Results 101 to 110 of about 2,365,951 (330)

Phosphorylation of Ryanodine Receptors

Biological Research, 2004
Both cardiac and skeletal muscle ryanodine receptors (RyRs) are parts of large complexes that include a number of kinases and phosphatases. These RyRs have several potential phosphorylation sites in their cytoplasmic domains, but the functional consequences of phosphorylation and the identity of the enzymes responsible have been subjects of ...
DANILA, CRISTINA I, HAMILTON, SUSAN L
openaire   +4 more sources

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

Channels, 2014
Dysregulated endoplasmic reticulum (ER) calcium (Ca2+) signaling is reported to play an important role in Alzheimer disease (AD) pathogenesis. The role of ER Ca2+ release channels, the ryanodine receptors (RyanRs), has been extensively studied in AD ...
Jie Liu, C. Supnet, Suya Sun, Hua Zhang, L. Good, E. Popugaeva, I. Bezprozvanny   +6 more
semanticscholar   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

A Mechanism for Statin-Induced Susceptibility to Myopathy

JACC: Basic to Translational Science, 2019
Summary: This study aimed to identify a mechanism for statin-induced myopathy that explains its prevalence and selectivity for skeletal muscle, and to understand its interaction with moderate exercise.
Sabine Lotteau, PhD, Niklas Ivarsson, PhD, Zhaokang Yang, PhD, Damien Restagno, PhD, John Colyer, PhD, Philip Hopkins, MD, Andrew Weightman, PhD, Koichi Himori, MSc, Takashi Yamada, PhD, Joseph Bruton, PhD, Derek Steele, PhD, Håkan Westerblad, MD, PhD, Sarah Calaghan, PhD   +12 more
doaj   +1 more source

Modeling effects of L-type ca(2+) current and na(+)-ca(2+) exchanger on ca(2+) trigger flux in rabbit myocytes with realistic T-tubule geometries. [PDF]

, 2012
The transverse tubular system of rabbit ventricular myocytes consists of cell membrane invaginations (t-tubules) that are essential for efficient cardiac excitation-contraction coupling. In this study, we investigate how t-tubule micro-anatomy, L-type Ca(
Andrew D McCulloch, Anushka Plamenova Michailova, Frank B Sachse, Frank B Sachse, J Andrew eMcCammon, Johan E Hake, Johan E Hake, John H Bridge, Michael J Holst, Peter M Kekenes-Huskey, Yuhui eCheng   +10 more
core   +2 more sources

Perioperative management of malignant hyperthermia during general anesthesia: A report of two cases

Clinical Case Reports, 2022
Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality.
Xiaowei Chi, Yi Xu, Hongbing Liao, Tao Chen, Qiang Li, Qiang Fu   +5 more
doaj   +1 more source

Transcriptomic Remodeling of Pulmonary Vein Sleeves Suggests a Role in Atrial Arrhythmogenesis in Thoroughbred Horses

Annals of the New York Academy of Sciences, EarlyView.
Myocardial sleeves of the pulmonary veins in racehorses with paroxysmal atrial fibrillation exhibit upregulated pathways associated with tissue structure remodeling. Pathways related to the extracellular matrix and cellular components differ significantly from those in healthy horses.
Magdalena Arevalo‐Turrubiarte, Charlotte E. Edling, Carla Moller‐Levet, Bronte Forbes, Victoria Kemp, Joe Weir, Celia Marr, Rebecca Lewis, Kamalan Jeevaratnam   +8 more
wiley   +1 more source

A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer’s Disease Mouse Models by Upregulating Neuronal Autophagy [PDF]

, 2023
Hua Zhang, Caitlynn Knight, Shaozong Chen, Ilya Bezprozvanny   +3 more
openalex   +1 more source

Molecular genetic analysis for malignant hyperthermia : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry [PDF]

, 2004
Malignant hyperthermia (MH) is a rare pharmacogenetic disorder in humans caused by inhalational general anaesthetics and depolarising muscle relaxants. An MH reaction shows abnormal calcium homeostasis in skeletal muscle leading to a hypermetabolic state
Sato, Keisaku
core  

Systolic‐dominant coronary flow in rats and mice: Challenging the diastolic paradigm across conscious and anaesthetized states

Experimental Physiology, EarlyView.
Abstract Extensive research in humans, dogs, rabbits, rats, mice and other mammals has consistently demonstrated that coronary blood flow (CBF) peaks during ventricular diastole. For example, studies using transthoracic Doppler echocardiography in anaesthetized rats and mice, isolated blood‐perfused rat hearts and Doppler probes sutured to the ...
Heidi L. Lujan, Theodore W. Kurtz, Stephen E. DiCarlo   +2 more
wiley   +1 more source