Results 111 to 120 of about 1,025 (152)

Whole transcriptome sequencing and ceRNA regulatory network in diabetic peripheral neuropathy. [PDF]

Sci Rep
Yan Q, Zhang M, Xu LJ, Ma J, Wang J, Wang XM, Ma L.   +6 more
europepmc   +1 more source

INSL3/RXFP2 Signaling in Testicular Descent [PDF]

Annals of the New York Academy of Sciences, 2009
Mutations of the insulin-like peptide 3 (INSL3) hormone or its receptor, RXFP2, cause intraabdominal cryptorchidism in male mice. Specific RXFP2 expression in mouse gubernacula was detected at embryonic day 14.5 and markedly increased after birth in the developing cremaster muscle, as well as in the epididymis and testicular Leydig and germ cells ...
Alberto Ferlin, Ross Bathgate, Alexander Agoulnik   +2 more
exaly   +6 more sources

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Modeling the Primary Hormone-Binding Site of RXFP1 and RXFP2

Annals of the New York Academy of Sciences, 2009
The primary binding sites of the relaxin and insulin‐like peptide 3 (INSL3) receptors, RXFP1 and RXFP2, are found within the leucine‐rich repeats (LRRs) of the ectodomains. Specific B‐chain residues in the peptides interact with residues in the inner β‐sheets of the LRRs of the receptors.
Ross Bathgate, Daniel J. Scott, Geoffrey W Tregear   +2 more
exaly   +3 more sources

A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism

Mammalian Genome, 2010
Using genome-wide mutagenesis with N-ethyl-N-nitrosourea (ENU), a mouse mutant with cryptorchidism was identified. Genome mapping and exon sequencing identified a novel missense mutation (D294G) in Relaxin/insulin-like family peptide receptor 2 (Rxfp2).
Ross Bathgate, Alexander Agoulnik, James Jameson   +2 more
exaly   +3 more sources

Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function

Annals of the New York Academy of Sciences, 2009
The receptors for relaxin and insulin‐like peptide 3 (INSL3) are now well‐characterized as the relaxin family peptide (RXFP) receptors RXFP1 and RXFP2, respectively. They are G‐protein‐coupled receptors (GPCRs) with closest similarity to the glycoprotein hormone receptors, with both containing large ectodomains with 10 leucine‐rich repeats (LRRs ...
Ross Bathgate, Daniel J. Scott, Tania Ferraro   +2 more
exaly   +3 more sources

RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis

The FASEB Journal, 2022
Osteoporosis is a chronic bone disease characterized by decreased bone mass and increased risk of developing fractures, predominantly observed in the elderly. Osteoporosis affects approximately 10 million people in the US, and the number is expected to increase exponentially as the elderly population continues to grow.
Maria Esteban‐Lopez, Kenneth Wilson, Courtney Myhr, Elena Kaftanovskaya, Mark Henderson, Noel Southall, Xin Hu, Elena Barnaeva, Marc Ferrer, David Kim, Wenjuan Ye, Roy Morello, Irina Agoulnik, Juan Marugan, Alexander Agoulnik   +14 more
openaire   +1 more source

Mutations in INSL3 and RXFP2 Genes in Cryptorchid Boys

Annals of the New York Academy of Sciences, 2009
Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects.
Riccardo Selice, Alberto Ferlin, Carlo Foresta   +2 more
exaly   +2 more sources

The Importance of Tryptophan B28 in H2 Relaxin for RXFP2 Binding and Activation [PDF]

International Journal of Peptide Research and Therapeutics, 2012
H2 relaxin (relaxin) is a member of the insulin–relaxin superfamily and exhibits several non-reproductive functions in addition to its well-known properties as a pregnancy hormone. Over the years, the therapeutic potential of relaxin has been examined for a number of conditions.
Ross Bathgate, John D Wade, Frances Šeparović   +2 more
exaly   +3 more sources

Discovery of SNPs in RXFP2 related to horn types in sheep

Small Ruminant Research, 2014
Abstract This study was conducted with an attempt to reveal genetic variation in ovine RXFP2 , which is a strong candidate gene that is associated with sheep horn development and types. All 18 exons and intro-exon boundary regions as well as 5′ and 3′ gene flanking regions of RXFP2 were re-sequenced using DNA panels representing four typical horn ...
Xiaolong Wang, Guangxian Zhou, Qiang Li, Dengfei Zhao, Yulin Chen   +4 more
openaire   +1 more source

Mutations in INSL3 and RXFP2 Genes in Cryptorchid Boys

Annals of the New York Academy of Sciences, 2009
Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects.
FERLIN, ALBERTO, ZUCCARELLO D, GAROLLA A, SELICE R, VINANZI C, GANZ F, ZANON GF, ZUCCARELLO B, FORESTA, CARLO   +8 more
openaire   +3 more sources