Results 41 to 50 of about 8,310 (238)

Availability of comparative real-world evidence research in Medicare patients: implications for Centers for Medicare and Medicaid Services drug price negotiations

Journal of Comparative Effectiveness Research, 2023
Aim: To evaluate the availability of published comparative real-world evidence (RWE) studies in Medicare patients for the ten drugs set to undergo Centers for Medicare and Medicaid Services (CMS) price negotiations in 2026.
Ashley Jaksa, Patrick J Arena, Nicolle Gatto   +2 more
doaj   +1 more source

The Role of Transition Intermediaries as Capability Builders for Adopting Radical Innovation in Incumbent Firms: The Case of the UK Energy Supply Sector

Business Strategy and the Environment, EarlyView.
ABSTRACT Transition intermediaries play a pivotal role in configuring networks aligning the interests of stakeholders to achieve sustainable goals. However, the transition literature has paid little attention to the influence intermediaries can have in strengthening organisational capabilities. Especially in sectors that are slow to change, such as the
Horacio Gonzalez, Matthew Hannon, Efstathios Tapinos   +2 more
wiley   +1 more source

The Increased National Threat of Domestic, Right-Wing Extremist Terrorism

The Journal of Intelligence, Conflict and Warfare, 2018
Right-wing extremism (RWE) presents a national Canadian threat, requiring research and Countering Violent Extremism (CVE) programming, which Canadian security and intelligence is arguably failing to recognize and address.
Caitlin Manz
doaj   +1 more source

Real-world evidence for regulatory decision-making: updated guidance from around the world

Frontiers in Medicine, 2023
Leveraging the value of real-world evidence (RWE) to make informed regulatory decisions in the field of health care continues to gain momentum. Improving clinical evidence generation by evaluating the outcomes and patient experiences at the point-of-care
Leah Burns, Nadege Le Roux, Robert Kalesnik-Orszulak, Jennifer Christian, Jennifer Dudinak, Frank Rockhold, Sean Khozin, John O’Donnell   +7 more
doaj   +1 more source

Systematic Evaluation of Data and Trial Fitness for Oncology Trial Emulation: Empirical Findings from the CARE Initiative

Clinical Pharmacology &Therapeutics, EarlyView.
The Coalition to Advance Real‐World Evidence through Randomized Controlled Trial Emulation (CARE) Initiative seeks to advance understanding of when real‐world data (RWD) can generate valid treatment effectiveness estimates by emulating completed oncology randomized controlled trials (RCTs).
Natalie Levy, Paige Sheridan, Ulka Campbell, David Lenis, Inish O'Doherty, Adina Estrin, Nileesa Gautam, Monica Iyer, Sarah McDonald, Andrew Belli, Gillis Carrigan, K. Arnold Chan, James Chen, Victoria Chia, Neil Dhopeshwarkar, Joy Eckert, Laura Fernandes, Joel Greshock, Rachele Hendricks‐Sturrup, Jenny Huang, XiaoLong Jiao, Sajan Khosla, Orsolya Lunacsek, Lynn McRoy, Yanina Natanzon, Osayi Ovbiosa, Nelson Pace, Simone Pinheiro, Megan Rees, Jennifer Rider, Mothaffar Fahed Rimawi, Travis Robinson, Carla Rodriguez‐Watson, Chithra Sangli, Khaled Sarsour, Sebastian Schneeweiss, Mark Shapiro, Mark Stewart, Aliki Taylor, C. K. Wang, Shirley Wang, Yiduo Zhang, Ann Madsen   +42 more
wiley   +1 more source

Real-world evidence in gynecologic cancers presented at key oncology conferences in the United States: Distribution and factors related to high-tier acceptance.

PLoS ONE
PurposeTo describe the distribution, trends, and characteristics of types of real-world evidence (RWE) abstracts presented at key oncology congresses.MethodsData on gynecologic cancers (cervical, ovarian, endometrial, and multiple gynecologic/other) were
Elizabeth A Szamreta, Mansi Modi, Ramu Periyasamy, Bhavani Yamsani, Pattabhi Machiraju, Neetu Menghani, Matthew Monberg   +6 more
doaj   +1 more source

Constructing Policy (In)coherence in Germany's Energy Transition and Impacts on (In)equality

Environmental Policy and Governance, EarlyView.
ABSTRACT Policy coherence is widely regarded as essential for achieving sustainable development, climate targets, and reducing inequality, as reflected in the 2030 Agenda for Sustainable Development. Recent scholarship has moved beyond technocratic approaches, drawing on comparative politics, particularly the “3 I's” of ideas, interests, and ...
Alexia Faus Onbargi, Ines Dombrowsky
wiley   +1 more source

Delayed and deferred surgery associated with cenobamate use in people with drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Cenobamate has been shown to be an effective antiseizure medication for some patients with drug‐resistant focal epilepsy being considered for epilepsy surgery. This retrospective single‐center study evaluated whether surgery was obtained within 12 months for patients who received cenobamate as a treatment during the presurgical ...
Jacob Pellinen, Stefan Sillau, Aimee Bui, Alexandra Danciutiu, Lesley Kaye, Ashvin Sood, Louis Ferrari, William E. Rosenfeld, Christopher Elder   +8 more
wiley   +1 more source

Expression of FcγRIIb in the lungs after RWE challenge.

, 2013
(A) Balb/c mice sensitized with RWE and challenged with either RWE (filled squares) or PBS (open diamond). Mice were sacrificed 1, 4, 24, 72 and 240 h after challenge, lungs were collected and RNA was extracted.
Alexander Kurosky (333545), Istvan Boldogh (16539), Hiroki Murai (333524), Nilesh Dharajiya (333536), Sanjiv A. Sur (366874), Swapnil V. Vaidya (366865), Victor Cardenas (366868)   +6 more
core   +1 more source

Real‐world‐data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris, Elizabeth Mathew, Shalini Bahl, Marta Villa‐Lopez, Saadet Mercimek‐Andrews   +4 more
wiley   +1 more source