Results 221 to 230 of about 27,021 (267)

Advanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence. [PDF]

Front Reprod Health
Méndez-Vidal C, Fernández-Sánchez M, Domínguez-Moreno M, García-Díaz L, Dopazo J, Antiñolo G.   +5 more
europepmc   +1 more source

Evaluating and Determining the Effects of Psychotropic Drugs on Motor Vehicle Driving Performance: Key Considerations of the Japanese Guideline and Criteria for Clinical Implementation of Evidence

Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
The Japanese guideline and criteria for evaluating and determining the effects of psychotropic drugs on motor vehicle driving performance enable the clinical implementation of evidence by assessing “persistence of clinically meaningful impairment”. ABSTRACT The cross‐national differences in automobile driving precautions stated in psychotropic drug ...
Tetsuo Nakabayashi, Kunihiro Iwamoto, Akiko Yamaguchi, Yuki Konishi, Momoe Saji, Reiji Yoshimura, Kousuke Kanemoto, Hirofumi Aoki, Masahiko Ando, Norio Ozaki   +9 more
wiley   +1 more source

Real-World Data as External Control in Assessing the Efficacy of Allogeneic Adipose-Derived Stem Cells Therapy for Advanced Chronic Kidney Disease. [PDF]

Clin Transl Sci
Lin YC, Hung YP, Tian YC, Wu MJ, Lin HC, Chen SY, Wu MS, Chiou HY.   +7 more
europepmc   +1 more source

From raw data to actionable insights: preprocessing real-world data for machine learning in diabetes care. [PDF]

Front Digit Health
Montagna M, Rabadzhiev AS, Traverso A, Setola E, Draetta E, Dimonte A, Barbieri S, Fabiani B, Piemonti L, Esposito A, Tacchetti C, Rovere Querini P.   +11 more
europepmc   +1 more source

Real-world data and evidence: pioneering frontiers in precision oncology. [PDF]

J Zhejiang Univ Sci B
Jiang J, Pan W, Sun L, Pang L, Chen H, Huang J, Chen W.   +6 more
europepmc   +1 more source

EUROHELICAN—The First Helicobacter Pylori Screen‐and‐Treat Population‐Based Study in Young Adults in Europe

United European Gastroenterology Journal, Volume 14, Issue 2, March 2026.
ABSTRACT Background Most gastric cancer cases are attributable to chronic Helicobacter pylori (H. pylori) infection and can theoretically be prevented. Objective In the EUROHELICAN project, we aimed to assess the feasibility, acceptability, effectiveness, and adverse events of a Helicobacter pylori screen‐and‐treat program in the 30–34‐year age group ...
Bojan Tepeš, Tatjana Kofol Bric, Jernej Završnik, Mitja Oblak, Marcel Kralj, Alja Polajžer, Helena Blažun Vošner, Nataša Maguša Lorber, Jin Young Park, Tamara Matysiak‐Budnik   +9 more
wiley   +1 more source

Enhancing confidence in complex health technology assessments by using real-world evidence: highlighting existing strategies for effective drug evaluation. [PDF]

BMC Med Res Methodol
Antoine A, Desroziers K, Dupin J, Pérol D, Choquet R.   +4 more
europepmc   +1 more source

The Adiponectin‐PP2A Pathway Confers Cognitive Benefits of Physical Exercise Against Chronic Stress‐Induced Tau Hyperphosphorylation in the Hippocampus

Aging Cell, Volume 25, Issue 3, March 2026.
Physical exercise ameliorates cognitive deficits and attenuates Tau hyperphosphorylation under chronic stress by elevating circulating adiponectin levels. Upon receptor binding, adiponectin modulates the LCMT1/PME‐1 regulatory axis to promote PP2A methylation and catalytic function.
Hui‐Hui Guo, Hai‐Ning Ou, Jia‐Sui Yu, Zi‐Rui Luo, Suk‐Yu Yau, Hector Wing‐Hong Tsang   +5 more
wiley   +1 more source

Real-world evidence in metabolic dysfunction-associated steatotic liver disease (MASLD): insights, challenges, and future directions. [PDF]

Lancet Reg Health Eur
Huang HT, Hewitt M, Li W, Alazawi W.
europepmc   +1 more source

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, Volume 36, Issue 2, March 2026.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source