Noncanonical Amino Acids in the Interrogation of Cellular Protein Synthesis [PDF]
, 2011 Proteins in living cells can be made receptive to bioorthogonal chemistries through metabolic labeling with appropriately designed noncanonical amino acids (ncAAs).
Ngo, John T., Tirrell, David A.
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Quantitative analysis of protein lipidation and acyl-CoAs reveals substrate preferences of the S-acylation machinery. [PDF]
Chem SciBusquets-Hernández C +7 more
europepmc +3 more sources
S-Acylation of the cellulose synthase complex is essential for its plasma membrane localization. [PDF]
, 2016 Plant cellulose microfibrils are synthesized by a process that propels the cellulose synthase complex (CSC) through the plane of the plasma membrane. How interactions between membranes and the CSC are regulated is currently unknown.
Atanassov, Ivan +6 more
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Maize tricin-oligolignol metabolites and their implications for monocot lignification [PDF]
, 2016 Lignin is an abundant aromatic plant cell wall polymer consisting of phenylpropanoid units in which the aromatic rings display various degrees of methoxylation.
Boerjan, Wout +8 more
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Acylation – A New Means to Control Traffic Through the Golgi
Frontiers in Cell and Developmental Biology, 2019 The Golgi is well known to act as center for modification and sorting of proteins for secretion and delivery to other organelles. A key sorting step occurs at the trans-Golgi network and is mediated by protein adapters. However, recent data indicate that
Andreas M. Ernst +3 more
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Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse [PDF]
, 2018 Protein S-acylation is a widespread post-translational modification that regulates the trafficking and function of a diverse array of proteins. This modification is catalysed by a family of twenty-three zDHHC enzymes that exhibit both specific and ...
Brett, Ros R. +6 more
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S-acylation of the Wnt receptor Frizzled-5 by zDHHC5 controls its cellular localization and synaptogenic activity in the rodent hippocampus [PDF]
, 2023 Proper localization of receptors for synaptic organizing factors is crucial for synapse formation. Wnt proteins promote synapse assembly through Frizzled (Fz) receptors. In hippocampal neurons, the surface and synaptic localization of Fz5 is regulated by
Bossio, Alessandro +6 more
core
Transition-metal-free trifluoromethylthiolation–acylation of arynes by insertion into the C–S bonds
Green Synthesis and Catalysis, 2021 An efficient procedure to access to ortho-SCF3 substituted benzophenones from arynes and trifluoromethylthioesters has been developed under transition-metal free conditions. This difunctionalization process involves the first insertion of arynes into the
Chengyao Kimmy Cao +2 more
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Attenuating ABHD17 isoforms augments the S -acylation and function of NOD2 and a subset of Crohn’s disease-associated NOD2 variants [PDF]
, 2023 Charneal L. Dixon +4 more
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A novel pathway for lipid biosynthesis: the direct acylation of glycerol
Journal of Lipid Research, 2001 The acylation of glycerol-3-phosphate by acyl-CoA is regarded as the first committed step for the synthesis of the lipoidal moiety in glycerolipids. The direct acylation of glycerol in mammalian tissues has not been demonstrated.
Douglas P. Lee +6 more
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