Results 171 to 180 of about 2,075 (199)

RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis

The FASEB Journal, 2022
Osteoporosis is a chronic bone disease characterized by decreased bone mass and increased risk of developing fractures, predominantly observed in the elderly. Osteoporosis affects approximately 10 million people in the US, and the number is expected to increase exponentially as the elderly population continues to grow.
Maria Esteban‐Lopez, Kenneth Wilson, Courtney Myhr, Elena Kaftanovskaya, Mark Henderson, Noel Southall, Xin Hu, Elena Barnaeva, Marc Ferrer, David Kim, Wenjuan Ye, Roy Morello, Irina Agoulnik, Juan Marugan, Alexander Agoulnik   +14 more
openaire   +1 more source

Discovery of SNPs in RXFP2 related to horn types in sheep

Small Ruminant Research, 2014
Abstract This study was conducted with an attempt to reveal genetic variation in ovine RXFP2 , which is a strong candidate gene that is associated with sheep horn development and types. All 18 exons and intro-exon boundary regions as well as 5′ and 3′ gene flanking regions of RXFP2 were re-sequenced using DNA panels representing four typical horn ...
Xiaolong Wang
exaly   +2 more sources

Mutations in INSL3 and RXFP2 Genes in Cryptorchid Boys

Annals of the New York Academy of Sciences, 2009
Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects.
Alberto Ferlin, Andrea Garolla, Carlo Foresta   +2 more
exaly   +2 more sources

The Insulin-Like Factor 3 (INSL3)-Receptor (RXFP2) Network Functions as a Germ Cell Survival/Anti-Apoptotic Factor in Boar Testes [PDF]

Endocrinology, 2015
Enock Y Park, Tetsuya Kohsaka
exaly   +2 more sources

Mutations in INSL3 and RXFP2 Genes in Cryptorchid Boys

Annals of the New York Academy of Sciences, 2009
Mutations in the INSL3 and RXFP2 genes have been associated with human cryptorchidism but with contrasting data. We analyzed the frequency of mutations in these genes in 600 newborns with cryptorchidism (396 unilateral and 204 bilateral) and 300 noncryptorchid subjects.
FERLIN, ALBERTO, ZUCCARELLO D, GAROLLA A, SELICE R, VINANZI C, GANZ F, ZANON GF, ZUCCARELLO B, FORESTA, CARLO   +8 more
openaire   +3 more sources

Biallelic RXFP2 variants lead to congenital bilateral cryptorchidism and male infertility, supporting a role of RXFP2 in spermatogenesis

Human Reproduction
Abstract STUDY QUESTION Does RXFP2 disruption impair male fertility? SUMMARY ANSWER We identified biallelic variants in RXFP2 in patients with male infertility due to spermatogenic arrest at the spermatid stage, supporting a role of ...
Hannes Syryn, Julie Van de Velde, Griet De Clercq, Hannah Verdin, Annelies Dheedene, Frank Peelman, Andrew Sinclair, Katie L Ayers, Ross A D Bathgate, Martine Cools, Elfride De Baere   +10 more
openaire   +2 more sources

Regulation of Rxfp2 (Lgr8) Expression in the Mouse Fetal Kidney by the Transcription Factor Pod1 (Tcf 21)

Annals of the New York Academy of Sciences, 2009
Rxfp2 is present in putative mesangial cells at embryonic stage 18 (E18) in the rat kidney, suggesting that insulin‐like peptide 3 is involved in glomerulogenesis. One of the main regulatory factors in glomerulogenesis is the basic helix‐loop‐helix transcription factor Pod1.
Mary Familari, Laura Jean Parry
exaly   +3 more sources

Expression pattern of zebrafish rxfp2 homologue genes during embryonic development

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2015
ABSTRACTRXFP2 is one of the 4 receptors for relaxin insulin‐like peptides, in particular it binds with high affinity the INSL3 peptide. INSL3/RXFP2 pair is essential for testicular descent during placental mammalian development. The evolutionary history of this ligand/receptor pair has received much attention, since its function in vertebrate species ...
DONIZETTI, ALDO, Fiengo, M, DEL GAUDIO, ROSANNA, IAZZETTI, GIOVANNI, Pariante, P, Minucci, S, ANIELLO, FRANCESCO   +6 more
openaire   +4 more sources

An insight into testis and gubernaculum dynamics of INSL3–RXFP2 signalling during testicular descent in the dog

Reproduction, Fertility and Development, 2010
Insulin-like 3 (INSL3) plays a prominent role in male development and is supposed to induce the growth of the gubernaculum testis (g.t.), thus being directly involved in testicular descent in humans and rodents. This happens through activation of the RXFP2 receptor (GREAT or LGR8). The INSL3–RXFP2 complex is reputed to play an additional paracrine role
Arrighi S., Bosi G., Groppetti D., Aralla M., Cremonesi F.   +4 more
openaire   +2 more sources

Relaxin Family Peptide Receptors RXFP1 and RXFP2 Modulate cAMP Signaling by Distinct Mechanisms

Molecular Pharmacology, 2006
Two orphan leucine-rich repeat-containing G protein-coupled receptors were recently identified as targets for the relaxin family peptides relaxin and insulin-like peptide (INSL) 3. Human gene 2 relaxin is the cognate ligand for relaxin family peptide receptor (RXFP) 1, whereas INSL3 is the ligand for RXFP2.
Michelle L, Halls, Ross A D, Bathgate, Roger J, Summers   +2 more
openaire   +2 more sources