Results 111 to 120 of about 37,335 (238)

University teaching of mass spectrometry as a key practical technique within the context of a fully integrated, spiral curriculum

Rapid Communications in Mass Spectrometry, EarlyView.
Rationale Mass spectrometry (MS) is introduced to high school students in the UK in many pre‐university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their studies.
Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart   +3 more
wiley   +1 more source

Refining S-acylation: Structure, regulation, dynamics, and therapeutic implications. [PDF]

J Cell Biol, 2023
Anwar MU, van der Goot FG.
europepmc   +1 more source

The S-acylation switch in activated T cells [PDF]

S-acylation is a reversible post-translational modification involving the covalent attachment of a fatty acid to a cysteine residue of a protein. This modification can influence protein conformation, localization, and protein-protein interactions. Due to its reversibility, S-acylation functions as a regulatory switch in various cellular processes ...
openaire   +1 more source

Porous Organic Polymers: From Molecular Design to Scalable Technologies

Small, EarlyView.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem, Hadi Shayesteh, Simindokht Zarei‐Shokat, Rokhsareh Bakhtiari, Sheyda Abedi‐Banaei, Zahra Sheikhlouiharzand, Parnia Mohebimanesh, Seyed Mohammad Amin Ojagh, Bahareh Bakhtiari, Ali Maleki, Theo G. M. van de Ven, Sohrab Zendehboudi, Ali Elkamel   +12 more
wiley   +1 more source

Triplet Energy Transfer Strategy for Visible Light Activation of Bio‐Based Oxime Esters in Photopolymerization and 3D Printing

Small, EarlyView.
Bio‐based oxime esters are converted into efficient metal‐free photoinitiators for 405 nm LEDs and sunlight by Dexter‑type triplet energy transfer from ITX, enabling fast and deep visible light curing, high‐resolution 3D printing and improved cytocompatibility.
Kaidan Yang, Céline Dietlin, Coralie Ohl, Margot Manivel, Fabrice Morlet‐Savary, Michael Schmitt, Gérard Audran, Jean‐Patrick Joly, Jing Zhang, Pu Xiao, Jacques Lalevée   +10 more
wiley   +1 more source

Redox‐responsive dual‐drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance

Smart Molecules, EarlyView.
This study presents a novel glutathione‐activatable prodrug nanomedicine (cRGD‐PEG‐PGlu‐NP (ssTrypsin & CDDP)) that co‐encapsulates cisplatin and a masked protease to combat cisplatin resistance. The dual‐drug system selectively targets resistant tumor cells, enhancing the efficacy of cisplatin while minimizing systemic toxicity.
Xiaolan Yin, Qi Wang, Ming Zhang, Cheng Zhang, Qixian Chen, Haidong Li, Yan Zhao, Yue Wang, Jingyun Wang, Liuwei Zhang, Hongyan Cui   +10 more
wiley   +1 more source

S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. [PDF]

Mol Cell, 2023
Huang X, Yao J, Liu L, Chen J, Mei L, Huangfu J, Luo D, Wang X, Lin C, Chen X, Yang Y, Ouyang S, Wei F, Wang Z, Zhang S, Xiang T, Neculai D, Sun Q, Kong E, Tate EW, Yang A.   +20 more
europepmc   +1 more source

Smart cellulose‐based room temperature phosphorescent materials: From mechanisms to construction strategies and applications

Smart Molecules, EarlyView.
This review elucidates the photophysical mechanisms of cellulose‐based room temperature phosphorescent materials and systematically outlines their construction strategies, such as cluster emission center engineering. This article demonstrates their applications in fields like information encryption and bioimaging, and looks ahead to the core challenges
Shasha Wu, Yifan Zhou, Wanjin Wu, Yan Tang, Mengfan Jing, Jianyu Zhang, Haoke Zhang, Zheng Zhao, Junwei Wang, Laurent Maron, Lijie Liu   +10 more
wiley   +1 more source

Salicylic acid attenuates brassinosteroid signaling via protein de-S-acylation. [PDF]

EMBO J, 2023
Liu X, Chen Z, Huang L, Ouyang Y, Wang Z, Wu S, Ye W, Yu B, Zhang Y, Yang C, Lai J.   +10 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source