Results 211 to 220 of about 27,021 (267)

R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 24. [PDF]

J Comp Eff Res
Arora P, Ramagopalan SV.
europepmc   +1 more source

Participant recruitment, Pre-existing RWD access, Prospective RWD acquisition and secure storage & Pilots Evaluation and Impact Assessment -final

D8.3-D8.7, reported in 5 deliverables, each one being an update of the previous one, aim to: (a) reflect the number of participants enrolled prospectively on a biannual basis until the end of the study and verify ethical RWD acquisition following informed consent and IRB approval; (b) document the amount of RWD reflective of our CoBraD Protocol ...
openaire   +1 more source

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, Volume 7, Issue 2, March 2026.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

A Retrospective Analysis of the Clinical Characteristics and Treatment Patterns Among Individuals with Diabetes Receiving Insulin Therapy in Japan: The Insulin JP2DB Study. [PDF]

Diabetes Ther
Fukui M, Tsuboi S, Yamamoto Y, Terauchi Y.   +3 more
europepmc   +1 more source

Identification of relevant RWD sources in partner countries

Identification of relevant RWD sources in partner ...
openaire   +1 more source

Harmonizing Logical Observation Identifiers Names and Codes (LOINC) Codes and Units in Real-World Oncology Data: Method Development and Evaluation.

JMIR Med Inform
Naliyatthaliyazchayil P, Stenerson T.
europepmc   +1 more source

Opportunities and risks associated with external comparator cohorts in clinical drug development in hematology. [PDF]

Blood Cancer J
Baggio D, Hawkes EA, Simonsen MR, El-Galaly TC.   +3 more
europepmc   +1 more source

Podocyte‐Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Podocyte injury and endothelial cell dysfunction are the hallmarks of glomerular disease. How these two events are connected remains largely unknown. This study aimed to delineate the role of extracellular vesicles (EVs) in mediating podocyte‐endothelial communication in glomerular disease.
Zhao Liu, Xi Liu, Xin Wen, Siyu Yan, Meizhi He, Jie Xu, Zhanji Zhan, Haili Zhu, Huishi Tan, Nan Jia, Youhua Liu   +10 more
wiley   +1 more source

R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 23. [PDF]

J Comp Eff Res
Arora P, Ramagopalan SV.
europepmc   +1 more source

Peroxisome Proliferator‑Activated Receptor Gamma Coactivator‑1α Deficiency in Hippocampal Astrocytes Underlies Enhanced Fear Memory Retrieval in Male Posttraumatic Stress Disorder Model Mice

MedComm, Volume 7, Issue 3, March 2026.
PGC‑1α downregulation in hippocampal astrocytes disrupts ATP release and reduces connexin 43 (CX43) expression, impairing neuro‑glial communication. This promotes enhanced fear memory retrieval in PTSD. Chemogenetic activation of astrocytes or PGC‑1α agonist treatment rescues both CX43 expression and fear behavior, identifying astrocytic PGC‑1α/CX43 as
Juan Wang, Xiaoyu Chen, Daokang Chen, Shaojie Yang, Jingji Wang, Ming Chen, Guoqi Zhu   +6 more
wiley   +1 more source