Rxfp2 - Open Access .click

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Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of β-arrestin recruitment

American Journal of Physiology-Cell Physiology, 2009
Relaxin induces sustained physiological responses, which brings into question the deactivation processes typical of most G protein-coupled receptors (GPCR) for its receptor, relaxin family peptide receptor 1 (RXFP1). Here, we examined relaxin-dependent phosphorylation of RXFP1 and the related insulin-like peptide 3 (INSL3) receptor, RXFP2, as well as ...
Callander, Gabrielle E. +2 more
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Expression and localization of RLF/ INSL3 receptor RXFP2 in boar testes

IJAE : Italian Journal of Anatomy and Embryology : 118, 1 Supplement, 2013
This study investigated the possibility of the presence of specific receptor for relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) in boar testes. While RLF/INSL3 was produced by Leydig cells in the boar testis, its own receptor RXFP2 was expressed mainly in meiotic and post-meiotic germ cells, but not in Leydig cells, suggesting the existence ...
Kohsaka, Tetsuya +4 more
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Genetic Association of RXFP2 T222P Variant With Cryptorchidism: A Meta‐Analytic Study

Andrology
ABSTRACT Background The RXFP2 receptor plays a key role in testicular descent, mediating the action of relaxin on gubernaculum development. The T222P polymorphism in the RXFP2 gene has previously been investigated in relation to
Jacek Kabziński, Jerzy Niedzielski, Ireneusz Majsterek +2 more
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Constitutive activity of human RXFP2