyanjui, Kiti, KNBS, Kurtz, Kurtz, Miller, Modjarrad, Moore, Mossong, Munywoki, Nair, Nokes, Nokes, NovaVax, Ohuma, O’Neill, Pan-Ngum, PATH, Paynter, Paynter, Pitzer, Poletti, Prem, Rackauckas, Rock, Scott, Scott, Storn, Sun, White, White, World Health Organization, Yamin, Zhu   +63 more
core   +1 more source

Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection

npj Vaccines, 2020
The RSV Fusion (F) protein is a target for neutralizing antibody responses and is a focus for vaccine discovery; however, the process of RSV entry requires F to adopt a metastable prefusion form and transition to a more stable postfusion form, which ...
Amy S. Espeseth, P. Cejas, Michael P. Citron, Dai Wang, D. Distefano, Cheryl Callahan, Gregory O ’ Donnell, Jennifer D Galli, Ryan Swoyer, Sinoeun Touch, Zhiyun Wen, J. Antonello, Lan Zhang, Jessica Flynn, K. Cox, D. Freed, K. Vora, Kapil Bahl, Andrew H. Latham, Jeffrey S. Smith, Marian E. Gindy, G. Ciaramella, D. Hazuda, C. Shaw, A. Bett   +24 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Role and Virology of RSV and RSV RNA Polymerase

The FASEB Journal, 2021
Respiratory syncytial virus (RSV) is a highly contagious, respiratory virus that commonly infects children under the age of five. RSV infections can present as cold‐like symptoms which include a runny nose, coughing, and fever among other common symptoms; however, RSV can cause more severe infections such as bronchiolitis and ...
Tina Link, Lan Nguyen, Avary Andrews, Joseph Fisher, Abhishek Kona, Aryn Wright   +5 more
openaire   +1 more source

Kinetic Insights into Precursor‐Assisted Soft Sphere Close Packing Revealed by In Situ GISAXS with Implications for Gas Sensing

Advanced Functional Materials, EarlyView.
The versatile precursor‐assisted soft sphere close packing during slot‐die coating is investigated with in situ X‐ray scattering. The soft crystallization pathways towards a close packing involve multistep structural transitions such as surface nucleation, in‐plane, and out‐of‐plane crystallization.
Guangjiu Pan, Wenhe Xie, Suzhe Liang, Ting Tian, Shanshan Yin, Lixing Li, Altantulga Buyan‐Arivjikh, Jinsheng Zhang, Thomas Baier, Zhuijun Xu, Matthias Schwartzkopf, Sarathlal Koyiloth Vayalil, Stephan V. Roth, Yonghui Deng, Peter Müller‐Buschbaum   +14 more
wiley   +1 more source

The Effect of Relative Sediment Volume on Sheet Properties of Coated Paper [PDF]

, 1967
The degree of dispersion of pigment has been claimed to be an important variable in the determination of sheet properties such as smoothness and gloss. The degree of dispersion of a pigment can be related to relative sediment volume (RSV) by comparison ...
Chalfin, James A.
core   +1 more source

Clinical severity of RSV bronchiolitis

Health Science Reports, 2022
AbstractBackgroundStudies comparing the severity of respiratory syncytial virus (RSV) bronchiolitis to other viruses are inconclusive. Our study aimed to compare the severity of bronchiolitis according to the virus.MethodsData were collected from 1152 infants under one year of age admitted to Children's hospital for Wales, over the winter months of ...
Faris Hussain, Margarita Delgado Thompson, David Vick, Jack West, Martin Edwards   +4 more
openaire   +3 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Differences Between RSV A and RSV B Subgroups and Implications for Pharmaceutical Preventive Measures

Infectious Disease and Therapy
Understanding the differences between respiratory syncytial virus (RSV) subgroups A and B provides insights for the development of prevention strategies and public health interventions.
C. Nuttens, Juliette Moyersoen, Daniel Curcio, Zuleika Aponte-Torres, Marc Baay, H. Vroling, B. Gessner, Elizabeth Begier   +7 more
semanticscholar   +1 more source