Results 51 to 60 of about 15,708 (115)
S-Nitrosylation: An Emerging Paradigm of Redox Signaling
Antioxidants, 2019 Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple human diseases, including cancer.
Veani Fernando +5 more
doaj +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 43, 3 August 2026.Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu +9 more
wiley +1 more source
Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases
Neurobiology of Disease, 2015 Nitric oxide (NO) is a gasotransmitter that impacts fundamental aspects of neuronal function in large measure through S-nitrosylation, a redox reaction that occurs on regulatory cysteine thiol groups.
Tomohiro Nakamura +9 more
doaj +1 more source
Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review
eFood, Volume 7, Issue 4, August 2026.Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu +11 more
wiley +1 more source
Identification of new targets of S-nitrosylation in neural stem cells by thiol redox proteomics
Redox Biology, 2020 Nitric oxide (NO) is well established as a regulator of neurogenesis. NO increases the proliferation of neural stem cells (NSC), and is essential for hippocampal injury-induced neurogenesis following an excitotoxic lesion.
Ana Isabel Santos +12 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira +3 more
wiley +1 more source
MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities
Cancer Science, Volume 117, Issue 8, Page 2050-2063, August 2026.Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah +3 more
wiley +1 more source
The Effect of Chlorhexidine Mouthwash on Blood Pressure: A Systematic Review and Meta‐Analysis
International Journal of Dental Hygiene, Volume 24, Issue 3, Page 390-403, August 2026.ABSTRACT Aim This study evaluated the effect of rinsing with a chlorhexidine containing mouthwash (CHX‐MW) on blood pressure (BP), as compared to rinsing with a control MW or no MW, based on (randomised) controlled trials and observational studies in humans. PROSPERO CRD42020222495.
Lars S. J. Toonen +5 more
wiley +1 more source