Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases [PDF]
, 2015 S-acylation is a major post-translational modification affecting several cellular processes and being particularly important for neuronal functions. This modification is catalysed by a family of transmembrane S-acyl-transferases that contain a conserved ...
Chamberlain, Luke H. +2 more
core +1 more source
Protein palmitoylation plays an important role in Trichomonas vaginalis adherence [PDF]
, 2018 The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide.
Corvi, Maria Martha +6 more
core +2 more sources
Fats and function:protein lipid modifications in plant cell signalling [PDF]
, 2017 The post-translational lipid modifications N-myristoylation, prenylation and S-acylation are traditionally associated with increasing protein membrane affinity.
Adjobo-Hermans +54 more
core +2 more sources
Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry [PDF]
, 2017 S-Acylation is a major post-translational modification, catalysed by the zDHHC enzyme family. S-acylated proteins can be modified by different fatty acids; however, very little is known about how zDHHC enzymes contribute to acyl chain heterogeneity. Here,
Chamberlain, Luke H. +7 more
core +1 more source
Potato mop-top virus co-opts the stress sensor HIPP26 for long-distance movement [PDF]
, 2018 The work of LT, GC, SJ and AR is funded by the Scottish Government’s Rural and Environmental Science and Analytical Services (RESAS) Division, PH by the BBSRC (grant BB/M024911/1) and The Royal Society and EIS by the Swedish Research Council Formas and ...
Cowan, Graham H. +8 more
core +4 more sources
S-acylation of Orai1 regulates store-operated Ca2+ entry. [PDF]
J Cell Sci, 2022 ABSTRACT Store-operated Ca2+ entry is a central component of intracellular Ca2+ signaling pathways. The Ca2+ release-activated channel (CRAC) mediates store-operated Ca2+ entry in many different cell types. The CRAC channel is composed of the plasma membrane (PM)-localized Orai1 channel and endoplasmic reticulum (ER)-localized STIM1 Ca2+
West SJ +6 more
europepmc +3 more sources
Detection of Heterogeneous Protein S-Acylation in Cells [PDF]
, 2019 The use of synthetically synthesized azide and alkyne fatty acid analogs coupled with bioorthogonal Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction-based detection methods to study protein S-acylation reactions has replaced the traditional method of using in vivo metabolic radiolabeling with tritiated palmitic acid and has greatly ...
Greaves, Jennifer +1 more
openaire +3 more sources
Frontiers in Physiology, 2014 Mechanisms that control surface expression and/or activity of large conductance calcium-activated potassium (BK) channels are important determinants of their (patho)physiological function.
Michael J Shipston
doaj +1 more source
2-Bromopalmitate reduces protein deacylation by inhibition of acyl-protein thioesterase enzymatic activities. [PDF]
PLoS ONE, 2013 S-acylation, the covalent attachment of palmitate and other fatty acids on cysteine residues, is a reversible post-translational modification that exerts diverse effects on protein functions.
Maria P Pedro +5 more
doaj +1 more source
New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness [PDF]
, 2017 Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide ...
EDWARD W. TATE +4 more
core +1 more source