Results 171 to 180 of about 27,021 (267)

Editorial: Advancement of RWD/RWE utilization for enhancing drug development and benefit/risk assessment. [PDF]

Front Pharmacol
Uyama Y, Bérard A, Chan KA.
europepmc   +1 more source

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

BIRTH: Bayesian integration of real-world data for trials with hybrid arms. [PDF]

BMC Med Res Methodol
Wang W, Chen X, Li B, Jiang L, Yan F.
europepmc   +1 more source

Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v3

D8.3-D8.7, reported in 5 deliverables, each one being an update of the previous one, aim to: (a) reflect the number of participants enrolled prospectively on a biannual basis until the end of the study and verify ethical RWD acquisition following informed consent and IRB approval; (b) document the amount of RWD reflective of our CoBraD Protocol ...
openaire   +1 more source

Posterior parietal cortex oscillatory activity reflects persistent spatial memory impairments induced by early hippocampal amyloidosis in male mice

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of the spatiotemporal progression of the deleterious effects of early amyloidosis. Beginning as early as 1 h after i.c.v. injection of oligomeric Aβ1‐42, alterations in hippocampal function emerge, including aberrant oscillatory activity, deficits in synaptic plasticity and impairments in habituation ...
Souhail Djebari, Ana Contreras, Victor Castro‐Andrés, Raquel Jimenez‐Herrera, Guillermo Iborra‐Lázaro, Raudel Sánchez‐Campusano, Lydia Jiménez‐Díaz, Juan D. Navarro‐López   +7 more
wiley   +1 more source

Realising precision oncology through shared real-world data infrastructure. [PDF]

Acta Oncol
Bjerrum A, Fanø A, Lassen U.
europepmc   +1 more source

Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage -v1

D83D87 reported in 5 deliverables each one being an update of the previous one aim to a reflect the number of participants enrolled prospectively on a biannual basis until the end of the study and verify ethical RWD acquisition following informed consent and IRB approval b document the amount of RWD reflective of our CoBraD Protocol acquired from ...
openaire   +1 more source

Dynamic Vibration Analysis and Suppression Research of Reamer String While Drilling

Shiyou jixie
In the application of ream while drilling technology， there are still several issues such as severe vibration of drill string system leading to cutter fragmentation and thread joint failure， complex stress state of long string under complex drilling ...
Hou Fuxiang, Yu Fusheng, Zhang Yanping, Li Jiayuan, Guan Ning, Li Yang   +5 more
doaj  

Bridging evidence worlds: policy and practice pathways for integrating clinical trials and real-world data in drug development and HTA. [PDF]

Front Pharmacol
Sagkriotis A.
europepmc   +1 more source

Determining the Survival Impact and Cost‐Effectiveness of Multi‐Gene Panel Sequencing in Metastatic Colorectal Cancer With Super Learning Approaches

Health Services Research, Volume 61, Issue 2, April 2026.
ABSTRACTObjectiveTo determine the effectiveness and cost‐effectiveness of multi‐gene panel sequencing compared to single‐gene KRAS testing for metastatic colorectal cancer (mCRC).Study Setting and DesignBritish Columbia, Canada (BC) is a provincial single‐payer public healthcare system, and it was the first province to publicly reimburse multi‐gene ...
Emanuel Krebs, Deirdre Weymann, Howard J. Lim, Stephen Yip, Dean A. Regier   +4 more
wiley   +1 more source