Results 61 to 70 of about 36,153 (123)

Going Round in Circles with N→S Acyl Transfer [PDF]

Synlett, 2017
It is not highly sophisticated, yet the N→S acyl transfer reaction of a native peptide sequence potentially fills an important technology gap. While several routes to synthetic peptide thioesters exist, only one is routinely applicable for biologically derived samples. Using the naturally occurring amino acid cysteine as the sole activator for N→S acyl
openaire   +2 more sources

Protocol to identify S-acylated proteins in hippocampal neurons using ω-alkynyl fatty acid analogs and click chemistry

STAR Protocols
Summary: S-acylation, commonly palmitoylation, is the addition of fatty acids to cysteines to regulate protein localization and function. S-acylation detection has been hampered by limited sensitivity and selectivity in low-protein, costly samples like ...
Charlotte A. Townsend, Andrey A. Petropavlovskiy, Jordan A. Kogut, Alysha M. Church, Shaun S. Sanders   +4 more
doaj   +1 more source

Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking

JCI Insight, 2021
The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is not well understood. Here, we investigated how the LCFA transporter CD36 regulates this process.
Alexes C. Daquinag, Zhanguo Gao, Cale Fussell, Linnet Immaraj, Renata Pasqualini, Wadih Arap, Askar M. Akimzhanov, Maria Febbraio, Mikhail G. Kolonin   +8 more
doaj   +1 more source

Protein acylation in inflammatory diseases: from mechanisms to therapeutic strategies

Cell Communication and Signaling
Protein acylation, a critical subset of post-translational modifications (PTMs), serves as a dynamic regulatory mechanism linking cellular metabolism, epigenetic regulation, and inflammatory responses.
Jiayi Ding, Huiyi Wang, Zhengkun Yang, Xiaoxuan Wang, Zhengguo Cao   +4 more
doaj   +1 more source

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitros⃞

Journal of Lipid Research, 2009
Pharmacologic approaches to studying palmitoylation are limited by the lack of specific inhibitors. Recently, screens have revealed five chemical classes of small molecules that inhibit cellular processes associated with palmitoylation (Ducker, C. E., L.
Benjamin C. Jennings, Marissa J. Nadolski, Yiping Ling, Meredith Beckham Baker, Marietta L. Harrison, Robert J. Deschenes, Maurine E. Linder   +6 more
doaj   +1 more source

Grain setting defect1 (GSD1) function in rice depends on S-acylation and interacts with actin 1 (OsACT1) at its C-terminal

Frontiers in Plant Science, 2015
Grain setting defect1 (GSD1), a plant-specific remorin protein specifically localized at the plasma membrane and plasmodesmata of phloem companion cells, affects grain setting in rice through regulating the transport of photoassimilates.
Jinshan eGui, Shuai eZheng, Junhui eShen, Laigeng eLi   +3 more
doaj   +1 more source

Radiosynthesis, structural identification and in vitro tissue binding study of [18F]FNA-S-ACooP, a novel radiopeptide for targeted PET imaging of fatty acid binding protein 3

EJNMMI Radiopharmacy and Chemistry
Background Fatty acid binding protein 3 (FABP3) is a target with clinical relevance and the peptide ligand ACooP has been identified for FABP3 targeting.
Pyry Dillemuth, Tuomas Karskela, Abiodun Ayo, Jesse Ponkamo, Jonne Kunnas, Johan Rajander, Olli Tynninen, Anne Roivainen, Pirjo Laakkonen, Anu J. Airaksinen, Xiang-Guo Li   +10 more
doaj   +1 more source

Native N-glycopeptide thioester synthesis through N→S acyl transfer

Bioorganic & Medicinal Chemistry Letters, 2011
Peptide thioesters are important tools for the total synthesis of proteins using native chemical ligation (NCL). Preparation of glycopeptide thioesters, that enable the assembly of homogeneously glycosylated proteins, is complicated by the perceived fragile nature of the sugar moiety.
Premdjee, Bhavesh, Adams, Anna L., Macmillan, Derek   +2 more
openaire   +2 more sources

Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9

eLife
Mutations in the X-linked ZDHHC9 gene cause cognitive deficits in humans, with a subset of patients suffering from epilepsy. X-linked intellectual disability (XLID) is often ascribed to neuronal deficits, but here we report that expression of human and ...
Hey-Kyeong Jeong, Estibaliz Gonzalez-Fernandez, Ilan Crawley, Julia M Coakley, Jinha Hwang, Dale DO Martin, Shernaz X Bamji, Jong-Il Kim, Shin H Kang, Gareth M Thomas   +9 more
doaj   +1 more source

S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy. [PDF]

Mol Cell, 2023
Huang X, Yao J, Liu L, Chen J, Mei L, Huangfu J, Luo D, Wang X, Lin C, Chen X, Yang Y, Ouyang S, Wei F, Wang Z, Zhang S, Xiang T, Neculai D, Sun Q, Kong E, Tate EW, Yang A.   +20 more
europepmc   +1 more source