Palmitoylation: A Fatty Regulator of Myocardial Electrophysiology
Frontiers in Physiology, 2020 Regulation of cardiac physiology is well known to occur through the action of kinases that reversibly phosphorylate ion channels, calcium handling machinery, and signaling effectors.
Kobina Essandoh +5 more
doaj +1 more source
Juxta-membrane S-acylation of plant receptor-like kinases is likely fortuitous and does not necessarily impact upon function [PDF]
, 2019 This work was funded by UK Biotechnology and Biological Sciences Research Council Grants BB/M024911/1 and BB/M010996/1 to P.A.H.S-acylation is a common post-translational modification of membrane protein cysteine residues with many regulatory roles.
Hemsley, Piers +5 more
core +4 more sources
An outlook on protein S-acylation in plants:what are the next steps? [PDF]
, 2017 S-acylation, also known as palmitoylation, is the reversible post-translational addition of fatty acids to proteins. Historically thought primarily to be a means for anchoring otherwise soluble proteins to membranes, evidence now suggests that reversible
Hemsley, Piers A.
core +2 more sources
S-Acyl Glutathione Thioesterase of Plant Tissue [PDF]
Plant Physiology, 1974 The enzymic hydrolysis of S-acyl glutathione has been observed in extracts of various plant tissues. The richest source found in this study was avocado mesocarp. No enzymic activity was observed with acetyl coenzyme A or acetylthiocholine as substrates. Hydrolytic activity was essentially constant in the pH range 7 to 9.
L K, Winberry, J B, Mudd
openaire +2 more sources
Substrate selectivity in the zDHHC family of S-acyltransferases [PDF]
, 2017 S-acylation is a reversible lipid modification occurring on cysteine residues mediated by a family of membrane-bound 'zDHHC' enzymes. S-acylation predominantly results in anchoring of soluble proteins to membrane compartments or in the trafficking of ...
Chamberlain, Luke H. +5 more
core +1 more source
Distinct Roles of N-Terminal Fatty Acid Acylation of the Salinity-Sensor Protein SOS3
Frontiers in Plant Science, 2021 The Salt-Overly-Sensitive (SOS) pathway controls the net uptake of sodium by roots and the xylematic transfer to shoots in vascular plants. SOS3/CBL4 is a core component of the SOS pathway that senses calcium signaling of salinity stress to activate and ...
Irene Villalta +10 more
doaj +1 more source
S-acylation of the insulin-responsive aminopeptidase (IRAP) : quantitative analysis and identification of modified cysteines [PDF]
, 2015 The insulin-responsive aminopeptidase (IRAP) was recently identified as an S-acylated protein in adipocytes and other tissues. However, there is currently no information on the extent of S-acylation of this protein, the residues that are modified, or the
Chamberlain, Luke H., Werno, Martin W.
core +1 more source
The role of S‐acylation in protein trafficking [PDF]
Traffic, 2017 Protein S‐acylation, also known as palmitoylation, consists of the addition of a lipid molecule to one or more cysteine residues through a thioester bond. This modification, which is widespread in eukaryotes, is thought to affect over 12% of the human proteome.
José L. Daniotti +2 more
openaire +3 more sources
Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane [PDF]
, 2019 Rif1 is involved in telomere homeostasis, DNA replication timing, and DNA double-strand break (DSB) repair pathway choice from yeast to human. The molecular mechanisms that enable Rif1 to fulfill its diverse roles remain to be determined.
A Davé +69 more
core +1 more source
Differential S-acylation of Enveloped Viruses
Protein & Peptide Letters, 2019 Post-translational modifications often regulate protein functioning. Covalent attachment of long chain fatty acids to cysteine residues via a thioester linkage (known as protein palmitoylation or S-acylation) affects protein trafficking, protein-protein and protein-membrane interactions.
Larisa V, Kordyukova +3 more
openaire +2 more sources