Results 91 to 100 of about 8,739 (269)
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Artificial selection increased body weight but induced increase of runs of homozygosity in Hanwoo cattle [PDF]
, 2018 Artificial selection has been demonstrated to have a rapid and significant effect on the phenotype and genome of an organism. However, most previous studies on artificial selection have focused solely on genomic sequences modified by artificial selection
Heebal Kim (9991) +27 more
core +1 more source
, 2020 Realized inbreeding coefficients calculated from 3,954 SNPs using the RZooRoH model in three North American populations of sable antelope. Each bar represents an individual, displaying overall individual inbreeding coefficients (y-axis) and the ...
Rebecca Gooley (8365797)
core +1 more source
Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity
Advanced Science, EarlyView.We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu +17 more
wiley +1 more source
BMC Evolutionary Biology, 2018 Background Commercial whaling caused extensive demographic declines in many great whale species, including gray whales that were extirpated from the Atlantic Ocean and dramatically reduced in the Pacific Ocean.
Anna Brüniche-Olsen +6 more
doaj +1 more source
A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice
Advanced Science, EarlyView.A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing +26 more
wiley +1 more source
BMC GenomicsBackground The species Capra hircus encompasses numerous breeds that exhibit a high level of phenotypic and genetic variability, resulting from environmental adaptation and artificial selection for meat, milk, and fiber production.
Stefano Pallotti +7 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
What do we mean by runs of homozygosity? Assessing effect of parameters involved in their detection [PDF]
, 2016 What do we mean by runs of homozygosity? Assessing effect of parameters involved in their detection. 67.
Fernández, J. +1 more
core +6 more sources
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source