Results 91 to 100 of about 15,817,770 (195)

Stereoselective Synthesis of a Novel Apio Analogue of Neplanocin A as Potential S-Adenosylhomocysteine Hydrolase Inhibitor [PDF]

, 2016
A total synthesis of apio-neplanocin A, which combines properties of apio nucleoside and neplanocin A and is a potential inhibitor of S-adenosylhomocysteine hydrolase, was accomplished starting from d-ribose via stereoselective hydroxymethylation and RCM
Lak Shin Jeong (1309611), Moon Woo Chun (2655106), Kang Man Lee (2228881), Hea Ok Kim (1309608), Hyung Ryong Moon (310525), Joong Hyup Kim (3066009)   +5 more
core   +1 more source

Multi‐Omics Profiling of the Scaphoideus titanus Yeast‐Like Symbiont Guides the Bioinformatic Discovery of Related Fungal Symbioses in Insects

Environmental Microbiology, Volume 28, Issue 7, July 2026.
Genomic, proteomic and phylogenetic analyses of the obligate yeast‐like symbiont (YLS) associated with Scaphoideus titanus revealed retained metabolic flexibility and a monophyletic origin of insect‐associated YLSs within a free‐living fungal lineage. A novel computational pipeline was used to mine NCBI transcriptomic data and identified new candidate ...
Simona Abbà, Marta Vallino, Alessandro Cicerone, Simona Cirrincione, Beatrice Aiuto, Luciana Galetto, Marika Rossi   +6 more
wiley   +1 more source

Neplanocin A 유도체의 S-Adenosylhomocysteine hydrolase에 대한 저해 효과와 그 작용 기전에 관한 연구 [PDF]

, 2002
S-adenosylhomocysteine hydrolase는 adenosylhomocysteine을 adenosine과 homocysteine으로 가수분해시키는 효소이다. 이 효소는 대부분의 바이러스가 복제하는데 있어서 공통적으로 필요로 하는 효소로서, viral mRNA의 전사에 필수적인 viral mRNA의 5´-terminal capped methylated structure의 형성에 관여한다.
구미정
core  

Skeletal muscle‐specific myostatin overexpression promotes muscle oxidative capacity and fatigue resistance in transgenic mice

Experimental Physiology, Volume 111, Issue 7, Page 3357-3380, 1 July 2026.
Abstract In addition to controlling muscle mass, myostatin may support oxidative metabolism and endurance. Loss of function through gene knockout or post‐natal blockade generally lowers muscle oxidative capacity and increases fatigability. These observations imply that myostatin activation could promote a more oxidative and less fatigable muscle ...
Andy V. Khamoui, Andrea Abraham, Janos Porszasz, Istvan Kovanecz, Silvana Constantinescu, Harry B. Rossiter, Suzanne Reisz‐Porszasz   +6 more
wiley   +1 more source

Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Enzyme assays and computational analyses reveal that human histidine methyltransferases SETD3 and METTL9 have a capacity to catalyze histidine ethylation in the presence of synthetic or in situ produced S‐adenosylethionine (AdoEth) and Se‐adenosylselenoethionine (AdoSeEth) cosubstrates.
Jordi C. J. Hintzen, Zhimei Yu, Sadaf Ahmad, Xin Zhang, Yuan–Yuan Zhao, Hao Deng, Leonie Schütz, Marija Ram, Julia Z. Kaminska, Jakub Drozak, Elmar Weinhold, Hong Guo, Andrea Rentmeister, Ping Qian, Jasmin Mecinović   +14 more
wiley   +1 more source

Nuclear accumulation of S-adenosylhomocysteine hydrolase in transcriptionally active cells during development of Xenopus laevis [PDF]

, 1999
The oocyte nuclear antigen of the monoclonal antibody 32-5B6 of Xenopus laevis is subject to regulated nuclear translocation during embryogenesis. It is distributed in the cytoplasm during oocyte maturation, where it remains during cleavage and blastula ...
Kaufmann, C., Dreyer, C., Radomski, N.
core   +1 more source

Oxidation Products of S‐Adenosyl Methionine Probed by Infrared Multiple Photon Dissociation Spectroscopy

ChemPhysChem, Volume 27, Issue 12, 26 June 2026.
HO•‐induced oxidation is structurally resolved in S‐adenosyl methionine (SAM). Infrared multiple photon dissociation (IRMPD) spectroscopy and density functional theory (DFT) calculations reveal clear spectroscopic signatures of adenine C8 oxidation. S‐adenosyl methionine (SAM) is a key biomolecule in cellular processes, acting as a primary methyl donor,
Jean‐Xavier Bardaud, Yining Jiang, Carine Clavaguera, Chantal Houée‐Levin, Giel Berden, Jos Oomens, Debora Scuderi   +6 more
wiley   +1 more source

Colorimetric Assay for S-Adenosylhomocysteine Hydrolase Activity and Inhibition Using Fluorosurfactant-Capped Gold Nanoparticles [PDF]

, 2016
This study reports a simple colorimetric method for the sensitive detection of S-adenosylhomocysteine hydrolase (SAHH) activity and inhibition using fluorosurfactant-capped gold nanoparticles (FSN-AuNPs).
Chung-Wei Chang (2255830), Zong-Han Wu (1431400), Jia-Hui Lin (2255833), Wei-Lung Tseng (1499176)   +3 more
core   +1 more source

Mutagenic Survey of Key Residues of NifB Involved in Radical SAM‐Dependent Nitrogenase Cofactor Assembly

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
NifB uses an RS–K1–K2 triad to assemble the L‐cluster, a [Fe8S9C] precursor of the nitrogenase cofactor. The RS module cleaves SAM to form the 5′‐dA radical, K1 serves structural/SAM‐sensing roles, and K2 drives radical‐dependent fusion with K1. SAM‐anchoring residues link SAM binding to cluster fusion, while termini and surface residues regulate ...
Calder Duffin, Robert Quechol, Yimo Yang, Chi Chung Lee, Yilin Hu, Markus W. Ribbe   +5 more
wiley   +1 more source

The McbR repressor modulated by the effector substance S-adenosylhomocysteine controls directly the transcription of a regulon involved in sulphur metabolism of Corynebacterium glutamicum ATCC 13032 [PDF]

, 2005
Rey DA, Nentwich SS, Koch DJ, et al. The McbR repressor modulated by the effector substance S-adenosylhomocysteine controls directly the transcription of a regulon involved in sulphur metabolism of Corynebacterium glutamicum ATCC 13032.
Nentwich, S. S., Rückert, Christian ; https://orcid.org/, Koch, D. J., Tauch, Andreas, Rey, D. A., Pühler, Alfred ; https://orcid.org/, Kalinowski, Jörn   +6 more
core   +1 more source