Thermodynamic parameters for the binding of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) to WspC-Pp and its shortened versions WspC-Ppmiddle (WspC-Pp lacking TPR domain) and WspC-Ppshort (WspC-Pp lacking TPR domain and linker). [PDF]
, 2012 Thermodynamic parameters for the binding of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) to WspC-Pp and its shortened versions WspC-Ppmiddle (WspC-Pp lacking TPR domain) and WspC-Ppshort (WspC-Pp lacking TPR domain and linker).
Cristina García-Fontana (133781) +4 more
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Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
Viruses, 2010 The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the ...
Erik De Clercq
doaj +1 more source
Evidence for disturbed S-adenosylmethionine: S-adenosylhomocysteine ratio in patients with end-stage renal failure: a cause for disturbed methylation reactions? [PDF]
, 2017 BACKGROUND: Elevated homocysteine concentrations have been associated with premature arteriosclerosis and with impairment of key methylation reactions through accumulation of the homocysteine metabolite S-adenosylhomocysteine.
Angst, C P. +4 more
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‐Adenosylhomocysteine hydrolase deficiency in a 26‐year‐old man [PDF]
, 2006 This paper reports the third proven human case of deficient S-adenosylhomocysteine (AdoHcy) hydrolase activity. The patient is similar to the only two previously reported cases with this disorder in having severe myopathy, developmental delay, elevated ...
Vugrek, O. +21 more
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Design, Synthesis, and Biological Activity of 6′-β-Fluoroaristeromycin Analogues as Potent S-Adenosylhomocysteine Hydrolase Inhibitor [PDF]
, 2014 The antiviral activities of carbocyclic adenosine analogues are well known and they have been shown to be due, or at least in part, to the inhibition of S-adenosylhomocysteine (SAH) hydrolase.
김상아
core
Methylthioadenosine/S-adenosylhomocysteine Nucleosidase, a Critical Enzyme for Bacterial Metabolism [PDF]
, 2010 The importance of methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in bacteria has started to be appreciated only in the past decade. A comprehensive analysis of its various roles here demonstrates that it is an integral component of the
Parveen, Nikhat +3 more
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Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries
Biochemistry Research International, 2012 Alcohol is readily distributed throughout the body in the blood stream and crosses biological membranes, which affect virtually all biological processes inside the cell.
Cheng Ji
doaj +1 more source
STEREOCHEMICAL AND MECHANISTIC INVESTIGATIONS OF S-ADENOSYLHOMOCYSTEINE HYDROLASE (ACETYLENIC ADENOSINE) [PDF]
, 1986 S-Adenosylhomocysteine Hydrolase (SAHase) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (SAH) to adenosine and homocysteine in an addition-elimination mechanism. This mechanism could follow one of four possible stereochemical pathways. To
ASKONAS, LESLIE JEAN
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Design, Synthesis, and Biological Evaluation of Fluoroneplanocin A as the Novel Mechanism-Based Inhibitor of S-Adenosylhomocysteine Hydrolase [PDF]
, 2016 Fluoroneplanocin A (12) was designed as a novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase (SAH) and efficiently synthesized via an electrophilic vinyl fluorination reaction (n-BuLi, N-fluorobenzenesulfonimide at −78 °C ...
Su Jeong Yoo (3016227) +10 more
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Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase [PDF]
, 2018 Fluoroneplanocin A (12) was designed as a novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase (SAH) and efficiently synthesized via an electrophilic vinyl fluorination reaction (n-BuLi, N-fluorobenzenesulfonimide at -78 °C ...
이상국, 이강만, 정낙신
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