Results 61 to 70 of about 2,365,951 (330)

Marked Sexual Dimorphism in the Role of the Ryanodine Receptor in a Model of Pain Chronification in the Rat

Scientific Reports, 2016
Hyperalgesic priming, an estrogen dependent model of the transition to chronic pain, produced by agonists at receptors that activate protein kinase C epsilon (PKCε), occurs in male but not in female rats.
L. Ferrari, E. Khomula, Dionéia Araldi, J. Levine   +3 more
semanticscholar   +1 more source

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling

iScience, 2020
Summary: This study shows that multiple modes of mitochondrial stress generated by partial mtDNA depletion or cytochrome c oxidase disruption cause ryanodine receptor channel (RyR) dysregulation, which instigates the release of Ca2+ in the cytoplasm of ...
Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, Narayan G. Avadhani   +4 more
doaj   +1 more source

Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure [PDF]

, 2018
Aims: Cellular processes in the heart rely mainly on studies from experimental animal models or explanted hearts from patients with terminal end-stage heart failure (HF).
Condorelli, Gianluigi, Contu, Riccardo, Ellingsen, Øyvind, Haaverstad, Rune, Høydal, Morten Andre, Karevold, Asbjørn, Kemi, Ole J., Kirkeby-Garstad, Idar, Smith, Godfrey L., Stølen, Tomas L., Wahba, Alexander, Wiseth, Rune, Wisløff, Ulrik   +12 more
core   +2 more sources

Kinetics and mapping of Ca-driven calmodulin conformations on skeletal and cardiac muscle ryanodine receptors

Nature Communications
Calmodulin transduces [Ca2+] information regulating the rhythmic Ca2+ cycling between the sarcoplasmic reticulum and cytoplasm during contraction and relaxation in cardiac and skeletal muscle.
Robyn T. Rebbeck, Bengt Svensson, Jingyan Zhang, Montserrat Samsó, David D. Thomas, Donald M. Bers, Razvan L. Cornea   +6 more
doaj   +1 more source

Pathophysiological Role of Caveolae in Hypertension [PDF]

, 2019
Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver, Gollasch, Maik, Kaßmann, Mario, Lian, Xiaoming, Matthaeus, Claudia   +4 more
core   +2 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons.

PLoS ONE, 2020
The slow afterhyperpolarising current, sIAHP, is a Ca2+-dependent current that plays an important role in the late phase of spike frequency adaptation.
Angelo Tedoldi, Petra Ludwig, Gianluca Fulgenzi, Hiroshi Takeshima, Paola Pedarzani, Martin Stocker   +5 more
doaj   +1 more source

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

Proceedings of the National Academy of Sciences of the United States of America, 2015
Significance Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic syndrome characterized by life-threatening cardiac arrhythmias triggered by physical exercise or emotional stress.
Yan Ting Zhao, C. Valdivia, Georgina B. Gurrola, Georgina B. Gurrola, Patricia P. Powers, B. C. Willis, R. Moss, J. Jalife, H. Valdivia   +8 more
semanticscholar   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

A "synaptoplasmic cistern" mediates rapid inhibition of cochlear hair cells [PDF]

, 2004
Cochlear hair cells are inhibited by cholinergic efferent neurons. The acetylcholine (ACh) receptor of the hair cell is a ligand-gated cation channel through which calcium enters to activate potassium channels and hyperpolarize the cell.
Fuchs, Paul A., Glowatzki, Elisabeth, Hiel, Hakim, Katz, Eleonora, Kong, Jee-Hyun, Lioudyno, Maria, Parameshwaran Iyer, Suchitra, Waldman, Erik   +7 more
core   +1 more source