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Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the S-acylation machinery. [PDF]

open access: yesChem Sci
Busquets-Hernández C   +7 more
europepmc   +1 more source

Using hydroxylamines for the study of S-acylation

open access: yes, 2023
Triola Guillem, Gemma   +4 more
openaire   +1 more source
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S-Acylation of Proteins

2019
Palmitoylation or S-acylation is the posttranslational attachment of fatty acids to cysteine residues and is common among integral and peripheral membrane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect, and vertebrate cells), as well as in viruses grown in these cells.
Larisa, Kordyukova   +3 more
openaire   +2 more sources

S-acylation by the DHHC protein family

Biochemical Society Transactions, 2010
A family of 23 DHHC (Asp-His-His-Cys) proteins that function as mammalian S-acyltransferases has been identified, reinvigorating the study of protein S-acylation. Recent studies have continued to reveal how S-acylation affects target proteins, and have provided glimpses of how DHHC-substrate specificity might be achieved.
Greaves, Jennifer, Chamberlain, Luke H
openaire   +3 more sources

Location, location, S-acylation

Science, 2016
Plant Science![Figure][1] The stems of cellulose-deficient plants display collapsing xylem (blue). PHOTO: SIMON TURNER Cellulose synthase is a large, multisubunit machine that “swims” along the plant cell membrane as it spins out cellulose fibers. Kumar et al.
openaire   +1 more source

Protein S-Acylation in Pulmonary Disease

Free Radical Biology and Medicine, 2016
Obesity is a major risk factor for asthma. Obese asthmatics exhibit poor symptom control, frequent exacerbation, and increased levels of reactive oxygen species (ROS). The consumption of a western diet, high in fat and carbohydrates, can both induce obesity and increase ROS.
Matthew J Randall   +4 more
openaire   +1 more source

Analysis of S-Acylation of Proteins

2003
Palmitoylation or S-acylation is the post-translational attachment of fatty acids to cysteine residues and is common among integral and peripheral mem brane proteins. Palmitoylated proteins have been found in every eukaryotic cell type examined (yeast, insect, and vertebrate cells), as well as in viruses grown in these cells.
Michael, Veit   +2 more
openaire   +3 more sources

Protein S-acylation in plants (Review)

Molecular Membrane Biology, 2009
Membrane resident proteins are a common feature of biology yet many of these proteins are not integral to the membrane. These peripheral membrane proteins are often bound to the membrane by the addition of fatty acyl chains to the protein. This modification, known as S-acylation or palmitoylation, promotes very strong membrane association but is also ...
openaire   +3 more sources

Assaying Protein S-Acylation in Plants

2013
S-acylation is increasingly being recognized as an important posttranslational modification of proteins controlling activity, subcellular localization, microdomain residence, and stability. Heterotrimeric G-proteins and GPCRs are particularly well studied S-acylated proteins, and fast, cheap, reliable methods are required for the analysis of S ...
openaire   +3 more sources

Direct Analysis of Protein S-Acylation by Mass Spectrometry

2019
Dynamic and reversible protein S-acylation, most commonly occurring as S-palmitoylation, plays an important role in protein/membrane association and the regulation of intracellular signaling via cycles of palmitoylation and depalmitoylation. Direct analysis of protein S-acylation by mass spectrometry (MS) offers several benefits over indirect detection
Yuhuan, Ji, Cheng, Lin
openaire   +2 more sources

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