S-adenosylhomocysteine and the ratio of S-adenosylmethionine to S-adenosylhomocysteine are not related to folate, cobalamin and vitamin B6 concentrations [PDF]
European Journal of Clinical Investigation, 2003 AbstractBackground It is unclear whether homocysteine itself is causal in the pathogenesis of cardiovascular disease. Alternatively or additionally, the association between homocysteine and cardiovascular disease may be because of its metabolic precursor, S‐adenosylhomocysteine, or of the ratio of S‐adenosylmethionine to S‐adenosylhomocysteine ...
Coen Stehouwer
exaly +8 more sources
Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency. [PDF]
PLoS ONE, 2016 S-adenosylhomocysteine hydrolase (AHCY) deficiency is a rare autosomal recessive disorder in methionine metabolism caused by mutations in the AHCY gene.
Antje Motzek +10 more
doaj +4 more sources
Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy [PDF]
Stem Cell Research & Therapy, 2022 Background Autologous stem cell therapy is a promising strategy for cardiovascular diseases including diabetic cardiomyopathy (DCM), but conclusions from clinical trials were compromised.
Ying Wang +7 more
doaj +2 more sources
Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis [PDF]
Redox Biology, 2023 Aims: Vascular senescence, which is closely related to epigenetic regulation, is an early pathological condition in cardiovascular diseases including atherosclerosis.
Yiran You +11 more
doaj +2 more sources
Role of Elevated Intracellular S-Adenosylhomocysteine in the Pathogenesis of Alcohol-Related Liver Disease [PDF]
Cells, 2020 Background: The earliest manifestation of alcohol-related liver disease (ALD) is steatosis, characterized by the accumulation of lipid droplets (LDs) in hepatocytes.
Madan Kumar Arumugam +5 more
doaj +2 more sources
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity [PDF]
Biology Direct, 2023 Background Lung cancer is one of the most frequently diagnosed cancers characterized by high mortality, metastatic potential, and recurrence. Deregulated gene expression of lung cancer, likewise in many other solid tumors, accounts for their cell ...
Melina Muñoz-Bernart +13 more
doaj +2 more sources
Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community [PDF]
Scientific Reports, 2022 We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals.
Akane Mihara +13 more
doaj +2 more sources
6'-Oxa Analogs of S-Adenosylhomocysteine. [PDF]
Tetrahedron, 2012 S-Adenosylmethionine (AdoMet) is a ubiquitous cofactor in biomethylations and, in that role, becomes S-adenosylhomocysteine (AdoHcy), which serves as a biofeedback inhibitor of the methylation process. In seeking to avail unexplored structural variations of AdoHcy for biological studies, its 6'-oxa analog and two corresponding carbocyclic nucleosides ...
Li W, Ye W, Schneller SW.
europepmc +4 more sources
S-Adenosylmethionine (SAM) and S-Adenosylhomocysteine (SAH) Monitoring Using Analytical Methods in Clinical Laboratory Practice: Where Are We? [PDF]
BiomedicinesS-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are essential intermediates in one-carbon metabolism and key regulators of cellular methylation capacity. Their concentrations and the SAM/SAH ratio are increasingly studied as biomarkers across
Antonina Kuty +3 more
doaj +2 more sources
Revista Cubana de Investigaciones Biomédicas, 2006 Se realizó una revisión de la S-adenosil metionina, considerado como el donante fundamental de grupos metilo en el organismo. Por una reacción de transmetilación es obtenida la S-adenosil homocisteína, que es un potente inhibidor de transmetilasas ...
Yelamy Travieso González +3 more
doaj +1 more source