Results 101 to 110 of about 15,817,770 (195)

Evaluation of Nucleoside Analogs as Antimicrobials Targeting Unique Enzymes in Borrelia burgdorferi

Pathogens, 2020
The first line therapy for Lyme disease is treatment with doxycycline, amoxicillin, or cefuroxime. In endemic regions, the persistence of symptoms in many patients after completion of antibiotic treatment remains a major healthcare concern. The causative
Monideep Chakraborti, Samantha Schlachter, Shekerah Primus, Julie Wagner, Brandi Sweet, Zoey Carr, Kenneth A. Cornell, Nikhat Parveen   +7 more
doaj   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Selenium‐Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This reivew summarizes Selenium as a multifunctional anticancer regulator in gynecological cancers. It reduces tumor risk, enhances therapeutic efficacy, and reduces treatment toxicity. Selenium also overcomes chemoraditherapy resistance, improving overall treatment outcomes. ABSTRACT Gynecological cancers present significant therapeutic challenges due
Hejing Liu, Yujia Zhou, Zihan Zhang, Rong Ma, Luyi Ruan, Liqing Miao, Boxin Zhang, Huihui Ji, Tianfeng Chen, Xueqiong Zhu   +9 more
wiley   +1 more source

Asymmetric Synthesis of 6′-Fluoroaristeromycin Analogues as Potential S-Adenosylhomocysteine Hydrolase Inhibitor [PDF]

, 2012
Inhibitors of S-adenosyl-L-homocysteine (AdoHcy) hydrolase have shown promise as antiviral agents. Aristeromycin and neplanocin A are naturally occurring carbocyclic nucleosides, which act as potent inhibitors of S-adenosylhomocysteine (SAH) hydrolase ...
엄윤진
core  

Transiently elevated plasma methionine, S‐adenosylmethionine and S‐adenosylhomocysteine: Unreported laboratory findings in a patient with NGLY1 deficiency, a congenital disorder of deglycosylation

JIMD Reports, 2019
We report on a 5‐year‐old female born to consanguineous parents, ascertained at the age of 23 months for an elevated plasma methionine level, a mildly abnormal total plasma homocysteine (tHcy), and elevated aminotransferases. She had global developmental
Caitlin A. Chang, Xing‐Chang Wei, Steven R. Martin, David S. Sinasac, Walla Al‐Hertani   +4 more
doaj   +1 more source

Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Increased, homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease [PDF]

, 2003
Background: The pathogenic mechanism of homocysteine's effect on cardiovascular risk is poorly understood. Recent studies show that DNA hypomethylation induced by increases in S-adenosylhomocysteine (AdoHcy), an intermediate of Hcy metabolism and a ...
Castro, R, Rivera, I, Blom, HJ, Camilo, ME, Ravasco, P, Struys, EA, Jansen, EEW, Jakobs, C, de Almeida, IT   +8 more
core  

S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease [PDF]

, 2008
Recent epidemiological evidence showed that dietary fatty acids, antioxidants, and micronutrients appear to have a role in cognitive decline, and may permit a beneficial effect on the risk of dementia and predementia syndromes.
CAPURSO C, CAPURSO A, PANZA F, COLACICCO AM, SOLFRIZZI, Vincenzo, CAPURSO, CRISTIANO, SOLFRIZZI V., D'INTRONO A, VENDEMIALE, GIANLUIGI   +8 more
core   +1 more source

Crystallization and preliminary X-ray analysis of human placental S-adenosylhomocysteine hydrolase [PDF]

, 1997
A recombinant form of human placental S-adenosylhomocysteine (AdoHcy) hydrolase expressed in E. coli, which was inactivated by a type-I mechanism-based inhibitor, has been crystallized using the hanging-drop vapour-diffusion technique.
Turner, Mary A., M. A. Turner, R. T. Borchardt, Howell, P. Lynne, M. S. Hershfield, K. Dole, Dole, Kiran, Borchardt, Ronald T., C.-S. Yuan, P. L. Howell, Hershfield, Michael S., Yuan, Chong-Sheng   +11 more
core   +1 more source

Functional Characterization of SlSAHH2 in Tomato Fruit Ripening

Frontiers in Plant Science, 2017
S-adenosylhomocysteine hydrolase (SAHH) functions as an enzyme catalyzing the reversible hydrolysis of S-adenosylhomocysteine to homocysteine and adenosine. In the present work we have investigated its role in the ripening process of tomato fruit.
Lu Yang, Guojian Hu, Ning Li, Sidra Habib, Wei Huang, Zhengguo Li   +5 more
doaj   +1 more source