Results 111 to 120 of about 2,075 (199)

Identification of key residues essential for the structural fold and receptor selectivity within the A-chain of human gene-2 (H2) relaxin [PDF]

, 2012
Human gene-2 (H2) relaxin is currently in Phase III clinical trials for the treatment of acute heart failure. It is a 53-amino acid insulin-like peptide comprising two chains and three disulfide bonds. It interacts with two of the relaxin family peptide (
Akhter Hossain, Bathgate, Bathgate, Bathgate, Brooks, Bryant-Greenwood, Büllesbach, Büllesbach, Büllesbach, Chan, Chen, Du, Hahn, Hartley, Haugaard-Kedström, Heeg, Hewitson, Hossain, Hossain, Hossain, Hossain, Hossain, Hossain, Hsu, Huang, Keller, Kong, Kumagai, Liu, Liu, Park, Rosengren, Rosengren, Samuel, Samuel, Samuel, Samuel, Scott, Scott, Scott, Shabanpoor, Shabanpoor, Sudo, Teerlink, Unemori, Whittaker, Wishart, Wüthrich, Zhang   +48 more
core   +1 more source

Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis

British Journal of Pharmacology, Volume 181, Issue 14, Page 2302-2318, July 2024.
Class A, rhodopsin‐like, G‐protein‐coupled receptors (GPCRs) are by far the largest class of GPCRs and are integral membrane proteins used by various cells to convert extracellular signals into intracellular responses. Initially, class A GPCRs were believed to function as monomers, but a growing body of evidence has emerged to suggest that these ...
Chrishan S. Samuel, Yifang Li, Yan Wang, Robert E. Widdop   +3 more
wiley   +1 more source

In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos

Reproductive Biology and Endocrinology, 2011
Background Relaxin hormone peptide is found in porcine follicular and utero-tubal fluids, but its possible actions during early embryo development are still undetermined.
Willard Scott T, Greene Jonathan M, Feugang Jean M, Ryan Peter L   +3 more
doaj   +1 more source

Discovery of First-in-Class Small Molecule Agonists of the RXFP2 Receptor as Therapeutic Candidates for Osteoporosis [PDF]

, 2022
Osteoporosis is a chronic bone disease characterized by decreased bone mass and increased risk of developing fractures, predominantly observed in the elderly.
Esteban Lopez, Maria
core   +1 more source

Targeting G protein‐coupled receptors for heart failure treatment

British Journal of Pharmacology, Volume 181, Issue 14, Page 2270-2286, July 2024.
Heart failure remains a leading cause of morbidity and mortality worldwide. Current treatment for patients with heart failure include drugs targeting G protein‐coupled receptors such as β‐adrenoceptor antagonists (β‐blockers) and angiotensin II type 1 receptor antagonists (or angiotensin II receptor blockers).
Bui San Thai, Ling Yeong Chia, Anh T. N. Nguyen, Chengxue Qin, Rebecca H. Ritchie, Dana S. Hutchinson, Andrew Kompa, Paul J. White, Lauren T. May   +8 more
wiley   +1 more source

Genomic prediction of the polled and horned phenotypes in Merino sheep

Genetics Selection Evolution, 2018
Background In horned sheep breeds, breeding for polledness has been of interest for decades. The objective of this study was to improve prediction of the horned and polled phenotypes using horn scores classified as polled, scurs, knobs or horns.
Naomi Duijvesteijn, Sunduimijid Bolormaa, Hans D. Daetwyler, Julius H. J. van der Werf   +3 more
doaj   +1 more source

Ovarian Expression of Insulin-Like Peptide 3 (INSL3) and Its Receptor (RXFP2) During Development of Bovine Antral Follicles and Corpora Lutea and Measurement of Circulating INSL3 Levels During Synchronized Estrous Cycles [PDF]

, 2013
Leanne Satchell, Claire Glister, E.C.L. Bleach, Richard G. Glencross, Andrew B. Bicknell, Yanzhenzi Dai, Ravinder Anand‐Ivell, Richard Ivell, P. G. Knight   +8 more
openalex   +1 more source

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

iScience, 2019
Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism.
Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate   +8 more
doaj   +1 more source

MOESM1 of The 1.78-kb insertion in the 3′-untranslated region of RXFP2 does not segregate with horn status in sheep breeds with variable horn status

, 2016
Gesine Lühken, Stefan Krebs, Sophie Rothammer, Julia Küpper, Boro Mioč, Ingolf Russ, Ivica Medugorac   +6 more
openalex   +2 more sources

Whole-genome sequences of 89 Chinese sheep suggest role of RXFP2 in the development of unique horn phenotype as response to semi-feralization [PDF]

, 2018
Zhangyuan Pan, Shengdi Li, Qiuyue Liu, Zhen Wang, Zhengkui Zhou, Ran Di, Benpeng Miao, Wenping Hu, Xiangyu Wang, Xiaoxiang Hu, Ze Xu, Dongkai Wei, Xiaoyun He, Liyun Yuan, Xiaofei Guo, Benmeng Liang, Ruichao Wang, Xiaoyu Li, Xiaohan Cao, Xinlong Dong, Qing Xia, Hongcai Shi, Geng Hao, Jean Yang, Cuicheng Luosang, Yiqiang Zhao, Mei Jin, Yingjie Zhang, Shenjin Lv, Fukuan Li, Guohui Ding, Mingxing Chu, Yixue Li   +32 more
openalex   +1 more source