Results 141 to 150 of about 2,365,951 (330)

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator [PDF]

, 2001
Angela F. Dulhunty, Peter W. Gage, Suzanne M. Curtis, Gareth Chelvanayagam, Philip G. Board   +4 more
openalex   +1 more source

Epigenetic changes as a common trigger of muscle weakness in congenital myopathies [PDF]

, 2017
Congenital myopathies are genetically and clinically heterogeneous conditions causing severe muscle weakness, and mutations in the ryanodine receptor gene (RYR1) represent the most frequent cause of these conditions.
Attali, Ruben, Finotti, Alessia, Gambari, Roberto, Gautel, Mathias, Heytens, Luc, Jungbluth, Heinz, Mitrani-Rosenbaum, Stella, Mosca, Barbara, Muntoni, Francesco, Nevo, Yoram, Pillay, Komala, Rokach, Ori, Sekulic-Jablanovic, Marijana, Treves, Susan, Voermans, Nicol, Wilmshurst, Jo, Zhou, Haiyan, Zorzato, Francesco   +17 more
core  

Dantrolene Sodium Can Increase or Attenuate Activity of Skeletal Muscle Ryanodine Receptor Calcium Release Channel [PDF]

, 1996
Thomas E. Nelson, Marina Lin, Gisele Zapata‐Sudo, Roberto T. Sudo   +3 more
openalex   +1 more source

A model of β‐adrenergic stimulation in human ventricular cells for tissue‐scale simulations of sympathetically modulated tachycardias

The Journal of Physiology, EarlyView.
Abstract figure legend Modelling β‐adrenergic stimulation in sympathetically remodelled ventricular substrates. Myocardial infarction could result in sympathetic remodelling in ventricular tissues, which affects arrhythmia dynamics. However sympathetic remodelling is challenging to control experimentally; therefore we created an ionic model that ...
Kelly Zhang, Karl Magtibay, Natalia Trayanova, Edward Vigmond   +3 more
wiley   +1 more source

Data_Sheet_1_Modulation of Ryanodine Receptors Activity Alters the Course of Experimental Autoimmune Encephalomyelitis in Mice.docx

, 2021
Natalia C. Osipchuk (11849477), Athena M. Soulika (9576827), Alla F. Fomina (11849480)   +2 more
openalex   +2 more sources

Ryanodine receptor leak triggers fiber Ca ²⁺ redistribution to preserve force and elevate basal metabolism in skeletal muscle [PDF]

, 2021
C. R. Lamboley, Luke Pearce, Crystal Seng, Aldo Meizoso‐Huesca, Daniel P. Singh, Barnaby P. Frankish, Vikas Kaura, Harriet P. Lo, Charles Ferguson, Paul D. Allen, Philip M. Hopkins, Robert G. Parton, Robyn M. Murphy, Chris van der Poel, C. J. Barclay, Bradley S. Launikonis   +15 more
openalex   +1 more source

Overshoot in biological systems modeled by Markov chains: a nonequilibrium dynamic phenomenon

, 2014
A number of biological systems can be modeled by Markov chains. Recently, there has been an increasing concern about when biological systems modeled by Markov chains will perform a dynamic phenomenon called overshoot.
Jia, Chen, Jiang, Daquan, Qian, Minping
core   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Ryanodine receptors are part of the myospryn complex in cardiac muscle

Scientific Reports, 2017
The Cardiomyopathy–associated gene 5 (Cmya5) encodes myospryn, a large tripartite motif (TRIM)-related protein found predominantly in cardiac and skeletal muscle. Cmya5 is an expression biomarker for a number of diseases affecting striated muscle and may
Matthew A. Benson, Caroline L. Tinsley, Adrian J. Waite, Francesca A. Carlisle, Steve M. M. Sweet, Elisabeth Ehler, Christopher H. George, F. Anthony Lai, Enca Martin-Rendon, Derek J. Blake   +9 more
doaj   +1 more source