Results 61 to 70 of about 8,310 (238)

Assessing the replicability of RCTs in RWE emulations

BMC Medical Research Methodology
Abstract Background The standard regulatory approach to assess replication success is the two-trials rule, requiring both the original and the replication study to be significant with effect estimates in the same direction.
Köppe, Jeanette, Micheloud, Charlotte, Erdmann, Stella, Heyard, Rachel, Held, Leonhard   +4 more
openaire   +4 more sources

Hallenbeheizung. T. 2 Massnahmen zur Waermerueckgewinnung und zur Nutzung von Umweltwaerme

, 1984
Available from Rheinisch-Westfaelisches Elektrizitaetswerk A.G. (RWE), Essen (DE). Abt.
Rheinisch-Westfaelisches Elektrizitaetswerk A.G. (RWE), Essen (Germany). Abt. Anwendungstechnik, Rittmann, R. (comp.)   +1 more
core  

Time to accelerate rare disease research: AI‐powered in silico trials, digital twin‐driven RCTs and decision‐grade real‐world evidence

British Journal of Clinical Pharmacology, EarlyView.
Andrej Belančić, Elvira Meni Maria Gkrinia, Oscar Della Pasqua, Reecha Sofat, Dinko Vitezić, Robert Likić   +5 more
wiley   +1 more source

Navigating Evidence Standards: Stakeholder Perspectives on External Controls and Randomization in Cancer Trials

Asia-Pacific Journal of Clinical Oncology, EarlyView.
While historically the ‘gold standard,’ the role of large‐scale RCTs is being increasingly challenged in the contemporary oncology research era. External controls represent an alternate method for generating evidence, though the perspectives of key stakeholders regarding their role in oncology are not well known.
Sarah E. Heynemann, Wendy L. Lipworth, Sue‐Anne McLachlan, Jennifer Philip, Tom John, Ian H. Kerridge   +5 more
wiley   +1 more source

R WE ready for reimbursement? A round up of developments in real-world evidence relating to health technology assessment: part 10

Journal of Comparative Effectiveness Research, 2022
In this latest update we discuss the transportability of comparative effectiveness evidence across countries. We highlight results of a survey indicating that European HTA agencies are reluctant to accept real-world data from other countries, review ...
Alex Simpson, Sreeram V Ramagopalan
doaj   +1 more source

Ultrasonic phased array testing in the power generation industry : novel wedge development for the inspection of steam turbine blades roots [PDF]

The thesis presented herein comprises of the work undertaken to research novel methods of Phased array ultrasonic inspection of complex steam turbine blade roots as found in the power generation industry.
Charlesworth, Chris, Eng.D.
core  

Strategic litigation as a challenge for deliberative democracy

American Journal of Political Science, EarlyView.
Abstract Strategic litigation is a growing public concern, but remains understudied in democratic theory. In strategic litigation, collectives go to court with a political agenda that goes beyond their specific case. How should we assess the legitimacy of strategic litigation? Building on Lafont's model of deliberative democracy and Klein's distinction
Svenja Ahlhaus
wiley   +1 more source

RWE in Europe – An Analysis

Journal of Health Policy & Outcomes Research, 2018
Background – This paper outlines findings from four roundtable discussions involving a number of stakeholders. They aimed to improve understanding of the use of real world evidence (RWE) across Europe. They focused on the development of a three-year roadmap for the increased incorporation of RWE, increasingly recognized as a valuable source of ...
openaire   +1 more source

Switching Long‐Term Prophylaxis to Donidalorsen for Hereditary Angioedema: 1‐Year OASISplus Results

Allergy, EarlyView.
This study evaluated the long‐term safety and efficacy of donidalorsen in patients who switched from a long‐term prophylactic treatment (LTP) to donidalorsen with 1‐year outcomes. Patients who switched from LTP to donidalorsen experienced a 67.6% reduction in HAE attack rates over 52 weeks.
Marc A. Riedl, Jonathan A. Bernstein, Joshua S. Jacobs, Timothy Craig, William R. Lumry, H. James Wedner, Aleena Banerji, Selina Gierer, Andrew Smith, Michael E. Manning, Francesca Perego, Laura Bordone, Sabrina Treadwell, Tao Lin, Kenneth B. Newman, Aaron Yarlas, Danny M. Cohn   +16 more
wiley   +1 more source

Red Wine Extract Inhibits VEGF Secretion and Its Signaling Pathway in Retinal ARPE-19 Cells to Potentially Disrupt AMD

Molecules, 2020
Age-related macular degeneration (AMD) is a degenerative disease of the retina where the molecular mechanism involves the production of vascular endothelial growth factor (VEGF), a factor of poor prognosis of the progression of the disease.
Clarisse Cornebise, Flavie Courtaut, Marie Taillandier-Coindard, Josep Valls-Fonayet, Tristan Richard, David Monchaud, Virginie Aires, Dominique Delmas   +7 more
doaj   +1 more source