A simple rapid immunoassay for S-adenosylhomocysteine in plasma☆ [PDF]
Journal of Nutritional Biochemistry, 2007 The measurement of plasma S-adenosylhomocysteine is a more sensitive indicator of the risk for vascular disease than is plasma homocysteine. Because the level of S-adenosylhomocysteine is normally in the nanomolar range, it has been difficult to measure and necessitated the development of complex fluorometric and mass-spectrophotometric methods.
Conrad Wagner, Raymond F Burk
exaly +3 more sources
Efficacy evaluation of the S-adenosylhomocysteine hydrolase inhibitor MSD-914 in rhesus macaques (Macaca Mulatta) challenged with Ebola virus by the intramuscular route. [PDF]
PLoS ONEEbola virus (EBOV) causes a severe and often fatal hemorrhagic fever in humans for which effective postexposure countermeasures are lacking. Herein, we describe the evaluation of an S-adenosylhomocysteine hydrolase inhibitor, MSD-914, using mouse and ...
Sara C Johnston +28 more
doaj +2 more sources
Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. [PDF]
J Biol Chem, 2014 S-Adenosylhomocysteine hydrolase (SAHH) is an NAD(+)-dependent tetrameric enzyme that catalyzes the breakdown of S-adenosylhomocysteine to adenosine and homocysteine and is important in cell growth and the regulation of gene expression. Loss of SAHH function can result in global inhibition of cellular methyltransferase enzymes because of high levels of
Wang Y +5 more
europepmc +4 more sources
Metabolic perturbation of epigenome by inhibiting -adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells [PDF]
Tumor Biology, 2017 Cellular senescence is a key physiological barrier against tumor and represents an option for therapeutic intervention. One pivotal intracellular stimulus causing senescence is DNA damage response, while the senescence-associated heterochromatin in ...
Guozhen Wu +8 more
doaj +2 more sources
Correction: S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity [PDF]
Biology Direct, 2023 Melina Muñoz-Bernart +13 more
doaj +2 more sources
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase. [PDF]
Nat Commun, 2015 DNA methylation is essential for mammalian development and physiology. Here we report that the developmentally regulated H19 lncRNA binds to and inhibits S-adenosylhomocysteine hydrolase (SAHH), the only mammalian enzyme capable of hydrolysing S ...
Zhou J +13 more
europepmc +3 more sources
Redox Biology, 2021 Mitochondrial energy production and function rely on optimal concentrations of the essential redox-active lipid, coenzyme Q (CoQ). CoQ deficiency results in mitochondrial dysfunction associated with increased mitochondrial oxidative stress and a range of
Anita Ayer +19 more
doaj +1 more source
Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. [PDF]
PLoS ONE, 2016 Folate deficiency is generally accepted as a potential direct or indirect risk factor for diseases including spina bifida, coronary heart diseases, malfunctions of the central nervous system, and cancer. The direct inclusion of folates in the methylation
Markus Kopp +3 more
doaj +1 more source
Antioxidants, 2021 In the past, reactive nitrogen species (RNS) were supposed to be stress-induced by-products of disturbed metabolism that cause oxidative damage to biomolecules.
Eva Esther Rudolf +10 more
doaj +1 more source
Acute ethanol-induced liver injury is prevented by betaine administration
Frontiers in Physiology, 2022 Binge drinking is the most common form of excessive alcohol use. Repeated episodes of binge drinking cause multiple organ injuries, including liver damage.
Madan Kumar Arumugam +19 more
doaj +1 more source