Results 161 to 170 of about 21,334,376 (275)

Carbon and Heteroatom Activation via N‐Heterocyclic Carbene‐Bound Dearomative Intermediates for Stereoselective Annulation Reactions

Chemistry – A European Journal, EarlyView.
Use of N‐heterocyclic carbenes (NHCs) to activate carbon and heteroatoms in aromatic compounds is reviewed based on key dearomative NHC‐bound intermediates, i.e., ortho‐quinodimethanes (o‐QDMs), ortho‐quinone methides (o‐QMs) and aza‐analogs (aza‐o‐QMs), aza‐fulvene and triaza‐diene intermediates.
Carmela De Risi, Graziano Di Carmine, Daniele Ragno, Lorenzo Poletti, Alessandro Massi   +4 more
wiley   +1 more source

Synthesis of Cyclobutane‐Containing Tricyclic β‐Lactams Based on a Saturated Scaffold Enabled by Iron‐catalysed [2 + 2]‐Cycloaddition

Chemistry – A European Journal, EarlyView.
First syntheses of pyrrolidine‐, piperidine‐, and azepane tricyclic β‐lactams based on a saturated scaffold are achieved through an Fe‐pyrimidinediimine‐catalysed [2 + 2] cycloaddition of allylamines analogues followed by photo‐induced intramolecular C─H insertion.
Lea Freitag, Johannes Zeh, Levi A. Ziegenhagen, Felix J. Becker, Dragoș‐Adrian Roșca   +4 more
wiley   +1 more source

New protein fluorescent labeling methods for carbonylation and S-acylation studies in plants [PDF]

BIO Web of Conferences
Román Andrea, Priego Salvador, Castro Antonio J., Alche Juan De Dios   +3 more
doaj   +1 more source

Tuning the Excited State Character of Amine/Carbonyl Thermally Activated Delayed Fluorescence Emitters with Ring Fusion

Chemistry – A European Journal, EarlyView.
Ring fusion in MR‐TADF emitters can affect the charge transfer excited state and therefore the photophysical properties. Here we investigate the effect of ring fusion in two structurally similar molecules to identify the advantages and disadvantages of this strategy.
Thomas Kalab, Athan T. Gogoulis, Brian O. Patrick, Zachary M. Hudson   +3 more
wiley   +1 more source

Determination of Diketopiperazine Formation During the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

Chemistry–Methods, EarlyView.
Diketopiperazine formation (DKP) is one of the most serious side reactions during peptide synthesis. An accurate method to determine the DKP formation in peptide synthesis on Wang resin is reported. Furthermore, the strategies to minimize this side reaction and side products lacking C‐terminal amino acids are described. Diketopiperazine formation (DKP)
Mani Kaushal, Ashish Kumar, Hassan Gamal, Sinenhlanhla N. Mthembu, Rotimi Sheyi, XiaoKang Kou, Beatriz G. de la Torre, Fernando Albericio   +7 more
wiley   +1 more source

4‐Methylbenzhydryl Bromine Resin: Bridging the Gap between 2‐Chlorotrityl Chloride and Wang‐Type Resins for the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

Chemistry–Methods, EarlyView.
Methylbenzhydryl bromine resin give good performance in specific condition copared to wang and 2‐chlorotrityl chloride resin. Over the last year, peptides have been consolidated as an important class of biomolecules, receiving increased attention from the pharmaceutical, cosmetic, and food industries. Most peptides currently used in both industrial and
Hassan Gamal, Mani Kaushal, Ashish Kumar, Sikabwe Noki, Cheng Zhang, Chaoyang Wang, Xiaokang Kou, Alessandra Basso, Simona Serban, Beatriz G. de la Torre, Fernando Albericio   +10 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

A Radical‐Based, Transition Metal‐Free Approach for Diaryl Ketone Synthesis

ChemSusChem, EarlyView.
A sustainable and scalable one‐pot route to diverse diaryl ketones is described, proceeding via a distinctive radical process between aryl halides and benzonitriles, initiated by KOtBu/DMA and driven by air as the sole oxidant. Free from transition metals, peroxides, and carbon monoxide, this catalyst‐free and selective method exhibits broad functional
Dongjie Wang, Jordan Garo, Yinpeng Wang, Jean‐Marc Sotiropoulos, Marc Taillefer   +4 more
wiley   +1 more source

Discovery of Some New Heterocyclic Systems from Carbene‐Based Reactions of Indigo and N‐Methyl Derivatives

European Journal of Organic Chemistry, EarlyView.
Accessing new heterocyclic structural space on exposure of indigo‐based substrates to carbene or carbenoid reactive intermediates is the key focus of this work. A number of unprecedented heterocyclic products have been discovered and their structures characterized.
Sarfaraz Ali Ghumro, Matthew J. Perry, Christopher Richardson, Stephen G. Pyne, John B. Bremner, Paul A. Keller   +5 more
wiley   +1 more source

S-acylation-dependent membrane microdomain localization of the regulatory Kvβ2.1 subunit. [PDF]

Cell Mol Life Sci, 2022
Roig SR, Cassinelli S, Navarro-Pérez M, Pérez-Verdaguer M, Estadella I, Capera J, Felipe A.   +6 more
europepmc   +1 more source