Results 51 to 60 of about 36,153 (123)

A novel pathway for lipid biosynthesis: the direct acylation of glycerol

Journal of Lipid Research, 2001
The acylation of glycerol-3-phosphate by acyl-CoA is regarded as the first committed step for the synthesis of the lipoidal moiety in glycerolipids. The direct acylation of glycerol in mammalian tissues has not been demonstrated.
Douglas P. Lee, Andrew S. Deonarine, Martin Kienetz, Quansheng Zhu, Monika Skrzypczak, Monroe Chan, Patrick C. Choy   +6 more
doaj   +1 more source

Lipoprotein N-Acylation in Staphylococcus aureus Is Catalyzed by a Two-Component Acyl Transferase System

mBio, 2020
Bacterial lipoproteins (Lpps) are a class of membrane-associated proteins universally distributed among all bacteria. A characteristic N-terminal cysteine residue that is variably acylated anchors C-terminal globular domains to the extracellular surface,
John H. Gardiner, Gloria Komazin, Miki Matsuo, Kaitlin Cole, Friedrich Götz, Timothy C. Meredith   +5 more
doaj   +1 more source

Palmitoylation: a protein S-acylation with implications for breast cancer [PDF]

npj Breast Cancer, 2016
AbstractProtein S-acylation is a reversible post-translational lipid modification that involves linkage of a fatty acid chain predominantly to a cysteine amino acid via a thioester bond. The fatty acid molecule is primarily palmitate, thus the term ‘palmitoylation’ is more commonly used.
Anderson, Alison M., Ragan, Mark A.
openaire   +3 more sources

Palmitoylation of the envelope membrane proteins GP5 and M of porcine reproductive and respiratory syndrome virus is essential for virus growth.

PLoS Pathogens, 2021
Porcine reproductive and respiratory syndrome virus (PRRSV), an enveloped positive-strand RNA virus in the Arteiviridae family, is a major pathogen affecting pigs worldwide. The membrane (glyco)proteins GP5 and M form a disulfide-linked dimer, which is a
Minze Zhang, Xiaoliang Han, Klaus Osterrieder, Michael Veit   +3 more
doaj   +1 more source

Technologies and Challenges in Proteomic Analysis of Protein S-acylation [PDF]

Journal of Proteomics & Bioinformatics, 2014
Protein S-acylation (also called palmitoylation) is a pervasive post-translational modification that plays critical roles in regulating protein trafficking, localization, stability, activity, and complex formation. The past decade has witnessed tremendous advances in the study of protein S-acylation, largely owing to the development of novel S ...
Zhou, Bo, An, Mingrui, Freeman, Michael R, Yang, Wei   +3 more
openaire   +2 more sources

Putative DHHC-cysteine-rich domain S-acyltransferase in plants. [PDF]

PLoS ONE, 2013
Protein S-acyltransferases (PATs) containing Asp-His-His-Cys within a Cys-rich domain (DHHC-CRD) are polytopic transmembrane proteins that are found in eukaryotic cells and mediate the S-acylation of target proteins. S-acylation is an important secondary
Xiaowei Yuan, Shizhong Zhang, Meihong Sun, Shiyang Liu, Baoxiu Qi, Xinzheng Li   +5 more
doaj   +1 more source

Guanidine N-methylation by BlsL Is Dependent on Acylation of Beta-amine Arginine in the Biosynthesis of Blasticidin S

Frontiers in Microbiology, 2017
The peptidyl nucleoside blasticidin S (BS) produced by Streptomyces griseochromogenes was the first non-mercurial fungicide used to prevent rice blast and increasingly used as a selection reagent in transgenic study.
Xiankun Wang, Aiqin Du, Guiyang Yu, Zixin Deng, Xinyi He   +4 more
doaj   +1 more source

Fatty acid acylation of proteins: specific roles for palmitic, myristic and caprylic acids

Oilseeds and fats, crops and lipids, 2016
Fatty acid acylation of proteins corresponds to the co- or post-translational covalent linkage of an acyl-CoA, derived from a fatty acid, to an amino-acid residue of the substrate protein.
Rioux Vincent
doaj   +1 more source

Proteomic analysis of a poplar cell suspension culture suggests a major role of protein S-acylation in diverse cellular processes

Frontiers in Plant Science, 2016
S-acylation is a reversible post-translational modification (PTM) of proteins known to be involved in membrane targeting, subcellular trafficking and the determination of a great variety of functional properties of proteins.
Vaibhav eSrivastava, Joseph R. Weber, Erik eMalm, Bruce William Fouke, Vincent eBulone, Vincent eBulone   +5 more
doaj   +1 more source

Bioinformatics and Expression Profiling of the DHHC-CRD S-Acyltransferases Reveal Their Roles in Growth and Stress Response in Woodland Strawberry (Fragaria vesca)

Plants
Protein S-acyl transferases (PATs) are a family of enzymes that catalyze protein S-acylation, a post-translational lipid modification involved in protein membrane targeting, trafficking, stability, and protein–protein interaction.
Si Gu, Xinghua Nie, Amal George, Kyle Tyler, Yu Xing, Ling Qin, Baoxiu Qi   +6 more
doaj   +1 more source