Results 71 to 80 of about 8,452 (228)

Molecular Characterization of Non‐Specific Esophagitis Reveals a Distinct Non‐Eosinophilic Phenotype With Fibrotic Traits

Allergy, EarlyView.
This study comprehensively characterizes non‐specific esophagitis and elucidates eosinophil‐independent fibrosis mechanisms. NSE appears to be a distinct fibrotic phenotype of the esophagus, without any considerable overlap with GERD and other chronic inflammatory disorders such as EoE or lymphocytic esophagitis.
Marc Pfefferle, Darko Stojkov, Dagmar Simon, Emilie Gueguen, Marcin Wawrzyniak, Margaret H. Collins, Mirna Chehade, Evan S. Dellon, Glenn T. Furuta, Ikuo Hirano, Nirmala Gonsalves, Fouad J. Moawad, Luc Biedermann, Alain M. Schoepfer, Alex Straumann, Hans‐Uwe Simon, Thomas Greuter   +16 more
wiley   +1 more source

Remission in Global Airway Diseases: EUFOREA Consensus Paper

Allergy, EarlyView.
ABSTRACT The therapeutic goal in chronic airway diseases is shifting from symptom control to disease remission. Disease‐modifying therapies, including biologics and allergen immunotherapy, have made remission achievable in patients with severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), or allergic rhinitis (AR).
J. Christian Virchow, Xander Bertels, Vibeke Backer, Benjamin S. Bleier, Marco Caminati, Diego M. Conti, Eugenio De Corso, Mina Gaga, Valerie J. Lund, Corrado Pelaia, Anju T. Peters, Glenis K. Scadding, Martin Wagenmann, Riyad O. Al‐Lehebi, Guy G. Brusselle, Philippe Gevaert, Liam G. Heaney, Stella E. Lee, Florence Schleich, Frederik Trinkmann, Peter W. Hellings, Wytske J. Fokkens, Paola Rogliani   +22 more
wiley   +1 more source

RWE in Europe Paper II: The use of Real World Evidence in the disease context [PDF]

, 2017
Real World Evidence (RWE), the use of data not collected via traditional randomised controlled trials (RCT) for decision-making, is becoming more interesting to market-access and reimbursement decision-makers, despite potential methodological issues ...
Gill, Jennifer, Kossler, Ingrid, Thomas, Michael, Spandonaro, Federico, Duncombe, Robert, Wartenberg, Markus, Schramm, Wolfgang, Albanell, Joan, Kanavos, Panos, Fink-Wagner, Antje, Podrazilova, Katerina, Dank, Magdolna, Jahnz-Różyk, Karina, Hutton, John   +13 more
core   +1 more source

Assessing the replicability of RCTs in RWE emulations

BMC Medical Research Methodology
Abstract Background The standard regulatory approach to assess replication success is the two-trials rule, requiring both the original and the replication study to be significant with effect estimates in the same direction.
Köppe, Jeanette, Micheloud, Charlotte, Erdmann, Stella, Heyard, Rachel, Held, Leonhard   +4 more
openaire   +4 more sources

The Increased National Threat of Domestic, Right-Wing Extremist Terrorism

The Journal of Intelligence, Conflict and Warfare, 2018
Right-wing extremism (RWE) presents a national Canadian threat, requiring research and Countering Violent Extremism (CVE) programming, which Canadian security and intelligence is arguably failing to recognize and address.
Caitlin Manz
doaj   +1 more source

Factors for Success and Failure of Allergen Immunotherapy (AIT) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergy, EarlyView.
ABSTRACT Allergen immunotherapy (AIT) has been acknowledged as the only disease‐modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study results may vary substantially.
Roy Gerth van Wijk, Vera Mahler, Melanie Albrecht, Danilo di Bona, Benjamin Hofner, Jasper Kappen, Susanne Kaul, Graham Roberts, Mohamed H. Shamji, Stefan Vieths, Oliver Pfaar   +10 more
wiley   +1 more source

Comparison of two assessments of real‐world data and real‐world evidence for regulatory decision‐making

Clinical and Translational Science
Real‐world data (RWD) and real‐world evidence (RWE) are increasingly used to support regulatory decision making, but regulatory agencies and stakeholders may apply different definitions for RWD and use different criteria to determine when analysis of ...
Lily Yuan, Motiur Rahman, John Concato
doaj   +1 more source

Comparative Real‐World Effectiveness of Anti‐TNF, Ustekinumab and Vedolizumab in Crohn's Disease Over 24 Months: A Pooled Analysis From the Prospective UMBRELLA‐IBD Registry in Germany

Alimentary Pharmacology &Therapeutics, EarlyView.
A pooled analysis from the prospective UMBRELLA‐IBD registry in Germany (n = 1567) showed comparative real‐world effectiveness in treatment persistence and clinical remission of anti‐TNF, Ustekinumab and Vedolizumab in Crohn's disease patients over 24 months.
Arne Bokemeyer, Florian Tran, Sandra Plachta‐Danielzik, Elena Gilman, Thomas Wenske, Matthew Gaskins, Stefan Schreiber, Bernd Bokemeyer   +7 more
wiley   +1 more source

Ultrasonic phased array testing in the power generation industry : novel wedge development for the inspection of steam turbine blades roots [PDF]

The thesis presented herein comprises of the work undertaken to research novel methods of Phased array ultrasonic inspection of complex steam turbine blade roots as found in the power generation industry.
Charlesworth, Chris, Eng.D.
core  

Management analysis of the company RWE Transgas a.s. [PDF]

, 2011
Bakalářská práce se zabývá rozborem výsledků hospodaření společnosti RWE Transgas, a.s. Teoretická část je věnována charakteristice finanční analýzy. Jsou zde vymezeny základní pojmy, metody, ukazatele a hodnotící modely celkové finanční situace podniku.
Fritz, Martin
core