Results 101 to 110 of about 2,075 (199)

Contribution of T‐type calcium channel isoforms to cold and mechanical sensitivity in naïve and oxaliplatin‐treated mice of both sexes

British Journal of Pharmacology, Volume 181, Issue 24, Page 5062-5078, December 2024.
Background and Purpose The chemotherapy agent oxaliplatin can give rise to oxaliplatin‐induced peripheral neuropathy (OIPN). Here, we investigated whether T‐type calcium channels (Cav3) contribute to OIPN. Experimental Approach We chronically treated mice with oxaliplatin and assessed pain responses and changes in expression of Cav3.2 calcium channels.
Flavia T. T. Antunes, Maria A. Gandini, Vinicius M. Gadotti, Nara Lins Meira Quintão, José Roberto Santin, Ivana A. Souza, Laurence S. David, Terrance P. Snutch, Michael Hildebrand, Gerald W. Zamponi   +9 more
wiley   +1 more source

Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort [PDF]

, 2016
BACKGROUND: Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. Clinical management of DSD is often difficult and currently only 13% of patients receive an accurate clinical genetic ...
Bergman, P., Bouty, A., Brown, J., Cameron, F., Eggers, S., et al., Grover, S., Heloury, Y., Hewitt, J., Hutson, J., Kimber, C., Knarston, I., Lambeth, L., O'Connell, M., Ohnesorg, T., Robevska, G., Sadedin, S., Tan, T., van den Bergen, J., Werther, G., Zacharin, M.   +20 more
core   +1 more source

Primary Aldosteronism Influences Cardiac Structure, Function, and Disease Risk: Evidence From Mendelian Randomization Analysis

The Journal of Clinical Hypertension, Volume 26, Issue 11, Page 1301-1309, November 2024.
ABSTRACT Although observational studies have linked primary aldosteronism (PA) with cardiovascular diseases (CVDs), the causality remains uncertain. In this study, we aimed to investigate whether PA is causally associated with CVD risk and cardiac magnetic resonance (CMR) parameters using the Mendelian randomization (MR) method.
Rui Shen, Chengliang Pan, Jian Yu, Chen Dong, Zhiyang Li, Jiangmei Zhang, Qian Dong, Kunwu Yu, Qiutang Zeng   +8 more
wiley   +1 more source

Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes. [PDF]

, 2018
The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity.
Cheng, Fang, Guo, Zhifu, Liu, Xinzhu, Ma, Xin-Liang, Sun, Jianxin, Yan, Guijun, Yang, Fan, Yi, Bing, You, Xiaohua, Zhao, Xianxian, Zhu, Ni   +10 more
core   +1 more source

Testicular cancer and cryptorchidism [PDF]

, 2013
The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by ...
Agoulnik, Alexander I., Ferguson, Lydia
core   +2 more sources

Multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints

Molecular Ecology, Volume 33, Issue 20, October 2024.
Abstract The question of how local adaptation takes place remains a fundamental question in evolutionary biology. The variation of allele frequencies in genes under selection over environmental gradients remains mainly theoretical and its empirical assessment would help understanding how adaptation happens over environmental clines.
Badr Benjelloun, Kevin Leempoel, Frédéric Boyer, Sylvie Stucki, Ian Streeter, Pablo Orozco‐terWengel, Florian J. Alberto, Bertrand Servin, Filippo Biscarini, Adriana Alberti, Stefan Engelen, Alessandra Stella, Licia Colli, Eric Coissac, Michael W. Bruford, Paolo Ajmone‐Marsan, Riccardo Negrini, Laura Clarke, Paul Flicek, Abdelkader Chikhi, Stéphane Joost, Pierre Taberlet, François Pompanon   +22 more
wiley   +1 more source

Genome-wide association study for polledness, horn shape, and wool traits in Original Valachian sheep [PDF]

Archives Animal Breeding
The Original Valachian sheep is an endangered Slovak national breed that is well adapted to high-altitude pastures. The sheep can be horned with various shapes and can have multi-coloured or completely white or black wool.
M. Mészárosová, G. Mészáros, N. Moravčíková, I. Pavlík, M. Margetín, R. Kasarda   +5 more
doaj   +1 more source

Recent Advances in Research on the Hormone INSL3 in Male Goats [PDF]

, 2017
Insulin‐like factor 3 (INSL3), previously called relaxin‐like factor (RLF), is essential for testis descent during fetal development and has been implicated in the testicular and sperm functions in adult males.
, Siqin, Kohsaka, Tetsuya, Minagawa, Itaru, Sasada, Hiroshi   +3 more
core   +2 more sources

Testicular seminoma in transverse testicular ectopia

IJU Case Reports, Volume 7, Issue 5, Page 364-367, September 2024.
Introduction Transverse testicular ectopia is a rare anomaly in which both testes descend toward the same side of the hemiscrotum. Case presentation A 35‐year‐old man presented with right inguinal enlargement. Computed tomography showed a normal testis in the right hemiscrotum and a 58 mm heterogeneous mass in the right inguinal area.
Minoru Inoue, Akiyoshi Osaka, Erika Ikezoe, Hiroki Tsujioka, Asumi Nirazuka, Kintaro Hasegawa, Toshiyuki Iwahata, Akinori Nakayama, Kiyoshi Setoguchi, Kazutaka Saito   +9 more
wiley   +1 more source

Importância do estudo multigénico no diagnóstico molecular de doenças raras por sequenciação de nova geração [PDF]

, 2019
Introdução: A sequenciação de nova geração (NGS) revolucionou o diagnóstico molecular das doenças raras (DR) proporcionando a análise de um maior número de genes, resultados mais rápidos e custos reduzidos. A NGS usando diferentes abordagens, possibilita
Gonçalves, João, Oliveira, Beatriz, Pereira Caetano, Iris, Rodrigues, Pedro, Theisen, Patrícia   +4 more
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