Results 101 to 110 of about 21,334,376 (275)

Decoding a Gut Commensal Signal: Structural and Immunological Profiling of Segatella Copri Lipopolysaccharide

Angewandte Chemie, EarlyView.
The lipopolysaccharide (LPS) of Segatella copri is a structurally unique, immunomodulatory glycoconjugate. Combining mass spectrometry (MS), nuclear magnetic resonance (NMR), and cytometry by time‐of‐flight (CyTOF), we uncover a rough‐type LPS with reduced TLR4 agonism and selective monocyte effects, further highlighting the key role of LPS chemistry ...
Luca De Simone Carone, Giusi Barra, Roberta Cirella, Marcello Ziaco, Marcello Mercogliano, Francesca Olmeo, Emanuela Andretta, Valentina Mazziotti, Carmela Fusco, Giuliana D'Ippolito, Katarzyna Anna Duda, Freda M. Farquharson, Petra Louis, Angelo Fontana, Alba Silipo, Antonio Molinaro, Fabrizio Chiodo, Flaviana Di Lorenzo   +17 more
wiley   +2 more sources

Fatty acid acylation of proteins: specific roles for palmitic, myristic and caprylic acids

Oilseeds and fats, crops and lipids, 2016
Fatty acid acylation of proteins corresponds to the co- or post-translational covalent linkage of an acyl-CoA, derived from a fatty acid, to an amino-acid residue of the substrate protein.
Rioux Vincent
doaj   +1 more source

Proteomic analysis of a poplar cell suspension culture suggests a major role of protein S-acylation in diverse cellular processes

Frontiers in Plant Science, 2016
S-acylation is a reversible post-translational modification (PTM) of proteins known to be involved in membrane targeting, subcellular trafficking and the determination of a great variety of functional properties of proteins.
Vaibhav eSrivastava, Joseph R. Weber, Erik eMalm, Bruce William Fouke, Vincent eBulone, Vincent eBulone   +5 more
doaj   +1 more source

S-acylation of CBL10/SCaBP8 by PAT10 is crucial for its tonoplast association and function in salt tolerance.

Journal of Integrative Plant Biology, 2020
Protein S-acylation is a reversible post-translational modification that involves the addition of a 16-carbon saturated lipid group, usually a palmitate group, to cysteine residues of a substrate protein (Hemsley and Grierson 2008; Hemsley et al.
Sen Chai, Fu-Rong Ge, Yan Zhang, Sha Li
semanticscholar   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Synthesis and Application of Bioactive N‐Functionalized Aziridines

Angewandte Chemie, EarlyView.
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan, Samya Samanta, Nan Qiu, Alexander Adibekian, David C. Powers   +4 more
wiley   +2 more sources

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Bioinformatics and Expression Profiling of the DHHC-CRD S-Acyltransferases Reveal Their Roles in Growth and Stress Response in Woodland Strawberry (Fragaria vesca)

Plants
Protein S-acyl transferases (PATs) are a family of enzymes that catalyze protein S-acylation, a post-translational lipid modification involved in protein membrane targeting, trafficking, stability, and protein–protein interaction.
Si Gu, Xinghua Nie, Amal George, Kyle Tyler, Yu Xing, Ling Qin, Baoxiu Qi   +6 more
doaj   +1 more source

Global, site-specific analysis of neuronal protein S-acylation

Scientific Reports, 2017
Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins, Keith T. Woodley, Jyoti S. Choudhary   +2 more
doaj   +1 more source

The Role of S-Acylation in the Regulation of Store-Operated Calcium Entry [PDF]

, 2021
Savannah J. West, Qiaochu Wang, Goutham Kodakandla, Michael X. Zhu, Darren Boehning, Askar M. Akimzhanov   +5 more
openalex   +1 more source