Results 61 to 70 of about 21,334,376 (275)

S-Acylation Regulates the Membrane Association and Activity of Calpain-5

bioRxiv, 2022
Calpain-5 (CAPN5) is a member of the calpain family of calcium-activated neutral thiol proteases. CAPN5 is partly membrane associated, despite its lack of a transmembrane domain. Unlike classical calpains, CAPN5 contains a C-terminal C2 domain.
J. Gal, Vimala Bondada, Charles B. Mashburn, D. Rodgers, D. E. Croall, J. Geddes   +5 more
semanticscholar   +1 more source

Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles

Journal of Extracellular Vesicles, 2020
Extracellular vesicles (EVs) are membrane-enclosed particles that play an important role in cancer progression and have emerged as a promising source of circulating biomarkers. Protein S-acylation, frequently called palmitoylation, has been proposed as a
Javier Mariscal, Tatyana Vagner, Minhyung Kim, Bo Zhou, Andrew Chin, Mandana Zandian, Michael R. Freeman, Sungyong You, Andries Zijlstra, Wei Yang, Dolores Di Vizio   +10 more
doaj   +1 more source

Versatility of Acyl-Acyl Carrier Protein Synthetases

Chemistry & Biology, 2014
The acyl carrier protein (ACP) requires posttranslational modification with a 4'-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E ...
Kara Finzel, Joris Beld, Michael D. Burkart   +2 more
openaire   +3 more sources

S-Acylation of Proteins of Coronavirus and Influenza Virus: Conservation of Acylation Sites in Animal Viruses and DHHC Acyltransferases in Their Animal Reservoirs

Pathogens, 2021
Recent pandemics of zoonotic origin were caused by members of coronavirus (CoV) and influenza A (Flu A) viruses. Their glycoproteins (S in CoV, HA in Flu A) and ion channels (E in CoV, M2 in Flu A) are S-acylated.
Dina A Abdulrahman, Xiao-rong Meng, M. Veit   +2 more
semanticscholar   +1 more source

Dynamic acylome reveals metabolite driven modifications in Syntrophomonas wolfei

Frontiers in Microbiology, 2022
Syntrophomonas wolfei is an anaerobic syntrophic microbe that degrades short-chain fatty acids to acetate, hydrogen, and/or formate. This thermodynamically unfavorable process proceeds through a series of reactive acyl-Coenzyme A species (RACS). In other
Janine Y. Fu, John M. Muroski, Mark A. Arbing, Jessica A. Salguero, Neil Q. Wofford, Michael J. McInerney, Robert P. Gunsalus, Robert P. Gunsalus, Robert P. Gunsalus, Joseph A. Loo, Joseph A. Loo, Joseph A. Loo, Joseph A. Loo, Rachel R. Ogorzalek Loo, Rachel R. Ogorzalek Loo, Rachel R. Ogorzalek Loo   +15 more
doaj   +1 more source

A broad inhibitor of acyl-acyl carrier protein synthetases

Biochemistry and Biophysics Reports, 2023
The acyl-acyl carrier protein synthetase enzyme enables some bacteria to scavenge free fatty acids from the environment for direct use in lipids. This fatty acid recycling pathway can help pathogens circumvent fatty acid synthase (FAS) inhibition with established antibiotics and those in clinical development.
Magdalena Todorinova, Joris Beld, Kara L. Jaremko   +2 more
openaire   +3 more sources

Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

Cell Reports, 2021
Summary: In addition to acetylation, histones are modified by a series of competing longer-chain acylations. Most of these acylation marks are enriched and co-exist with acetylation on active gene regulatory elements.
Mengqing Gao, Jin Wang, Sophie Rousseaux, Minjia Tan, Lulu Pan, Lijun Peng, Sisi Wang, Wenqian Xu, Jiayi Ren, Yuanfang Liu, Martin Spinck, Sophie Barral, Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Denis Puthier, Sandrine Curtet, Lisa Bargier, Zhongyi Cheng, Heinz Neumann, Jian Li, Yingming Zhao, Jian-Qing Mi, Saadi Khochbin   +23 more
doaj   +1 more source

An ABHD17-like hydrolase screening system to identify de-S-acylation enzymes of protein substrates in plant cells.

The Plant Cell, 2021
Protein S-acylation is an important post-translational modification in eukaryotes, regulating the subcellular localization, trafficking, stability, and activity of substrate proteins.
Xiaoshi Liu, Min Li, Yang Li, Zian Chen, Chun-chun Zhuge, Youwei Ouyang, Yawen Zhao, Yuxin Lin, Qi Xie, Chengwei Yang, Jianbin Lai   +10 more
semanticscholar   +1 more source

Acylated and non-acylated anthocyanins as antibacterial and antibiofilm agents

Discover Food, 2023
AbstractNatural products have served as an essential source of medicinal compounds in drug discovery, with their high abundance in nature and structural complexity being beneficial for various biological activities. Anthocyanins are a natural food colourant that belongs to the flavonoid group of compounds responsible for the colour of various fruits ...
Jeyaraj, Ethel Jeyaseela, Vidana Gamage, Gayan Chandrajith, Cintrat, Jean-Christophe, Choo, Wee Sim   +3 more
openaire   +4 more sources

Synthesis and Characterization of 2-Decenoic Acid Modified Chitosan for Infection Prevention and Tissue Engineering

Marine Drugs, 2021
Chitosan nanofiber membranes are recognized as functional antimicrobial materials, as they can effectively provide a barrier that guides tissue growth and supports healing. Methods to stabilize nanofibers in aqueous solutions include acylation with fatty
Carlos Montez Wells, Emily Carol Coleman, Rabeta Yeasmin, Zoe Lynn Harrison, Mallesh Kurakula, Daniel L. Baker, Joel David Bumgardner, Tomoko Fujiwara, Jessica Amber Jennings   +8 more
doaj   +1 more source